3KFV


Conserved Protein Domain Family
GuKc

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smart00072: GuKc 
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Guanylate kinase homologues.
Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities; instead at least some possess protein-binding functions.
Statistics
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PSSM-Id: 214504
Aligned: 31 rows
Threshold Bit Score: 123.557
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3KFV_A     115 TQRSREDLSALT-RQGRYpPYERVVLREASFKRPVVILGpvADIAXQKlTAEXPDQFEIAETV--SRTDS--P--SKIIK 187  human
O62683     577 tQRSREDLSALT-RQGhypPYERVVLREASFKRPVVILGpvADIAMQKlTAEMPDQFGIADSVl---rTDs---pSKIIK 649  dog
Q94880     602 reNWDDVVFSDS-ISKFP-AYERVVLRHPGFVRPVVLFGpvSDLARERlAKDFPDKFSTPLQDddKSAAT--SgkCRIVR 677  fruit fly
Q17549     479 EGVGCLKLRDRL-LESDRiTLACPVPYTSRTPKEGEFNG--VHYHFVS-KQKFHEDAKSGKFVefGEYQK--F--WYGTA 550  Caenorhabditis e...
CAA58067   383 QGVGRRSLKNKL-IMWDPdRYGTTVPYTSRRPKDSEREG--QGYSFVS-RGEMEADVRAGRYLehGEYEG--N--LYGTR 454  human
EAW51661   419 LGARLHELKQKV-VAENPqHFGVAVPHTTRPRKSHEKEG--VEYHFVS-KQAFEADLHHNKFLehGEYKE--N--LYGTS 490  human
CAI12103   693 QKVDCTALRPVL-ILG---PLLDVVKEMLVNEAPGKFCRcpLEVMKAS-QQAIERGVKDCLFVdyKRRSG--H--FDVTT 763  human
AAA02891   602 lRKSREDLSAQP-VQTKFpAYERVVLREAGFLRPVTIFGpiADVAREKlAREEPDIYQIAKSEprDAGTDqrS--SGYIR 678  human
NP_418518   12 SGSGKDSLLAEL-RLREQtQLLVAHRYITRDASAGSEN----HIAL-S-EQEFFTRAGQNLLAlsWHANG--L--YYGVG 80   Escherichia coli...
AAA61300   699 lRKSREDLTAVVsVSTKFpAYERVLLREAGFKRPVVLFGpiADIAMEKlANELPDWFQTAKTEpkDAGSEk-S--TGVVR 775  human
3KFV_A     188 LDTVRVIAEKDKHALLDVTPSAIERLNYVQYYPIVVFF-IPESRPALKALR----------Q---WLAPA-----SRRST 248  human
O62683     650 LDTVRVIAEKNKHALLDVTPSAVERLNYVQYYPIVVFCa-PESRAALKALR----------Q---WLAPA-----SRRSA 710  dog
Q94880     678 LSNIRDVMDRGKHALLDITPNAVDRLNYAQFYPVVIFLk-TDSKHVIKQLR----------H---GLPKA-----AHKSS 738  fruit fly
Q17549     551 KKDVVNVIERGKTCVMTLKAESLGAIRSPDIQPYIIFIaAPSLYILRRQREve-----------gTFGVK-----DDELK 614  Caenorhabditis e...
CAA58067   455 IDSIRGVVAAGKVCVLDVNPQAVKVLRTAEFVPYVVFIeAPDFETLRAMNRaalesgistkQ---LTEAD-----LRRTV 526  human
EAW51661   491 LEAIQAVMAKNKVCLVDVEPEALKQLRTSEFKPYIIFVkPAIQEKRKTPPM----------S---PACEDtaapfDEQQQ 557  human
CAI12103   764 VASIKEITEKNRHCLLDIAPHAIERLHHMHIYPIVIFIhYKSAKHIKEQRD----------PiylRDKVT-----QRHSK 828  human
AAA02891   679 LHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLn-PDSKQGVKTMR----------M---RLCPE-----SRKSA 739  human
NP_418518   81 VE-IDLWLHAGFDVLVNGSRAHLPQARARYQSALLPVClQVSPEILRQRLE----------N---RGREN-----ASEIN 141  Escherichia coli...
AAA61300   776 LNTVRQVIEQDKHALLDVTPKAVDLLNYTQWFSIVISF-TPDSRQGVNTMR----------Q---RLDPT-----SNNSS 836  human
3KFV_A     249 RRLyA-Q-AQKLRK-HsS-HLFTATIPLN-GTSD-TWyQELKAIIREQQ 291  human
O62683     711 RRL-Y-AqAQKLRK-H-SeHLFTATIPLR-GTSD-TWyQELKAVVREQQ 753  dog
Q94880     739 KKL-L-EqCQKLER-V-WsHIFSTQIALS-DEES-WY-RKLRDSIDLQQ 780  fruit fly
Q17549     615 AIL-T-Q-SKSIEQ-K-YgHLFDGIIVNI-DFEK-SF-RELKQILMKVN 655  Caenorhabditis elegans
CAA58067   527 EES-S-R-IQRGYG-H-Y---FDLCLVNS-NLER-TF-RELQTAMEKLR 564  human
EAW51661   558 EMA-A-S-AAFIDR-H-YgHLVDAVLVKE-DLQG-AY-SQLKVVLEKLs 598  human
CAI12103   829 EQF-E-A-AQKLEQ-E-YsRYFTGVIQGG-ALSS-IC-TQILAMVNQEQ 869  human
AAA02891   740 RKL-Y-ErSHKLAK-N-NhHLFTTTINLN-SMNDgWY-GALKEAVQQQQ 782  human
NP_418518  142 ARL-ArA-ARYTPQ-D-C-H----TLNNDgSLRQ-SV-DTLLTLIHQKE 179  Escherichia coli str. K12 substr. MG1655
AAA61300   837 RKL-FdH-ANKLKKtC-A-HLFTATINLN-SAND-SWfGSLKDTIQHQQ 879  human
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