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pals2b protein associated with LIN7 2, MAGUK p55 family member b [ Danio rerio (zebrafish) ]

Gene ID: 394134, updated on 27-Mar-2024

Summary

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Official Symbol
pals2bprovided by ZNC
Official Full Name
protein associated with LIN7 2, MAGUK p55 family member bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-775
See related
Ensembl:ENSDARG00000029761 AllianceGenome:ZFIN:ZDB-GENE-040426-775
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mpp6; mpp6b; zgc:55662
Summary
Acts upstream of or within glial cell development and retina development in camera-type eye. Is expressed in epiphysis and retina. Orthologous to human PALS2 (protein associated with LIN7 2, MAGUK p55 family member). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 19
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (20060205..20106486, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (20475882..20522163, complement)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 3a Neighboring gene gasdermin Ea Neighboring gene uncharacterized LOC110438148 Neighboring gene neuropeptide Y

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells. Giera S, et al. Elife, 2018 May 29. PMID 29809138, Free PMC Article
  2. Evolution of gonadotropin-inhibitory hormone receptor and its ligand. Ubuka T, et al. Gen Comp Endocrinol, 2014 Dec 1. PMID 25220854
  3. Structural diversity of the GnIH/GnIH receptor system in teleost: its involvement in early development and the negative control of LH release. Zhang Y, et al. Peptides, 2010 Jun. PMID 20226824
  4. The zebrafish NLRP3 inflammasome has functional roles in ASC-dependent interleukin-1β maturation and gasdermin E-mediated pyroptosis. Li JY, et al. J Biol Chem, 2020 Jan 24. PMID 31852739, Free PMC Article
  5. Evolution of the neuropeptide Y family: new genes by chromosome duplications in early vertebrates and in teleost fishes. Sundström G, et al. Gen Comp Endocrinol, 2008 Feb 1. PMID 17950734

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC55662

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within glial cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
MAGUK p55 subfamily member 6; MAGUK p55 subfamily member 6b
Names
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
membrane protein, palmitoylated 6b (MAGUK p55 subfamily member 6)
protein associated with LIN7 2, MAGUK family member b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044777.1 → NP_001038242.1  MAGUK p55 subfamily member 6b

    Status: PROVISIONAL

    Source sequence(s)
    BX640464
    UniProtKB/TrEMBL
    A0A8M1N987, F6P9A3, Q1LW94
    Related
    ENSDARP00000043923.5, ENSDART00000043924.7
    Conserved Domains (5) summary
    smart00569
    Location:2 → 55
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd11862
    Location:219 → 276
    SH3_MPP; Src Homology 3 domain of Membrane Protein, Palmitoylated (or MAGUK p55 subfamily member) proteins
    cd00992
    Location:128 → 206
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02828
    Location:57 → 108
    L27; L27 domain
    cl27059
    Location:336 → 526
    Guanylate_kin; Guanylate kinase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    20060205..20106486 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021468023.1 → XP_021323698.1  MAGUK p55 subfamily member 6 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PAV5
    Conserved Domains (5) summary
    smart00569
    Location:6 → 59
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd11862
    Location:223 → 280
    SH3_MPP; Src Homology 3 domain of Membrane Protein, Palmitoylated (or MAGUK p55 subfamily member) proteins
    cd00992
    Location:132 → 210
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02828
    Location:61 → 112
    L27; L27 domain
    cl27059
    Location:340 → 530
    Guanylate_kin; Guanylate kinase

  2. XM_005170013.4 → XP_005170070.1  MAGUK p55 subfamily member 6 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BHB1
    Conserved Domains (6) summary
    smart00569
    Location:43 → 96
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd11862
    Location:260 → 317
    SH3_MPP; Src Homology 3 domain of Membrane Protein, Palmitoylated (or MAGUK p55 subfamily member) proteins
    smart00072
    Location:387 → 568
    GuKc; Guanylate kinase homologues
    cd00992
    Location:169 → 247
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:377 → 567
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:98 → 149
    L27; L27 domain

  3. XM_021468024.1 → XP_021323699.1  MAGUK p55 subfamily member 6 isoform X3

    UniProtKB/TrEMBL
    A0A8M1N987, F6P9A3, Q1LW94
    Conserved Domains (5) summary
    smart00569
    Location:2 → 55
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd11862
    Location:219 → 276
    SH3_MPP; Src Homology 3 domain of Membrane Protein, Palmitoylated (or MAGUK p55 subfamily member) proteins
    cd00992
    Location:128 → 206
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02828
    Location:57 → 108
    L27; L27 domain
    cl27059
    Location:336 → 526
    Guanylate_kin; Guanylate kinase
Nucleotide Protein Strain
Heading Accession and Version

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