Conserved Protein Domain Family
GTSE1_N
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pfam15259: GTSE1_N (this model, PSSM-Id:317641 is obsolete and has been replaced by 464599)
G-2 and S-phase expressed 1
This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S phase-expressed-1) protein is specifically expressed during S and G2 phases of the cell cycle. It is mainly localized to the microtubules and when overexpressed delays the G2 to M transition. the full protein negatively regulates p53 transactivation function, protein levels, and p53-dependent apoptosis. This domain family is found in eukaryotes, and is approximately 140 amino acids in length. There is a conserved FDFD sequence motif.
Links
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Statistics
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PSSM-Id: 317641
Aligned: 28 rows
Threshold Bit Score: 113.543
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_005988504   6 VTFITEEEFDFGFSFSNswedECD---Et---EDEIFVGPVKHLERCVAKSIDIN--IGNNESQRNNECLTNWSPPTADK 77  coelacanth
XP_011605872   9 LFFLHEEKFDFDMSMSPa---SSN---Gd---EDEVFVEPVGRNERCVSVNV--------KTQLDGRQLRTSWSPLTGDQ 71  torafugu
XP_014331064   8 LCFLQDEKFDFNVSLSPv---SSKgeeEd---DDEVF---VGHTEQCVSTDV------SSQPEEGGGDVQAVWTPLTADQ 72  southern platyfish
XP_011471173  28 VLFLQDEKFDFDVSLSPa---SSK---Dd---EDEVFEGPVEGEESRVSVS-------KASELLEGDHVFSNWSPLTGER 91  Japanese medaka
XP_016849676   1 ---------------------S----------DDEVFVGPMGHKEKCIAVLLE-SqeGPKNKCSPSAQDAPTWSPLAGEK 48  green anole
XP_003201973  29 FPLLADEKFDFDLSLSPs---SGS---E-----DEVFIGSLGHKEKCIAVNIE-AksAEKKK-VPTSDDKLTWSPLIGDK 95  turkey
XP_012424384  22 FPLLSDEKFDFDLSLSSt---SGN---E-----DEVFVGPMGHKERCIAASIE------AKKCVSAFDDKLTWSPLQGEK 84  zebra finch
XP_005010320  30 IPLLTDEKFDFDLSLSPa---SGN---E-----DEVFVGPLGHKEKCIAVSIEAKrsTEKSE--PASDEKLMWSPLTGEK 96  mallard
XP_005454251   9 VFFLPDEKFDFDVSLSPa---SSR---Gde-dEDEVFVGPVSHKEKCISVSV--------ASPLENHSI--TWSPLTGEQ 71  Nile tilapia
XP_005163070   9 FVSLAEEKFDFDVSLSPg---SSK---GdyevEDEVFVGPVSHKEKCISHGV-EThmKDNISSGPSLGEEPSWSPLTGEK 81  zebrafish

XP_005988504  78 LEEITREANQLAAQLEk---C-----TlkEKENSYRQKNDGSITNSFKFEKDTKGKIRLLKEERENRKSPrsPRRETYIV 149 coelacanth
XP_011605872  72 LEAVCQEAHKLANQLQsgerS-----QshSEDDKDNEATAAVTTQPDEFVQDSQAKLHVFEQSNR-VLSP--IKRETFCV 143 torafugu
XP_014331064  73 LEAVCEEAHRLASQLQ----CrephvQktNTTHTASDVDMNSMATTEEFIQDTEVKLGLLDHTAS-SLSP--IKRQTFCV 145 southern platyfish
XP_011471173  92 LDAVCQEAHSLVNQLQ----------------DGKACGVEDANIAGEQFLQDSEAKKKVLC-SSSGALSP--IKRQTFCV 152 Japanese medaka
XP_016849676  49 FVEIFKEAHLVALQLQ----S-----AskTKRKNAGQQEEAKSATVEKFVQESKSKLKILERGIVTNKTPtsIKRETFYV 119 green anole
XP_003201973  96 FVEIFKEAHLLALQIE----S-----GnkSEENKVSQSEGNGNETSEQFVEDLKSKMKILKSHHI-EKSPraVKRETYCV 165 turkey
XP_012424384  85 FVEIFKEAHLLALQIQ----T-----GskDEETKISQSEEQENKIIETFVEDSKSKLKILRNKNI-EISPrpAKRDTYCV 154 zebra finch
XP_005010320  97 FVEIFKEAHLLALQIE----R-----GskTEQDKISQAEEQEKEIIEKFVEDSKSKLKILRNENI-EQSPraAKRETYCV 166 mallard
XP_005454251  72 LEAVCQEAHRLASQLQs---T-----VshDENRDTTSMTMDTMTEQEEFVEDAETRLGLLAQTTS-GVSP--NKRQTFCV 140 Nile tilapia
XP_005163070  82 FDEICKEAQQLASHIEq------------TITDSAAESSVVSSCQTETFEDDAATKLNLFSKPAD-ILSP--IKRETFLV 146 zebrafish

XP_005988504 150 KDS 152 coelacanth
XP_011605872 144 QES 146 torafugu
XP_014331064 146 QDS 148 southern platyfish
XP_011471173 153 QDt 155 Japanese medaka
XP_016849676 120 AES 122 green anole
XP_003201973 166 GDS 168 turkey
XP_012424384 155 QDS 157 zebra finch
XP_005010320 167 WDS 169 mallard
XP_005454251 141 QDS 143 Nile tilapia
XP_005163070 147 QDS 149 zebrafish
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