mybpc3 myosin binding protein C3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mybpc3provided by ZNC
Official Full Name: myosin binding protein C3provided by ZNC
Primary source: ZFIN:ZDB-GENE-070112-2362
See related: Ensembl:ENSDARG00000011615 AllianceGenome:ZFIN:ZDB-GENE-070112-2362
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:6900815; zgc:152717; zgc:158442; hm:zehn0716
Summary: Predicted to enable myosin heavy chain binding activity. Acts upstream of or within cardiac chamber morphogenesis and regulation of heart rate. Is expressed in anterior macula; heart rudiment; musculature system; pericardial region; and trunk. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 4. Orthologous to human MYBPC3 (myosin binding protein C3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (31838263..31899208)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (31567154..31627970)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables myosin heavy chain binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cardiac atrium formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac ventricle formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in ventricular cardiac muscle tissue morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ventricular cardiac muscle tissue morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in M band	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: myosin-binding protein C, cardiac-type

Names: myosin binding protein C, cardiac

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044349.2 → NP_001037814.2 myosin-binding protein C, cardiac-type

Status: VALIDATED

Source sequence(s)

BC107633, CN179233, CO930551, DT081938, EB890884, EB892846, EB896522, EB897596, EB897718

UniProtKB/TrEMBL

A0A8M1N978

Related

ENSDARP00000109343.2, ENSDART00000122506.3

Conserved Domains (8) summary

cd00096
Location:1181 → 1245

Ig; Immunoglobulin domain

cd05748
Location:973 → 1045

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

cd05894
Location:666 → 751

Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)

smart00408
Location:478 → 536

IGc2; Immunoglobulin C-2 Type

smart00410
Location:668 → 751

IG_like; Immunoglobulin like

cd00063
Location:755 → 841

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:1164 → 1253

I-set; Immunoglobulin I-set domain

cl11960
Location:400 → 461

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

31838263..31899208

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021477538.1 → XP_021333213.1 myosin-binding protein C, cardiac-type isoform X1

UniProtKB/TrEMBL

A0A8M9Q1L9

Conserved Domains (6) summary

smart00410
Location:177 → 272

IG_like; Immunoglobulin like

cd00063
Location:792 → 878

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:1201 → 1290

I-set; Immunoglobulin I-set domain

cd05748
Location:1010 → 1082

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar domains

cl11960
Location:681 → 788

Ig; Immunoglobulin domain

cl28434
Location:578 → 642

I-set; Immunoglobulin I-set domain
XM_021477539.1 → XP_021333214.1 myosin-binding protein C, cardiac-type isoform X2

UniProtKB/TrEMBL

A0A8M9Q7V7

Conserved Domains (6) summary

smart00410
Location:177 → 272

IG_like; Immunoglobulin like

cd00063
Location:792 → 878

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:1201 → 1290

I-set; Immunoglobulin I-set domain

cd05748
Location:1010 → 1082

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar domains

cl11960
Location:681 → 788

Ig; Immunoglobulin domain

cl28434
Location:578 → 642

I-set; Immunoglobulin I-set domain
XM_021477541.1 → XP_021333216.1 myosin-binding protein C, cardiac-type isoform X5

UniProtKB/TrEMBL

A0A8M9QC07

Conserved Domains (6) summary

cd05894
Location:681 → 766

Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)

smart00410
Location:177 → 272

IG_like; Immunoglobulin like

cd00063
Location:770 → 856

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:1179 → 1268

I-set; Immunoglobulin I-set domain

cd05748
Location:988 → 1060

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar domains

cl28434
Location:578 → 642

I-set; Immunoglobulin I-set domain
XM_021477540.1 → XP_021333215.1 myosin-binding protein C, cardiac-type isoform X3

UniProtKB/TrEMBL

A0A8M9QH12

Conserved Domains (6) summary

smart00410
Location:177 → 272

IG_like; Immunoglobulin like

cd00063
Location:784 → 870

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:1193 → 1282

I-set; Immunoglobulin I-set domain

cd05748
Location:1002 → 1074

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar domains

cl11960
Location:673 → 780

Ig; Immunoglobulin domain

cl28434
Location:570 → 634

I-set; Immunoglobulin I-set domain
XM_009303217.3 → XP_009301492.1 myosin-binding protein C, cardiac-type isoform X4

UniProtKB/TrEMBL

A0A1L1QZU5, A0A8M3BB11

Related

ENSDARP00000143224.1, ENSDART00000174217.2

Conserved Domains (7) summary

cd00096
Location:1203 → 1267

Ig; Immunoglobulin domain

cd05748
Location:995 → 1067

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

smart00408
Location:478 → 536

IGc2; Immunoglobulin C-2 Type

smart00410
Location:986 → 1067

IG_like; Immunoglobulin like

cd00063
Location:777 → 863

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:1186 → 1275

I-set; Immunoglobulin I-set domain

cl11960
Location:666 → 773

Ig; Immunoglobulin domain
XM_009303219.3 → XP_009301494.1 myosin-binding protein C, cardiac-type isoform X6

UniProtKB/TrEMBL

A0A8M3AU87

Conserved Domains (7) summary

cd00096
Location:1195 → 1259

Ig; Immunoglobulin domain

cd05748
Location:987 → 1059

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

smart00408
Location:470 → 528

IGc2; Immunoglobulin C-2 Type

smart00410
Location:978 → 1059

IG_like; Immunoglobulin like

cd00063
Location:769 → 855

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:1178 → 1267

I-set; Immunoglobulin I-set domain

cl11960
Location:658 → 765

Ig; Immunoglobulin domain
XM_021477544.1 → XP_021333219.1 myosin-binding protein C, cardiac-type isoform X7

UniProtKB/TrEMBL

A0A8M9Q7W1

Conserved Domains (6) summary

smart00410
Location:87 → 182

IG_like; Immunoglobulin like

cd00063
Location:702 → 788

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:1111 → 1200

I-set; Immunoglobulin I-set domain

cd05748
Location:920 → 992

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar domains

cl11960
Location:591 → 698

Ig; Immunoglobulin domain

cl28434
Location:488 → 552

I-set; Immunoglobulin I-set domain
XM_009303221.3 → XP_009301496.1 myosin-binding protein C, cardiac-type isoform X8

UniProtKB/TrEMBL

A0A8M3B451

Conserved Domains (7) summary

cd00096
Location:1105 → 1169

Ig; Immunoglobulin domain

cd05748
Location:897 → 969

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

smart00408
Location:380 → 438

IGc2; Immunoglobulin C-2 Type

smart00410
Location:888 → 969

IG_like; Immunoglobulin like

cd00063
Location:679 → 765

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:1088 → 1177

I-set; Immunoglobulin I-set domain

cl11960
Location:568 → 675

Ig; Immunoglobulin domain

RNA

XR_002459139.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001080680.1: Suppressed sequence

Description

NM_001080680.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.