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asb4 ankyrin repeat and SOCS box containing 4 [ Danio rerio (zebrafish) ]

Gene ID: 550321, updated on 27-Mar-2024

Summary

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Official Symbol
asb4provided by ZNC
Official Full Name
ankyrin repeat and SOCS box containing 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-050417-100
See related
Ensembl:ENSDARG00000034988 AllianceGenome:ZFIN:ZDB-GENE-050417-100
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:110244
Summary
Predicted to be involved in protein ubiquitination. Predicted to act upstream of or within intracellular signal transduction. Orthologous to human ASB4 (ankyrin repeat and SOCS box containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 19
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (41169394..41182251)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (41582299..41595131)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene CAS1 domain containing 1 Neighboring gene sarcoglycan, epsilon Neighboring gene protein phosphatase 1, regulatory subunit 9A Neighboring gene pyruvate dehydrogenase kinase, isozyme 4 Neighboring gene dynein cytoplasmic 1 intermediate chain 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish Collagen Type I: Molecular and Biochemical Characterization of the Major Structural Protein in Bone and Skin. Gistelinck C, et al. Sci Rep, 2016 Feb 15. PMID 26876635, Free PMC Article
  2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ankyrin repeat and SOCS box protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017628.1 → NP_001017628.1  ankyrin repeat and SOCS box protein 4

    See identical proteins and their annotated locations for NP_001017628.1

    Status: PROVISIONAL

    Source sequence(s)
    BC092822
    UniProtKB/TrEMBL
    Q568K3
    Related
    ENSDARP00000048437.5, ENSDART00000048438.6
    Conserved Domains (4) summary
    cd00204
    Location:144 → 281
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03723
    Location:388 → 435
    SOCS_ASB4_ASB18; SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the ...
    pfam12796
    Location:121 → 214
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:116 → 147
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    41169394..41182251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159719.4 → XP_005159776.1  ankyrin repeat and SOCS box protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B6D1
    Conserved Domains (3) summary
    cd00204
    Location:144 → 281
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:121 → 214
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:116 → 147
    ANK; ANK repeat [structural motif]
Nucleotide Protein
Heading Accession and Version

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