GTSE1 G2 and S-phase expressed 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GTSE1provided by HGNC
Official Full Name: G2 and S-phase expressed 1provided by HGNC
Primary source: HGNC:HGNC:13698
See related: Ensembl:ENSG00000075218 MIM:607477; AllianceGenome:HGNC:13698
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: B99
Summary: The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008]
Expression: Broad expression in testis (RPKM 2.8), lymph node (RPKM 2.7) and 15 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 22q13.31

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	22	NC_000022.11 (46296870..46330810)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	22	NC_060946.1 (46781567..46815510)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	22	NC_000022.10 (46692767..46726707)

Chromosome 22 - NC_000022.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GTSE1 is possibly involved in the DNA damage repair and cisplatin resistance in osteosarcoma.
Title: GTSE1 is possibly involved in the DNA damage repair and cisplatin resistance in osteosarcoma.
Destabilization of Long Astral Microtubules via Cdk1-Dependent Removal of GTSE1 from Their Plus Ends Facilitates Prometaphase Spindle Orientation.
Title: Destabilization of Long Astral Microtubules via Cdk1-Dependent Removal of GTSE1 from Their Plus Ends Facilitates Prometaphase Spindle Orientation.
GTSE1 Facilitates the Malignant Phenotype of Lung Cancer Cells via Activating AKT/mTOR Signaling.
Title: GTSE1 Facilitates the Malignant Phenotype of Lung Cancer Cells via Activating AKT/mTOR Signaling.
Downregulation of GTSE1 leads to the inhibition of proliferation, migration, and Warburg effect in cervical cancer by blocking LHDA expression.
Title: Downregulation of GTSE1 leads to the inhibition of proliferation, migration, and Warburg effect in cervical cancer by blocking LHDA expression.
MiR-509-3-5p inhibits colon cancer malignancy by suppressing GTSE1.
Title: MiR-509-3-5p inhibits colon cancer malignancy by suppressing GTSE1.
GTSE1 promotes SNAIL1 degradation by facilitating its nuclear export in hepatocellular carcin oma cells.
Title: GTSE1 promotes SNAIL1 degradation by facilitating its nuclear export in hepatocellular carcin oma cells.
G2 and S phase-expressed-1 acts as a putative tumor promoter in cervical cancer by enhancing Wnt/beta-catenin signaling via modulation of GSK-3beta.
Title: G2 and S phase-expressed-1 acts as a putative tumor promoter in cervical cancer by enhancing Wnt/β-catenin signaling via modulation of GSK-3β.
GTSE1 promotes prostate cancer cell proliferation via the SP1/FOXM1 signaling pathway.
Title: GTSE1 promotes prostate cancer cell proliferation via the SP1/FOXM1 signaling pathway.
GTSE1, together with CDC20, PCNA, and MCM6, may synergistically promote adverse prognosis in hepatocellular carcinoma by activating cell cycle.
Title: GTSE1, CDC20, PCNA, and MCM6 Synergistically Affect Regulations in Cell Cycle and Indicate Poor Prognosis in Liver Cancer.
Authors found that GTSE1 could regulate the p53 function to alter the cell cycle distribution dependent on the mutation state of p53. Results reveal that GTSE1 played a key role in the progression of breast cancer.
Title: GTSE1 is involved in breast cancer progression in p53 mutation-dependent manner.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH93290 (e-PCR)
- UniSTS:90906

RH103350 (e-PCR)
- UniSTS:97681

RH93827 (e-PCR)
- UniSTS:90040

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	NAS Non-traceable Author Statement more info	PubMed
involved_in microtubule-based process	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasmic microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane	HDA more info	PubMed
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	TAS Traceable Author Statement more info

General protein information

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Preferred Names: G2 and S phase-expressed protein 1

Names: G-2 and S-phase expressed 1; Lnc_bc060912; protein B99 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016426.7 → NP_057510.5 G2 and S phase-expressed protein 1

Status: REVIEWED

Source sequence(s)

AL031588, Z93024

Consensus CDS

CCDS14074.2

UniProtKB/Swiss-Prot

B0QYM3, Q20WK2, Q53GX5, Q5R3I6, Q6DHX4, Q9BRE0, Q9NYZ3, Q9UGZ9, Q9Y557

UniProtKB/TrEMBL

B4DZT6

Related

ENSP00000415430.1, ENST00000454366.2

Conserved Domains (2) summary

pfam15259
Location:28 → 171

GTSE1_N; G-2 and S-phase expressed 1

cl26464
Location:169 → 662

Atrophin-1; Atrophin-1 family