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APLP2 amyloid beta precursor like protein 2 [ Canis lupus familiaris (dog) ]

Gene ID: 479393, updated on 5-Mar-2024

Summary

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Official Symbol
APLP2provided by VGNC
Official Full Name
amyloid beta precursor like protein 2provided by VGNC
Primary source
VGNC:VGNC:37989
See related
Ensembl:ENSCAFG00845006750
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
18
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (4663992..4746091, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (4764879..4846709, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (4734652..4816738, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (4725302..4807340, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (4706890..4788998, complement)

Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 44 Neighboring gene ST14 transmembrane serine protease matriptase Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene PR/SET domain 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transition metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in axonogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in central nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
amyloid-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051809.1 Reference ROS_Cfam_1.0

    Range
    4663992..4746091 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038664384.1 → XP_038520312.1  amyloid-like protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0YWP7
    Conserved Domains (3) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam12925
    Location:309 → 491
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:612 → 692
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  2. XM_038664383.1 → XP_038520311.1  amyloid-like protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KAU9, A0A8C0YWP7, A0A8C0YWW2, A0A8I3MVF1
    Related
    ENSCAFP00845009415.1, ENSCAFT00845012061.1
    Conserved Domains (3) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam12925
    Location:309 → 491
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:624 → 704
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  3. XM_038664382.1 → XP_038520310.1  amyloid-like protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0K856, A0A8C0SDW3, A0A8C0YWP7, A0A8I3N111
    Related
    ENSCAFP00845009483.1, ENSCAFT00845012138.1
    Conserved Domains (4) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam00014
    Location:309 → 361
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam12925
    Location:365 → 547
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:668 → 748
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  4. XM_038664381.1 → XP_038520309.1  amyloid-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KAT9, A0A8C0M5I6, A0A8C0YWP7, A0A8I3N3Q6
    Related
    ENSCAFP00845009357.1, ENSCAFT00845011992.1
    Conserved Domains (4) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam00014
    Location:309 → 361
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam12925
    Location:365 → 547
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:680 → 760
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049265.1 Alternate UMICH_Zoey_3.1

    Range
    4725302..4807340 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038474512.1 → XP_038330440.1  amyloid-like protein 2 isoform X4

    Conserved Domains (3) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam12925
    Location:309 → 491
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:612 → 692
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  2. XM_038474511.1 → XP_038330439.1  amyloid-like protein 2 isoform X3

    Conserved Domains (3) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam12925
    Location:309 → 491
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:624 → 704
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  3. XM_038474510.1 → XP_038330438.1  amyloid-like protein 2 isoform X2

    Conserved Domains (4) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam00014
    Location:309 → 361
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam12925
    Location:365 → 547
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:668 → 748
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  4. XM_038474509.1 → XP_038330437.1  amyloid-like protein 2 isoform X1

    Conserved Domains (4) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam00014
    Location:309 → 361
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam12925
    Location:365 → 547
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:680 → 760
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

    Range
    4706890..4788998 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038599841.1 → XP_038455769.1  amyloid-like protein 2 isoform X4

    Conserved Domains (3) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam12925
    Location:309 → 491
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:612 → 692
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  2. XM_038599840.1 → XP_038455768.1  amyloid-like protein 2 isoform X3

    Conserved Domains (3) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam12925
    Location:309 → 491
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:624 → 704
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  3. XM_038599839.1 → XP_038455767.1  amyloid-like protein 2 isoform X2

    Conserved Domains (4) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam00014
    Location:309 → 361
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam12925
    Location:365 → 547
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:668 → 748
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  4. XM_038599838.1 → XP_038455766.1  amyloid-like protein 2 isoform X1

    Conserved Domains (4) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam00014
    Location:309 → 361
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam12925
    Location:365 → 547
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:680 → 760
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

    Range
    4734652..4816738 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038535634.1 → XP_038391562.1  amyloid-like protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0YWP7
    Conserved Domains (3) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam12925
    Location:309 → 491
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:612 → 692
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  2. XM_038535633.1 → XP_038391561.1  amyloid-like protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KAU9, A0A8C0YWP7, A0A8C0YWW2, A0A8I3MVF1
    Conserved Domains (3) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam12925
    Location:309 → 491
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:624 → 704
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  3. XM_038535632.1 → XP_038391560.1  amyloid-like protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0K856, A0A8C0SDW3, A0A8C0YWP7, A0A8I3N111
    Conserved Domains (4) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam00014
    Location:309 → 361
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam12925
    Location:365 → 547
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:668 → 748
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  4. XM_038535631.1 → XP_038391559.1  amyloid-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KAT9, A0A8C0M5I6, A0A8C0YWP7, A0A8I3N3Q6
    Conserved Domains (4) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam00014
    Location:309 → 361
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam12925
    Location:365 → 547
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:680 → 760
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    4764879..4846709 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005619552.4 → XP_005619609.1  amyloid-like protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0YWP7
    Conserved Domains (3) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam12925
    Location:309 → 491
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:612 → 692
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  2. XM_005619551.4 → XP_005619608.1  amyloid-like protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KAU9, A0A8C0YWP7, A0A8C0YWW2, A0A8I3MVF1
    Conserved Domains (3) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam12925
    Location:309 → 491
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:624 → 704
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  3. XM_005619550.4 → XP_005619607.1  amyloid-like protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0K856, A0A8C0SDW3, A0A8C0YWP7, A0A8I3N111
    Conserved Domains (4) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam00014
    Location:309 → 361
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam12925
    Location:365 → 547
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:668 → 748
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  4. XM_536530.7 → XP_536530.2  amyloid-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KAT9, A0A8C0M5I6, A0A8C0YWP7, A0A8I3N3Q6
    Conserved Domains (4) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam00014
    Location:309 → 361
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam12925
    Location:365 → 547
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:680 → 760
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins
Nucleotide Protein
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