U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hspa14 heat shock protein 14 [ Mus musculus (house mouse) ]

Gene ID: 50497, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Hspa14provided by MGI
Official Full Name
heat shock protein 14provided by MGI
Primary source
MGI:MGI:1354164
See related
Ensembl:ENSMUSG00000109865 AllianceGenome:MGI:1354164
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
70kDa; NST-1; hsr.1; HSP70L1; Hsp70-4
Summary
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and misfolded protein binding activity. Predicted to be involved in several processes, including cellular response to unfolded protein; chaperone cofactor-dependent protein refolding; and protein refolding. Predicted to be active in cytosol; nucleus; and plasma membrane. Predicted to colocalize with ribosome. Orthologous to human HSPA14 (heat shock protein family A (Hsp70) member 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 10.3), liver E14 (RPKM 9.7) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
2 A1; 2 1.97 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (3489891..3513851, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (3488854..3512814, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5880 Neighboring gene meiosis expressed gene 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:3341062-3341360 Neighboring gene DNA cross-link repair 1C Neighboring gene STARR-seq mESC enhancer starr_03514 Neighboring gene suppressor of variegation 3-9 2 Neighboring gene STARR-seq mESC enhancer starr_03515 Neighboring gene predicted gene, 54099 Neighboring gene Myb/SANT DNA binding domain containing 7 Neighboring gene STARR-positive B cell enhancer ABC_E272 Neighboring gene cerebral dopamine neurotrophic factor Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Toll-like receptor 4 (TLR4) is essential for Hsp70-like protein 1 (HSP70L1) to activate dendritic cells and induce Th1 response. Fang H, et al. J Biol Chem, 2011 Sep 2. PMID 21730052, Free PMC Article
  2. Sak kinase gene structure and transcriptional regulation. Hudson JW, et al. Gene, 2000 Jan 4. PMID 10607900
  3. Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice. Sferruzzi-Perri AN, et al. Biol Reprod, 2009 Jul. PMID 19228596, Free PMC Article
  4. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TLR4 is a key receptor mediating the interaction of Hsp70L1 with DCs and subsequently enhancing the induction of Th1 immune response by Hsp70L1/antigen fusion protein
    Title: Toll-like receptor 4 (TLR4) is essential for Hsp70-like protein 1 (HSP70L1) to activate dendritic cells and induce Th1 response.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with ribosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
heat shock 70 kDa protein 14
Names
heat shock 70kDa protein 14
heat shock protein 4
heat shock protein, 70 kDa 4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355397.1 → NP_001342326.1  heat shock 70 kDa protein 14 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL732620
    Conserved Domains (1) summary
    cl17037
    Location:27 → 329
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  2. NM_015765.2 → NP_056580.2  heat shock 70 kDa protein 14 isoform 1

    See identical proteins and their annotated locations for NP_056580.2

    Status: VALIDATED

    Source sequence(s)
    BI734146, BU505607, BY121986, U08215
    Consensus CDS
    CCDS15653.1
    UniProtKB/Swiss-Prot
    A2AJH7, Q3U5W7, Q60637, Q99M31
    Related
    ENSMUSP00000027961.6, ENSMUST00000027961.12
    Conserved Domains (1) summary
    cd10238
    Location:2 → 376
    HSPA14-like_NBD; Nucleotide-binding domain of human HSPA14 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    3489891..3513851 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001037542.1: Suppressed sequence

    Description
    NM_001037542.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

  2. NR_103465.1: Suppressed sequence

    Description
    NR_103465.1: This RefSeq was removed because it is now thought that this transcript does encode a protein.

  3. NR_149715.1: Suppressed sequence

    Description
    NR_149715.1: This RefSeq was removed because it is now thought that this transcript does encode a protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99M31.2 GenPept UniProtKB/Swiss-Prot:Q99M31

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous