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Conserved domains on  [gi|62955233|ref|NP_001017628|]
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ankyrin repeat and SOCS box protein 4 [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
89-303 3.57e-31

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 120.83  E-value: 3.57e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  89 LHVCMMYSALESAVVLLQNGAAVNRK-PNGKTPLHVACTVASADCVGLLLEWGARINSMSLSGHTPLHYCITPESLDCAK 167
Cdd:COG0666  58 LLAAALAGDLLVALLLLAAGADINAKdDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVK 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233 168 LLVLKGAKLNMPSEEHEdTPLHTAARYGLPELVAFYIAHGAAINAVNCYRETPLITAVfwamdirertySSDHHLVCRIL 247
Cdd:COG0666 138 LLLEAGADVNAQDNDGN-TPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAA-----------ENGHLEIVKLL 205

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 62955233 248 LDHNANLHMQEEDKKTALHKACWNCDHVLVQMLLEAGAQANDMDVNGCAAIQYVLK 303
Cdd:COG0666 206 LEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAA 261
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 388-435 2.21e-21

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239693  Cd Length: 48  Bit Score: 86.73  E-value: 2.21e-21
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 62955233 388 NNPRTPQHLSRCAIRAAMLKRCELGVQQLFLPTSVKKYLLLEPVGIIY 435
Cdd:cd03723   1 GTPRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLLLEPEGVLY 48
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
89-303 3.57e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 120.83  E-value: 3.57e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  89 LHVCMMYSALESAVVLLQNGAAVNRK-PNGKTPLHVACTVASADCVGLLLEWGARINSMSLSGHTPLHYCITPESLDCAK 167
Cdd:COG0666  58 LLAAALAGDLLVALLLLAAGADINAKdDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVK 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233 168 LLVLKGAKLNMPSEEHEdTPLHTAARYGLPELVAFYIAHGAAINAVNCYRETPLITAVfwamdirertySSDHHLVCRIL 247
Cdd:COG0666 138 LLLEAGADVNAQDNDGN-TPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAA-----------ENGHLEIVKLL 205

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 62955233 248 LDHNANLHMQEEDKKTALHKACWNCDHVLVQMLLEAGAQANDMDVNGCAAIQYVLK 303
Cdd:COG0666 206 LEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAA 261
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 388-435 2.21e-21

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 86.73  E-value: 2.21e-21
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 62955233 388 NNPRTPQHLSRCAIRAAMLKRCELGVQQLFLPTSVKKYLLLEPVGIIY 435
Cdd:cd03723   1 GTPRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLLLEPEGVLY 48
PHA03095 PHA03095
ankyrin-like protein; Provisional
 104-300 5.35e-17

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 82.77  E-value: 5.35e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  104 LLQNGAAVN-RKPNGKTPLHVACTVASADC---VGLLLEWGARINSMSLSGHTPLHYCIT-PESLDCAKLLVLKGAKLNM 178
Cdd:PHA03095  33 LLAAGADVNfRGEYGKTPLHLYLHYSSEKVkdiVRLLLEAGADVNAPERCGFTPLHLYLYnATTLDVIKLLIKAGADVNA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  179 PSEEHeDTPLHTAARyGL---PELVAFYIAHGAAINAVNCYRETPLitAVF---------------------WAMDIRER 234
Cdd:PHA03095 113 KDKVG-RTPLHVYLS-GFninPKVIRLLLRKGADVNALDLYGMTPL--AVLlksrnanvellrllidagadvYAVDDRFR 188

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62955233  235 TySSDHHL--------VCRILLDHNANLHMQEEDKKTALHKACW--NCDHVLVQMLLEAGAQANDMDVNGCAAIQY 300
Cdd:PHA03095 189 S-LLHHHLqsfkprarIVRELIRAGCDPAATDMLGNTPLHSMATgsSCKRSLVLPLLIAGISINARNRYGQTPLHY 263
Ank_2 pfam12796
Ankyrin repeats (3 copies);
121-214 7.35e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.98  E-value: 7.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233   121 LHVACTVASADCVGLLLEWGARINSMSLSGHTPLHYCITPESLDCAKLLvLKGAKLNMpsEEHEDTPLHTAARYGLPELV 200
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLL-LEHADVNL--KDNGRTALHYAARSGHLEIV 77

                          90
                  ....*....|....
gi 62955233   201 AFYIAHGAAINAVN 214
Cdd:pfam12796  78 KLLLEKGADINVKD 91
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 389-427 5.32e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 54.48  E-value: 5.32e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 62955233   389 NPRTPQHLSRCAIRAAMLKRCELGVQQLFLPTSVKKYLL 427
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 113-221 7.84e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 45.00  E-value: 7.84e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233 113 RKPNGKTPLHVACTVASADCVGLLLEwGAR--INSMSLS----GHTPLHYCITPESLDCAKLLVLKGAKLNMPSE----- 181
Cdd:cd22192  47 RGALGETALHVAALYDNLEAAVVLME-AAPelVNEPMTSdlyqGETALHIAVVNQNLNLVRELIARGADVVSPRAtgtff 125

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 62955233 182 -----------EHedtPLHTAARYGLPELVAFYIAHGAAINAVNCYRETPL 221
Cdd:cd22192 126 rpgpknliyygEH---PLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 394-429 1.09e-04

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 39.31  E-value: 1.09e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 62955233    394 QHLSRCAIRaamlkRCELGVQQLFLPTSVKKYLLLE 429
Cdd:smart00969   4 QHLCRLAIR-----RSLGGIDKLPLPPRLKDYLLYY 34
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 150-212 1.47e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 40.83  E-value: 1.47e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62955233   150 GHTPLHYCITPESLDCAKLLVLKGAKLN-------------MPSEEHEDTPLHTAARYGLPELVAFYIAHGAAINA 212
Cdd:TIGR00870 128 GITALHLAAHRQNYEIVKLLLERGASVParacgdffvksqgVDSFYHGESPLNAAACLGSPSIVALLSEDPADILT 203
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
89-303 3.57e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 120.83  E-value: 3.57e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  89 LHVCMMYSALESAVVLLQNGAAVNRK-PNGKTPLHVACTVASADCVGLLLEWGARINSMSLSGHTPLHYCITPESLDCAK 167
Cdd:COG0666  58 LLAAALAGDLLVALLLLAAGADINAKdDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVK 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233 168 LLVLKGAKLNMPSEEHEdTPLHTAARYGLPELVAFYIAHGAAINAVNCYRETPLITAVfwamdirertySSDHHLVCRIL 247
Cdd:COG0666 138 LLLEAGADVNAQDNDGN-TPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAA-----------ENGHLEIVKLL 205

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 62955233 248 LDHNANLHMQEEDKKTALHKACWNCDHVLVQMLLEAGAQANDMDVNGCAAIQYVLK 303
Cdd:COG0666 206 LEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAA 261
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
85-300 3.54e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 115.44  E-value: 3.54e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  85 WAMGLHVCMMYSALESAVVLLQNGAAVNRKPNGKTPLHVACTVASADCVGLLLEWGARINSMSLSGHTPLHYCITPESLD 164
Cdd:COG0666  22 ALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLE 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233 165 CAKLLVLKGAKLNMPSEEHEdTPLHTAARYGLPELVAFYIAHGAAINAVNCYRETPLITAVFwamdirertysSDHHLVC 244
Cdd:COG0666 102 IVKLLLEAGADVNARDKDGE-TPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA-----------NGNLEIV 169

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 62955233 245 RILLDHNANLHMQEEDKKTALHKACWNCDHVLVQMLLEAGAQANDMDVNGCAAIQY 300
Cdd:COG0666 170 KLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
4-298 4.92e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 112.35  E-value: 4.92e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233   4 LRAVLGLDEEEKRDQSRREAAGLLKARFLDALLRNDAAEVARILRTTSIDIDTVLDVEDRDMVLASYKQGYWLPSYKLET 83
Cdd:COG0666   6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  84 SWAMGLHVCMMYSALESAVVLLQNGAAVNRK-PNGKTPLHVACTVASADCVGLLLEWGARINSMSLSGHTPLHYCITPES 162
Cdd:COG0666  86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARdKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGN 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233 163 LDCAKLLVLKGAKLNMPSEEHEdTPLHTAARYGLPELVAFYIAHGAAINAVNCYRETPLITAVfwamdirertySSDHHL 242
Cdd:COG0666 166 LEIVKLLLEAGADVNARDNDGE-TPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAA-----------ENGNLE 233

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 62955233 243 VCRILLDHNANLHMQEEDKKTALHKACWNCDHVLVQMLLEAGAQANDMDVNGCAAI 298
Cdd:COG0666 234 IVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
97-325 2.12e-21

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 93.87  E-value: 2.12e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  97 ALESAVVLLQNGAAVNRKPNGKTPLHVACTVASADCVGLLLEWGARINSMSLSGHTPLHYCITPESLDCAKLLVLKGAKL 176
Cdd:COG0666   1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233 177 NMPSEEhEDTPLHTAARYGLPELVAFYIAHGAAINAVNCYRETPLITAVFwamdirertysSDHHLVCRILLDHNANLHM 256
Cdd:COG0666  81 NAKDDG-GNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAY-----------NGNLEIVKLLLEAGADVNA 148

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62955233 257 QEEDKKTALHKACWNCDHVLVQMLLEAGAQANDMDVNGCAAIQYVlkVTQIRPWAVpercyQLLLNYGA 325
Cdd:COG0666 149 QDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLA--AENGHLEIV-----KLLLEAGA 210
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 388-435 2.21e-21

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 86.73  E-value: 2.21e-21
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 62955233 388 NNPRTPQHLSRCAIRAAMLKRCELGVQQLFLPTSVKKYLLLEPVGIIY 435
Cdd:cd03723   1 GTPRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLLLEPEGVLY 48
PHA03095 PHA03095
ankyrin-like protein; Provisional
 104-300 5.35e-17

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 82.77  E-value: 5.35e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  104 LLQNGAAVN-RKPNGKTPLHVACTVASADC---VGLLLEWGARINSMSLSGHTPLHYCIT-PESLDCAKLLVLKGAKLNM 178
Cdd:PHA03095  33 LLAAGADVNfRGEYGKTPLHLYLHYSSEKVkdiVRLLLEAGADVNAPERCGFTPLHLYLYnATTLDVIKLLIKAGADVNA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  179 PSEEHeDTPLHTAARyGL---PELVAFYIAHGAAINAVNCYRETPLitAVF---------------------WAMDIRER 234
Cdd:PHA03095 113 KDKVG-RTPLHVYLS-GFninPKVIRLLLRKGADVNALDLYGMTPL--AVLlksrnanvellrllidagadvYAVDDRFR 188

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62955233  235 TySSDHHL--------VCRILLDHNANLHMQEEDKKTALHKACW--NCDHVLVQMLLEAGAQANDMDVNGCAAIQY 300
Cdd:PHA03095 189 S-LLHHHLqsfkprarIVRELIRAGCDPAATDMLGNTPLHSMATgsSCKRSLVLPLLIAGISINARNRYGQTPLHY 263
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 63-225 6.07e-17

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 82.41  E-value: 6.07e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233   63 RDMVLASYKQGYWLPSYKLETSWAMGLHVCMMYSA---LESAVVLLQNGAAVNRKPN-GKTPLHVACT--VASADCVGLL 136
Cdd:PHA03100  48 IDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLtdvKEIVKLLLEYGANVNAPDNnGITPLLYAISkkSNSYSIVEYL 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  137 LEWGARINSMSLSGHTPLHY---CITPEsLDCAKLLVLKGAKLNMPSE---------------EHEDTPLHTAARYGLPE 198
Cdd:PHA03100 128 LDNGANVNIKNSDGENLLHLyleSNKID-LKILKLLIDKGVDINAKNRvnyllsygvpinikdVYGFTPLHYAVYNNNPE 206

                        170       180
                 ....*....|....*....|....*..
gi 62955233  199 LVAFYIAHGAAINAVNCYRETPLITAV 225
Cdd:PHA03100 207 FVKYLLDLGANPNLVNKYGDTPLHIAI 233
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 104-308 1.24e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 81.55  E-value: 1.24e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  104 LLQNGAAVN-RKPNGKTPLHVACTVASADCVGLLLEWGARINSMSLSGHTPLHYCITPESLDCAKLLVLKGAKLNMpSEE 182
Cdd:PHA02874 110 ILDCGIDVNiKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANV-KDN 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  183 HEDTPLHTAARYGLPELVAFYIAHGAAInAVNCYRE-TPLITAVFWAMDIRErtyssdhhlvcriLLDHNANLHMQEEDK 261
Cdd:PHA02874 189 NGESPLHNAAEYGDYACIKLLIDHGNHI-MNKCKNGfTPLHNAIIHNRSAIE-------------LLINNASINDQDIDG 254

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 62955233  262 KTALHKAC-WNCDHVLVQMLLEAGAQANDMDVNG----CAAIQYVLKVTQIR 308
Cdd:PHA02874 255 STPLHHAInPPCDIDIIDILLYHKADISIKDNKGenpiDTAFKYINKDPVIK 306
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 104-250 3.11e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 74.15  E-value: 3.11e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  104 LLQNGAAVNrKPN--GKTPLHVACTVASADCVGLLLEWGARINSMSLSGHTPLHYCITP-ESLDCAKLLVLKGAKLNMPS 180
Cdd:PHA02878 187 LLSYGANVN-IPDktNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYcKDYDILKLLLEHGVDVNAKS 265

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  181 EEHEDTPLHTAARYglPELVAFYIAHGAAINAVNCYRETPLITAVFWAMDIRertyssdhhlVCRILLDH 250
Cdd:PHA02878 266 YILGLTALHSSIKS--ERKLKLLLEYGADINSLNSYKLTPLSSAVKQYLCIN----------IGRILISN 323
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 98-325 3.19e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 74.71  E-value: 3.19e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233   98 LESAVVLLQNGAAVNRKPNGK-TPLHVACTVAS-ADCVGLLLEWGARINSMSLSGHTPLhYCITPESLDCAKL--LVLKG 173
Cdd:PHA02876 253 LETSLLLYDAGFSVNSIDDCKnTPLHHASQAPSlSRLVPKLLERGADVNAKNIKGETPL-YLMAKNGYDTENIrtLIMLG 331

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  174 AKLNmPSEEHEDTPLHTAA---RYglPELVAFYIAHGAAINAVNCYRETPLITAVF------------WAMDIRERT--- 235
Cdd:PHA02876 332 ADVN-AADRLYITPLHQAStldRN--KDIVITLLELGANVNARDYCDKTPIHYAAVrnnvviintlldYGADIEALSqki 408

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  236 --------YSSDHHLVCRILLDHNANLHMQEEDKKTALHKACW-NCDHVLVQMLLEAGAQANDMDVNGCAAIQYVLKVTQ 306
Cdd:PHA02876 409 gtalhfalCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKkNCKLDVIEMLLDNGADVNAINIQNQYPLLIALEYHG 488

                        250
                 ....*....|....*....
gi 62955233  307 IrpwavpercYQLLLNYGA 325
Cdd:PHA02876 489 I---------VNILLHYGA 498
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 119-294 3.17e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 70.85  E-value: 3.17e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  119 TPLHVACTVASADCVGLLLEWGARINSMSLSGHTPLHYC-----ITPESLDCAKLLVLKGAKLNMPSEEHeDTPLHTAA- 192
Cdd:PHA03100  37 LPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLsnikyNLTDVKEIVKLLLEYGANVNAPDNNG-ITPLLYAIs 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  193 -RYGLPELVAFYIAHGAAINAVNCYRETPLITAVfwamdirerTYSSDHHLVCRILLDHNANL--------------HMQ 257
Cdd:PHA03100 116 kKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYL---------ESNKIDLKILKLLIDKGVDInaknrvnyllsygvPIN 186

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 62955233  258 EEDKK--TALHKACWNCDHVLVQMLLEAGAQANDMDVNG 294
Cdd:PHA03100 187 IKDVYgfTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYG 225
Ank_2 pfam12796
Ankyrin repeats (3 copies);
121-214 7.35e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.98  E-value: 7.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233   121 LHVACTVASADCVGLLLEWGARINSMSLSGHTPLHYCITPESLDCAKLLvLKGAKLNMpsEEHEDTPLHTAARYGLPELV 200
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLL-LEHADVNL--KDNGRTALHYAARSGHLEIV 77

                          90
                  ....*....|....
gi 62955233   201 AFYIAHGAAINAVN 214
Cdd:pfam12796  78 KLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
89-177 4.10e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 62.06  E-value: 4.10e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233    89 LHVCMMYSALESAVVLLQNGAAVN-RKPNGKTPLHVACTVASADCVGLLLEwGARINsMSLSGHTPLHYCITPESLDCAK 167
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANlQDKNGRTALHLAAKNGHLEIVKLLLE-HADVN-LKDNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|
gi 62955233   168 LLVLKGAKLN 177
Cdd:pfam12796  79 LLLEKGADIN 88
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 388-429 4.64e-12

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 60.20  E-value: 4.64e-12
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 62955233 388 NNPRTPQHLSRCAIRAAMLKRCELGVQQLFLPTSVKKYLLLE 429
Cdd:cd03716   1 STPRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLYE 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
188-291 7.01e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 61.29  E-value: 7.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233   188 LHTAARYGLPELVAFYIAHGAAINAVNCYRETPLITAVfwamdirertySSDHHLVCRILLDHnANLHMQeEDKKTALHK 267
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAA-----------KNGHLEIVKLLLEH-ADVNLK-DNGRTALHY 67

                          90       100
                  ....*....|....*....|....
gi 62955233   268 ACWNCDHVLVQMLLEAGAQANDMD 291
Cdd:pfam12796  68 AARSGHLEIVKLLLEKGADINVKD 91
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 389-429 2.69e-11

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 57.87  E-value: 2.69e-11
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 62955233 389 NPRTPQHLSRCAIRAAMLKRCELGVQQLFLPTSVKKYLLLE 429
Cdd:cd03587   1 NPRSLQHLCRLAIRRCLGKRRLDLIDKLPLPPRLKDYLLYK 41
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 43-286 1.29e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 63.54  E-value: 1.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233   43 VARILRTTSIDIDTVLDVEDRDMVLASYKQGYWLPSYKLETSWAMGLHVCMMYSALES---------------AVVLLQN 107
Cdd:PHA02876  88 VMDIVISLTLDCDIILDIKYASIILNKHKLDEACIHILKEAISGNDIHYDKINESIEYmklikeriqqdelliAEMLLEG 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  108 GAAVNRKP-NGKTPLHVACTVASADCVGLLLEWGARINSMSLSGHTPLHYCITPESLDCAKLLVLKGAKLNMPS------ 180
Cdd:PHA02876 168 GADVNAKDiYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKNDlsllka 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  181 ----------------------EEHEDTPLHTAARY-GLPELVAFYIAHGAAINAVNCYRETPLI-------------TA 224
Cdd:PHA02876 248 irnedletslllydagfsvnsiDDCKNTPLHHASQApSLSRLVPKLLERGADVNAKNIKGETPLYlmakngydtenirTL 327

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62955233  225 VFWAMDIR--ERTYSSDHHLVCRI---------LLDHNANLHMQEEDKKTALHKACWNCDHVLVQMLLEAGAQ 286
Cdd:PHA02876 328 IMLGADVNaaDRLYITPLHQASTLdrnkdivitLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGAD 400
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 99-254 1.34e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 63.54  E-value: 1.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233   99 ESAVVLLQNGAAVN-RKPNGKTPLHVACTVASADCVGLLLEWGARINSMSLSGHTPLHYCIT-PESLDCAKLLVLKGAKL 176
Cdd:PHA02876 356 DIVITLLELGANVNaRDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCgTNPYMSVKTLIDRGANV 435

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62955233  177 NmPSEEHEDTPLHTAARYGL-PELVAFYIAHGAAINAVNCYRETPLITAVfwamdirertyssDHHLVCRILLDHNANL 254
Cdd:PHA02876 436 N-SKNKDLSTPLHYACKKNCkLDVIEMLLDNGADVNAINIQNQYPLLIAL-------------EYHGIVNILLHYGAEL 500
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 389-427 5.32e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 54.48  E-value: 5.32e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 62955233   389 NPRTPQHLSRCAIRAAMLKRCELGVQQLFLPTSVKKYLL 427
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 167-303 5.32e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 58.05  E-value: 5.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  167 KLLVLKGAKLNMPSEEhEDTPLHTAARYGLPELVAFYIAHGAAINAVNCYRETPLITAV-FWAMDIRERTYSSD------ 239
Cdd:PHA02874  19 KIIKNKGNCINISVDE-TTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIkIGAHDIIKLLIDNGvdtsil 97

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62955233  240 -----HHLVCRILLDHNANLHMQEEDKKTALHKACWNCDHVLVQMLLEAGAQANDMDVNGCAAIQYVLK 303
Cdd:PHA02874  98 pipciEKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIK 166
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 74-298 6.09e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 57.69  E-value: 6.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233   74 YWLPSYKLETSWAmGLHVCMMYSALESAVVLLQNGAAVNRK-PNGKTPLHVACTVASADCVGLLLEWGARINSMSLS-GH 151
Cdd:PHA02875  25 GINPNFEIYDGIS-PIKLAMKFRDSEAIKLLMKHGAIPDVKyPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKdGM 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  152 TPLHYCITPESLDCAKLLVLKGAKLNMPSEEhEDTPLHTAARYGLPELVAFYIAHGAAINAVNCYRETPLITAVfwamdi 231
Cdd:PHA02875 104 TPLHLATILKKLDIMKLLIARGADPDIPNTD-KFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAM------ 176

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62955233  232 rertySSDHHLVCRILLDhnanlhmqeedkktalhkacwncdhvlvqmlleAGAQANDMDVNGCAAI 298
Cdd:PHA02875 177 -----AKGDIAICKMLLD---------------------------------SGANIDYFGKNGCVAA 205
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 167-325 1.49e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 56.43  E-value: 1.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  167 KLLVLKGAKLNMPSEEHEDTPLHTAARYGLPELVAFYIAHGAAINAVNCYRETPLITAVfwamdireRTYSSDhhlVCRI 246
Cdd:PHA02878 151 KLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAV--------KHYNKP---IVHI 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  247 LLDHNANLHMQEEDKKTALHKACWNC-DHVLVQMLLEAGAqandmDVNgcaAIQYVLKVTQIRPWAVPERCYQLLLNYGA 325
Cdd:PHA02878 220 LLENGASTDARDKCGNTPLHISVGYCkDYDILKLLLEHGV-----DVN---AKSYILGLTALHSSIKSERKLKLLLEYGA 291
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 104-178 4.09e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 55.06  E-value: 4.09e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62955233  104 LLQNGAAVNRKPN-GKTPLHVACTVASADCVGLLLEWGARINSMSLSGHTPLHYCITPESLDCAKLLVLKGAKLNM 178
Cdd:PHA03100 178 LLSYGVPINIKDVyGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKT 253
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 142-291 4.32e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 51.80  E-value: 4.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  142 RINSMSLSGHTPLHYCITPESLDCAKLLVLKGAKLNMPseEHED-TPLHTAARY----GLPELVAFYIAHG-----AAIN 211
Cdd:PHA02878  29 YSTSASLIPFIPLHQAVEARNLDVVKSLLTRGHNVNQP--DHRDlTPLHIICKEpnklGMKEMIRSINKCSvfytlVAIK 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  212 AVNCYRETPLITAVF-------WAMDIRE-RTYSSDHHL---VCRILLDHNANLHMQEEDK-KTALHKACWNCDHVLVQM 279
Cdd:PHA02878 107 DAFNNRNVEIFKIILtnrykniQTIDLVYiDKKSKDDIIeaeITKLLLSYGADINMKDRHKgNTALHYATENKDQRLTEL 186

                        170
                 ....*....|..
gi 62955233  280 LLEAGAQANDMD 291
Cdd:PHA02878 187 LLSYGANVNIPD 198
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 116-290 7.61e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 51.15  E-value: 7.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  116 NGKTPLHVACTVasadcvglllewgarinsmslsghtplhycitpESLDCAKLLVLKGAKLNMPSEEhEDTPLHTAARYG 195
Cdd:PHA02875 101 DGMTPLHLATIL---------------------------------KKLDIMKLLIARGADPDIPNTD-KFSPLHLAVMMG 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  196 LPELVAFYIAHGAAINAVNCYRETPLITAVfwamdirertySSDHHLVCRILLDHNANL-HMQEEDKKTALHKACWNCDH 274
Cdd:PHA02875 147 DIKGIELLIDHKACLDIEDCCGCTPLIIAM-----------AKGDIAICKMLLDSGANIdYFGKNGCVAALCYAIENNKI 215

                        170
                 ....*....|....*.
gi 62955233  275 VLVQMLLEAGAQANDM 290
Cdd:PHA02875 216 DIVRLFIKRGADCNIM 231
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 89-224 4.43e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 48.81  E-value: 4.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233   89 LHVCMMYSALESAVVLLQNGAAVNRKP-NGKTPLHVACTVASADCVGLLLEWGARINSMSLSGHTPLHYCITPESldCAK 167
Cdd:PHA02874 161 IHIAIKHNFFDIIKLLLEKGAYANVKDnNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNR--SAI 238

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 62955233  168 LLVLKGAKLNMpSEEHEDTPLHTAARYGLP-ELVAFYIAHGAAINAVNCYRETPLITA 224
Cdd:PHA02874 239 ELLINNASIND-QDIDGSTPLHHAINPPCDiDIIDILLYHKADISIKDNKGENPIDTA 295
Ank_2 pfam12796
Ankyrin repeats (3 copies);
89-146 1.71e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 43.18  E-value: 1.71e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 62955233    89 LHVCMMYSALESAVVLLQNgAAVNRKPNGKTPLHVACTVASADCVGLLLEWGARINSM 146
Cdd:pfam12796  34 LHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKLLLEKGADINVK 90
PHA03095 PHA03095
ankyrin-like protein; Provisional
 89-225 2.19e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 46.56  E-value: 2.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233   89 LHVCMMYSALESAV-VLLQNGAAVNRK-PNGKTPLHVACTVAS--ADCVGLLLEWGARINSMSLSGHTPLHYCI--TPES 162
Cdd:PHA03095  87 LHLYLYNATTLDVIkLLIKAGADVNAKdKVGRTPLHVYLSGFNinPKVIRLLLRKGADVNALDLYGMTPLAVLLksRNAN 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  163 LDCAKLLVLKGAKL------------------------------------------NMPSEEHED--------------- 185
Cdd:PHA03095 167 VELLRLLIDAGADVyavddrfrsllhhhlqsfkprarivreliragcdpaatdmlgNTPLHSMATgssckrslvlpllia 246

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 62955233  186 ------------TPLHTAARYGLPELVAFYIAHGAAINAVNCYRETPLITAV 225
Cdd:PHA03095 247 gisinarnrygqTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMV 298
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 103-169 3.12e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.43  E-value: 3.12e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62955233  103 VLLQNGAAVN-RKPNGKTPLHVACTVASADCVGLLLEWGARINSMSLSGHTPLHYCITPESLDCAKLL 169
Cdd:PTZ00322 100 ILLTGGADPNcRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 113-221 7.84e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 45.00  E-value: 7.84e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233 113 RKPNGKTPLHVACTVASADCVGLLLEwGAR--INSMSLS----GHTPLHYCITPESLDCAKLLVLKGAKLNMPSE----- 181
Cdd:cd22192  47 RGALGETALHVAALYDNLEAAVVLME-AAPelVNEPMTSdlyqGETALHIAVVNQNLNLVRELIARGADVVSPRAtgtff 125

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 62955233 182 -----------EHedtPLHTAARYGLPELVAFYIAHGAAINAVNCYRETPL 221
Cdd:cd22192 126 rpgpknliyygEH---PLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 131-249 8.22e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 44.20  E-value: 8.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  131 DCVGLLLEWGARINS---MSLSGHT-PLHYCITPESLDCAKLLVLKGAKLNMPSEEHEDTPLHTAARYGLPELVAFYIAH 206
Cdd:PHA02884  47 DIIDAILKLGADPEApfpLSENSKTnPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAKITPLYISVLHGCLKCLEILLSY 126

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 62955233  207 GAAINAVNCYRETPL-----ITAVFWAMDIRERTYSSDHHLVCRILLD 249
Cdd:PHA02884 127 GADINIQTNDMVTPIelalmICNNFLAFMICDNEISNFYKHPKKILIN 174
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 394-429 1.09e-04

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 39.31  E-value: 1.09e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 62955233    394 QHLSRCAIRaamlkRCELGVQQLFLPTSVKKYLLLE 429
Cdd:smart00969   4 QHLCRLAIR-----RSLGGIDKLPLPPRLKDYLLYY 34
Ank_5 pfam13857
Ankyrin repeats (many copies);
180-224 1.31e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.64  E-value: 1.31e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 62955233   180 SEEHEDTPLHTAARYGLPELVAFYIAHGAAINAVNCYRETPLITA 224
Cdd:pfam13857  12 LDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 89-213 1.52e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 43.83  E-value: 1.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233   89 LHVCMMYSALESAVVLLQNGAAVNRKPNGK-TPLHVACTVASADCVGLLLEWGARINSMSLSGHTPLHYCITPESLDCAK 167
Cdd:PHA02875 106 LHLATILKKLDIMKLLIARGADPDIPNTDKfSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICK 185

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 62955233  168 LLVLKGAKLNMPSEEHEDTPLHTAARYGLPELVAFYIAHGAAINAV 213
Cdd:PHA02875 186 MLLDSGANIDYFGKNGCVAALCYAIENNKIDIVRLFIKRGADCNIM 231
Ank_4 pfam13637
Ankyrin repeats (many copies);
223-281 3.17e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.41  E-value: 3.17e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 62955233   223 TAVFWAMdirertySSDHHLVCRILLDHNANLHMQEEDKKTALHKACWNCDHVLVQMLL 281
Cdd:pfam13637   3 TALHAAA-------ASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
119-170 9.18e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.25  E-value: 9.18e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 62955233   119 TPLHVACTVASADCVGLLLEWGARINSMSLSGHTPLHYCITPESLDCAKLLV 170
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 186-212 1.17e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.08  E-value: 1.17e-03
                          10        20
                  ....*....|....*....|....*..
gi 62955233   186 TPLHTAARYGLPELVAFYIAHGAAINA 212
Cdd:pfam13606   4 TPLHLAARNGRLEIVKLLLENGADINA 30
Ank_4 pfam13637
Ankyrin repeats (many copies);
150-202 1.28e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.87  E-value: 1.28e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 62955233   150 GHTPLHYCITPESLDCAKLLVLKGAKLNMPSEEHEdTPLHTAARYGLPELVAF 202
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGE-TALHFAASNGNVEVLKL 52
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 150-212 1.47e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 40.83  E-value: 1.47e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62955233   150 GHTPLHYCITPESLDCAKLLVLKGAKLN-------------MPSEEHEDTPLHTAARYGLPELVAFYIAHGAAINA 212
Cdd:TIGR00870 128 GITALHLAAHRQNYEIVKLLLERGASVParacgdffvksqgVDSFYHGESPLNAAACLGSPSIVALLSEDPADILT 203
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 89-220 1.48e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 39.80  E-value: 1.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233   89 LHVCM--MYSALESAVVLLQNGAAVNRKP--NGKTPLHVACTV---ASADCVGLLLEWGARINSMSLSGHTPLHYCITPE 161
Cdd:PHA02859  55 IFSCLekDKVNVEILKFLIENGADVNFKTrdNNLSALHHYLSFnknVEPEILKILIDSGSSITEEDEDGKNLLHMYMCNF 134

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62955233  162 S--LDCAKLLVLKGAKLnMPSEEHEDTPLHTAARY-GLPELVAFYIAHGAAINAVNCYRETP 220
Cdd:PHA02859 135 NvrINVIKLLIDSGVSF-LNKDFDNNNILYSYILFhSDKKIFDFLTSLGIDINETNKSGYNC 195
PHA02946 PHA02946
ankyin-like protein; Provisional
 104-188 1.76e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 40.42  E-value: 1.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  104 LLQNGAAVNRKPN-GKTPLHVACTVASADCVGLLLEWGARINSMSLSGHTPLHYC--ITPESLDCAKLLVLKGAKLNMPS 180
Cdd:PHA02946  58 LLHRGYSPNETDDdGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLsgTDDEVIERINLLVQYGAKINNSV 137


                 ....*...
gi 62955233  181 EEHEDTPL 188
Cdd:PHA02946 138 DEEGCGPL 145
PHA02798 PHA02798
ankyrin-like protein; Provisional
 96-290 2.08e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 40.20  E-value: 2.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233   96 SALESAVVLLQNGAAVNRK-PNGKTPLHvaC-----TVASADCVGLLLEWGARINSMSLSGHTPLHYCITPE---SLDCA 166
Cdd:PHA02798  87 HMLDIVKILIENGADINKKnSDGETPLY--CllsngYINNLEILLFMIENGADTTLLDKDGFTMLQVYLQSNhhiDIEII 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  167 KLLVLKGAKLNMPSEEHEDTPLHTAARYGLPEL----VAFYIAHGAAINAVNCYRETPLITAV----------------- 225
Cdd:PHA02798 165 KLLLEKGVDINTHNNKEKYDTLHCYFKYNIDRIdadiLKLFVDNGFIINKENKSHKKKFMEYLnsllydnkrfkknildf 244

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62955233  226 -FWAMDIRERT--------YSSDHH--LVCRILLDHNANLHMQEEDKKTALHKACWNCDHVLVQMLLEAGAQANDM 290
Cdd:PHA02798 245 iFSYIDINQVDelgfnplyYSVSHNnrKIFEYLLQLGGDINIITELGNTCLFTAFENESKFIFNSILNKKPNKNTI 320
SOCS_ASB8 cd03727
SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a ...
 390-428 2.40e-03

SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239697  Cd Length: 43  Bit Score: 35.58  E-value: 2.40e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 62955233 390 PRTPQHLSRCAIRAAmLKRCEL--GVQQLFLPTSVKKYLLL 428
Cdd:cd03727   3 PGTLKALARYAVRRS-LGVQYLpeAVKQLPLPRSVKEYLLL 42
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 128-206 2.44e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.27  E-value: 2.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  128 ASADCVG--LLLEWGARINSMSLSGHTPLHYCITPESLDCAKLLVLKGAKLNMPSEEhEDTPLHTAARYGLPELVAFYIA 205
Cdd:PTZ00322  91 ASGDAVGarILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKD-GKTPLELAEENGFREVVQLLSR 169


                 .
gi 62955233  206 H 206
Cdd:PTZ00322 170 H 170
Ank_4 pfam13637
Ankyrin repeats (many copies);
89-137 3.44e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.71  E-value: 3.44e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 62955233    89 LHVCMMYSALESAVVLLQNGAAVNRKP-NGKTPLHVACTVASADCVGLLL 137
Cdd:pfam13637   5 LHAAAASGHLELLRLLLEKGADINAVDgNGETALHFAASNGNVEVLKLLL 54
TRPV1 cd22196
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ...
 54-204 4.16e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411980 [Multi-domain]  Cd Length: 649  Bit Score: 39.40  E-value: 4.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233  54 IDTVLDVEDR-----DMVLASYKQGYwlpsYKLETSwamgLHVCMMYSALESAVVLLQNGAAVNRKPNGK---------- 118
Cdd:cd22196  66 ISLLLDIAEKtgnlkEFVNAAYTDSY----YKGQTA----LHIAIERRNMHLVELLVQNGADVHARASGEffkkkkggpg 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955233 119 -----TPLHVACTVASADCVGLLLE---WGARINSMSLSGHTPLHYCIT--PESLDCAKL-------LVLKGAKLNmPSE 181
Cdd:cd22196 138 fyfgeLPLSLAACTNQLDIVKFLLEnphSPADISARDSMGNTVLHALVEvaDNTPENTKFvtkmyneILILGAKIR-PLL 216

                       170       180       190
                ....*....|....*....|....*....|
gi 62955233 182 EHED-------TPLHTAARYGLPELVAFYI 204
Cdd:cd22196 217 KLEEitnkkglTPLKLAAKTGKIGIFAYIL 246
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 116-144 4.82e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.57  E-value: 4.82e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 62955233   116 NGKTPLHVACTVA-SADCVGLLLEWGARIN 144
Cdd:pfam00023   1 DGNTPLHLAAGRRgNLEIVKLLLSKGADVN 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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