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Agpat3 1-Acylglycerol-3-phosphate O-acyltransferase 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39820, updated on 26-Apr-2024

Summary

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Official Symbol
Agpat3provided by FlyBase
Official Full Name
1-Acylglycerol-3-phosphate O-acyltransferase 3provided by FlyBase
Primary source
FLYBASE:FBgn0036623
Locus tag
Dmel_CG4729
See related
AllianceGenome:FB:FBgn0036623
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AGPAT; AGPAT-3; AGPAT3; CG4729; DmAGPAT3-5; Dmel\CG4729
Summary
Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity. Located in endomembrane system. Is expressed in several structures, including adult heart; anterior-posterior subdivision of organism; embryonic/larval midgut; endoderm; and germ layer derivative. Orthologous to human AGPAT3 (1-acylglycerol-3-phosphate O-acyltransferase 3) and AGPAT4 (1-acylglycerol-3-phosphate O-acyltransferase 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
72E4-72E4; 3-44 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16381772..16385957, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16374872..16379057, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene roquin Neighboring gene 1-Acylglycerol-3-phosphate O-acyltransferase 4 Neighboring gene RING-associated factor 2 Neighboring gene uncharacterized protein Neighboring gene Gag-related

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila Lipin interacts with insulin and TOR signaling pathways in the control of growth and lipid metabolism. Schmitt S, et al. J Cell Sci, 2015 Dec 1. PMID 26490996
  2. Coordinated control of adiposity and growth by anti-anabolic kinase ERK7. Hasygar K, et al. EMBO Rep, 2021 Feb 3. PMID 33369866, Free PMC Article
  3. Determinants of Endoplasmic Reticulum-to-Lipid Droplet Protein Targeting. Olarte MJ, et al. Dev Cell, 2020 Aug 24. PMID 32730754, Free PMC Article
  4. Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. Wilfling F, et al. Dev Cell, 2013 Feb 25. PMID 23415954, Free PMC Article
  5. MAAMD: a workflow to standardize meta-analyses and comparison of affymetrix microarray data. Gan Z, et al. BMC Bioinformatics, 2014 Mar 12. PMID 24621103, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endomembrane system HDA PubMed 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
1-Acylglycerol-3-phosphate O-acyltransferase 3
Names
Agpat3-PA
Agpat3-PB
Agpat3-PC
Agpat3-PD
Agpat3-PE
CG4729-PA
CG4729-PB
CG4729-PC
CG4729-PD
CG4729-PE
NP_001246793.1
NP_648888.1
NP_730160.1
NP_730161.1
NP_730162.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    16381772..16385957 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140631.2 → NP_648888.1  1-Acylglycerol-3-phosphate O-acyltransferase 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648888.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VV50, Q9VV51
    Related
    FBpp0075175
    Conserved Domains (3) summary
    cd07990
    Location:64 → 260
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    PLN02380
    Location:12 → 376
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
    pfam16076
    Location:247 → 325
    Acyltransf_C; Acyltransferase C-terminus

  2. NM_001259864.1 → NP_001246793.1  1-Acylglycerol-3-phosphate O-acyltransferase 3, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246793.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D5AEK7
    Conserved Domains (3) summary
    cd07990
    Location:75 → 271
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    PLN02380
    Location:23 → 387
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
    pfam16076
    Location:258 → 336
    Acyltransf_C; Acyltransferase C-terminus

  3. NM_168662.2 → NP_730161.1  1-Acylglycerol-3-phosphate O-acyltransferase 3, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730161.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VV50, Q9VV51
    Related
    FBpp0075176
    Conserved Domains (3) summary
    cd07990
    Location:64 → 260
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    PLN02380
    Location:12 → 376
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
    pfam16076
    Location:247 → 325
    Acyltransf_C; Acyltransferase C-terminus

  4. NM_168661.2 → NP_730160.1  1-Acylglycerol-3-phosphate O-acyltransferase 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730160.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VV50, Q9VV51
    Related
    FBpp0075177
    Conserved Domains (3) summary
    cd07990
    Location:64 → 260
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    PLN02380
    Location:12 → 376
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
    pfam16076
    Location:247 → 325
    Acyltransf_C; Acyltransferase C-terminus

  5. NM_168663.2 → NP_730162.1  1-Acylglycerol-3-phosphate O-acyltransferase 3, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730162.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961F9
    Related
    FBpp0075178
    Conserved Domains (1) summary
    pfam16076
    Location:4 → 82
    Acyltransf_C; Acyltransferase C-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D5AEK7 D5AEK7
Q961F9 Q961F9
Q9VV51 Q9VV51

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