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ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif 17 [ Canis lupus familiaris (dog) ]

Gene ID: 488708, updated on 5-Mar-2024

Summary

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Official Symbol
ADAMTS17provided by VGNC
Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif 17provided by VGNC
Primary source
VGNC:VGNC:37595
See related
Ensembl:ENSCAFG00845001303
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See ADAMTS17 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
23
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 3 NC_051807.1 (41014731..41340884)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 3 NC_006585.4 (43305552..43637568)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 3 NC_049224.1 (40986070..41324350)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 3 NC_049263.1 (40547918..40873550)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 3 NC_049744.1 (40778980..41104683)

Chromosome 3 - NC_051807.1Genomic Context describing neighboring genes Neighboring gene lines homolog 1 Neighboring gene ceramide synthase 3 Neighboring gene uncharacterized LOC111095194 Neighboring gene uncharacterized LOC111095193 Neighboring gene uncharacterized LOC119871195 Neighboring gene uncharacterized LOC102152741 Neighboring gene LysM domain containing 4 Neighboring gene myocyte enhancer factor 2A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Potential Modifying Loci Associated With Primary Lens Luxation, Pedal Hyperkeratosis, and Ocular Phenotypes in Miniature Bull Terriers. Gharahkhani P, et al. Invest Ophthalmol Vis Sci, 2015 Dec. PMID 26720482
  2. A Novel Genome-Wide Association Study Approach Using Genotyping by Exome Sequencing Leads to the Identification of a Primary Open Angle Glaucoma Associated Inversion Disrupting ADAMTS17. Forman OP, et al. PLoS One, 2015. PMID 26683476, Free PMC Article
  3. Two Independent Mutations in ADAMTS17 Are Associated with Primary Open Angle Glaucoma in the Basset Hound and Basset Fauve de Bretagne Breeds of Dog. Oliver JA, et al. PLoS One, 2015. PMID 26474315, Free PMC Article
  4. ADAMTS17 mutation associated with primary lens luxation is widespread among breeds. Gould D, et al. Vet Ophthalmol, 2011 Nov. PMID 22050825
  5. An ADAMTS17 splice donor site mutation in dogs with primary lens luxation. Farias FH, et al. Invest Ophthalmol Vis Sci, 2010 Sep. PMID 20375329

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results identified an inversion with a breakpoint disrupting the ADAMTS17 gene resulting in a cryptic splicing associated with primary open angle glaucoma in dogs.
    Title: A Novel Genome-Wide Association Study Approach Using Genotyping by Exome Sequencing Leads to the Identification of a Primary Open Angle Glaucoma Associated Inversion Disrupting ADAMTS17.
  2. Mutations in ADAMTS17 Are Associated with Primary Open Angle Glaucoma.
    Title: Two Independent Mutations in ADAMTS17 Are Associated with Primary Open Angle Glaucoma in the Basset Hound and Basset Fauve de Bretagne Breeds of Dog.
  3. Association of the ADAMTS17 mutation with possible pedal skeletal abnormalities in MBTs supports PLL in this breed and Weill-Marchesani syndrome-like disease in humans as being homologous diseases.
    Title: Potential Modifying Loci Associated With Primary Lens Luxation, Pedal Hyperkeratosis, and Ocular Phenotypes in Miniature Bull Terriers.
  4. frequency of c.1473+1 G>A mutation in different breeds and relation to primary lens luxation
    Title: ADAMTS17 mutation associated with primary lens luxation is widespread among breeds.
  5. The primary lens luxation locus was mapped to a 664-kb region of canine chromosome 3 containing regional candidate gene ADAMTS17
    Title: An ADAMTS17 splice donor site mutation in dogs with primary lens luxation.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 17

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051807.1 Reference ROS_Cfam_1.0

    Range
    41014731..41340884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038661189.1 → XP_038517117.1  A disintegrin and metalloproteinase with thrombospondin motifs 17

    UniProtKB/TrEMBL
    A0A8C0LYI9, A0A8I3MIA8
    Related
    ENSCAFP00845001785.1, ENSCAFT00845002253.1
    Conserved Domains (6) summary
    smart00209
    Location:546 → 598
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:232 → 449
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:700 → 810
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:36 → 180
    Pep_M12B_propep; Reprolysin family propeptide
    pfam17771
    Location:466 → 533
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:1003 → 1050
    TSP1_ADAMTS; Thrombospondin type 1 domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049263.1 Alternate UMICH_Zoey_3.1

    Range
    40547918..40873550
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038471746.1 → XP_038327674.1  A disintegrin and metalloproteinase with thrombospondin motifs 17

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049744.1 Alternate UNSW_CanFamBas_1.0

    Range
    40778980..41104683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038596979.1 → XP_038452907.1  A disintegrin and metalloproteinase with thrombospondin motifs 17

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049224.1 Alternate UU_Cfam_GSD_1.0

    Range
    40986070..41324350
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038532673.1 → XP_038388601.1  A disintegrin and metalloproteinase with thrombospondin motifs 17

    UniProtKB/TrEMBL
    A0A8P0SFN4

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006585.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    43305552..43637568
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014112383.3 → XP_013967858.1  A disintegrin and metalloproteinase with thrombospondin motifs 17

    UniProtKB/TrEMBL
    A0A8P0SFN4
    Conserved Domains (7) summary
    smart00209
    Location:546 → 598
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:232 → 449
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam00090
    Location:895 → 948
    TSP_1; Thrombospondin type 1 domain
    pfam01421
    Location:232 → 449
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:81 → 180
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:700 → 810
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:1082 → 1108
    PLAC; PLAC (protease and lacunin) domain
Nucleotide Protein
Heading Accession and Version

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