4BQD,1KTH,3L3T,5EZD,1IRH,1ZR0,1TFX,4U32,5H7V


Conserved Protein Domain Family
Kunitz_BPTI
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pfam00014: Kunitz_BPTI (this model, PSSM-Id:333766 is obsolete and has been replaced by 425421)
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Kunitz/Bovine pancreatic trypsin inhibitor domain
Indicative of a protease inhibitor, usually a serine protease inhibitor. Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure. Certain family members are similar to the tick anticoagulant peptide (TAP). This is a highly selective inhibitor of factor Xa in the blood coagulation pathways. TAP molecules are highly dipolar, and are arranged to form a twisted two- stranded antiparallel beta-sheet followed by an alpha helix.
Links
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Statistics
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PSSM-Id: 333766
Aligned: 109 rows
Threshold Bit Score: 52.6317
Created: 18-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4BQD_A      25 FCAFKA-DDG--P-CKa------IM--KRFFFNIFTRQCEEFIYGGCEGN--QNRFESLEECKKMC 76   human
Q18761      99 LCLLDA-DQG--H-CGde---rnGH--WWYFFNQESGECEKFFYYGCGGN--DNKFYSLHMCRKVC 153  Caenorhabditis elegans
Q19305     621 ICQEDK-QAG--Q-CAg------NF--PRYWYNHEKTQCERFIFTGCKGN--RNQFETEEECKQIC 672  Caenorhabditis elegans
O45881    1286 RCSFDK-DSG--S-GKg------YN--VKWYFNMKNLRCEQFVFEGLGGN--TNQFETLSECERIC 1337 Caenorhabditis elegans
O45881    2116 VCQIKP-SEGr-V-CNdsetptrTN--LQYFYSPRDNRCKLFFFRGCGGN--LNRFERKSDCEALC 2174 Caenorhabditis elegans
P00978     286 ACNLPI-VQG--P-CRs------YI--QLWAFDAVKGKCVRFSYGGCKGN--GNKFYSEKECKEYC 337  cattle
Q21418     410 VCKLPR-EQG--N-CGt------YS--NRWWFNAKTGNCEEFIYSGCQGN--ANNFETYKECQDYC 461  Caenorhabditis elegans
P48307      95 VCRLQV-SVDd-Q-CEg------ST--EKYFFNLSSMTCEKFFSGGCHRNriENRFPDEATCMGFC 149  human
NP_989345  280 ACRLPI-TPG--P-CKa------AK--THWAFDAAQGKCVTFAYGGCQGN--GNQFYTEKECKEYC 331  tropical clawed frog
Q94164      22 RCSKSIfDSNltAkCE-------KSstIKFHFDQSTGLCMNFRWDGCKDQ--ENKFDSLQECASTC 78   Caenorhabditis elegans
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