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APP amyloid beta precursor protein [ Pan troglodytes (chimpanzee) ]

Gene ID: 473931, updated on 29-Mar-2024

Summary

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Official Symbol
APPprovided by VGNC
Official Full Name
amyloid beta precursor proteinprovided by VGNC
Primary source
VGNC:VGNC:6591
Locus tag
CK820_G0018224
See related
Ensembl:ENSPTRG00000013811
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 21
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 22 NC_072420.2 (26667179..26951990, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 21 NC_072419.1 (24299610..24584412, complement)

Chromosome 22 - NC_072420.2Genomic Context describing neighboring genes Neighboring gene protein LLP homolog Neighboring gene ATP synthase peripheral stalk subunit F6 Neighboring gene GA binding protein transcription factor subunit alpha Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134809245 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC129138315 Neighboring gene cysteine and tyrosine rich 1 Neighboring gene ribosomal protein lateral stalk subunit P1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Accelerated evolution of nervous system genes in the origin of Homo sapiens. Dorus S, et al. Cell, 2004 Dec 29. PMID 15620360
  2. Major chimpanzee-specific structural changes in sperm development-associated genes. Kim RN, et al. Funct Integr Genomics, 2011 Sep. PMID 21484476

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transition metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in axonogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in central nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
amyloid-beta precursor protein
Names
ABPP
Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimers disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4)
alzheimer disease amyloid A4 protein homolog
alzheimer disease amyloid protein
amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)
amyloid precursor protein
amyloid-beta (A4) precursor protein
beta-amyloid precursor protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013018.1 → NP_001013036.1  amyloid-beta precursor protein precursor

    See identical proteins and their annotated locations for NP_001013036.1

    Status: PROVISIONAL

    Source sequence(s)
    AY665248
    UniProtKB/Swiss-Prot
    Q5IS80
    UniProtKB/TrEMBL
    A0A2I3REJ9, A0A2J8MQ72
    Related
    ENSPTRP00000079656.1, ENSPTRT00000094583.1
    Conserved Domains (5) summary
    smart00006
    Location:24 → 188
    A4_EXTRA; amyloid A4
    pfam00014
    Location:294 → 341
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam03494
    Location:677 → 713
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:716 → 766
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:366 → 548
    APP_E2; E2 domain of amyloid precursor protein

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072420.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    26667179..26951990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009451769.5 → XP_009450044.1  amyloid-beta precursor protein isoform X2

    See identical proteins and their annotated locations for XP_009450044.1

    UniProtKB/TrEMBL
    A0A2I3S056, A0A2I3TSR6, A0A2J8MQ81, A0A2J8MQ85, A0A6D2WH19, A0A6D2WLX6
    Related
    ENSPTRP00000070245.1
    Conserved Domains (4) summary
    smart00006
    Location:24 → 188
    A4_EXTRA; amyloid A4
    pfam00014
    Location:294 → 342
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam12925
    Location:347 → 529
    APP_E2; E2 domain of amyloid precursor protein
    cl41775
    Location:674 → 748
    JMTM_Notch_APP; juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins

  2. XM_009452766.5 → XP_009451041.1  amyloid-beta precursor protein isoform X4

    See identical proteins and their annotated locations for XP_009451041.1

    UniProtKB/TrEMBL
    A0A2I3SHN1, A0A2I3SP96, A0A2J8MQ68, A0A6D2X899
    Related
    ENSPTRP00000076007.1
    Conserved Domains (3) summary
    smart00006
    Location:24 → 188
    A4_EXTRA; amyloid A4
    pfam12925
    Location:291 → 473
    APP_E2; E2 domain of amyloid precursor protein
    cl41775
    Location:618 → 692
    JMTM_Notch_APP; juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins

  3. XM_009453143.5 → XP_009451418.1  amyloid-beta precursor protein isoform X5

    See identical proteins and their annotated locations for XP_009451418.1

    UniProtKB/TrEMBL
    A0A2I3SP96
    Conserved Domains (3) summary
    smart00006
    Location:24 → 188
    A4_EXTRA; amyloid A4
    pfam12925
    Location:291 → 473
    APP_E2; E2 domain of amyloid precursor protein
    cl41775
    Location:600 → 674
    JMTM_Notch_APP; juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins

  4. XM_009452222.5 → XP_009450497.1  amyloid-beta precursor protein isoform X3

    See identical proteins and their annotated locations for XP_009450497.1

    UniProtKB/TrEMBL
    A0A2I3TSR6, A0A2J8MQ81, A0A6D2WH19
    Conserved Domains (4) summary
    smart00006
    Location:24 → 188
    A4_EXTRA; amyloid A4
    pfam00014
    Location:294 → 342
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam12925
    Location:347 → 529
    APP_E2; E2 domain of amyloid precursor protein
    cl41775
    Location:656 → 730
    JMTM_Notch_APP; juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins

  5. XM_009451357.5 → XP_009449632.1  amyloid-beta precursor protein isoform X1

    UniProtKB/TrEMBL
    A0A2I3REJ9, A0A2J8MQ65, A0A2K6HIQ8, A0A6D2XM07
    Related
    ENSPTRP00000023795.4
    Conserved Domains (4) summary
    smart00006
    Location:24 → 188
    A4_EXTRA; amyloid A4
    pfam00014
    Location:294 → 342
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam12925
    Location:366 → 548
    APP_E2; E2 domain of amyloid precursor protein
    cl41775
    Location:675 → 749
    JMTM_Notch_APP; juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5IS80.1 GenPept UniProtKB/Swiss-Prot:Q5IS80

Gene LinkOut

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