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Alg2 ALG2, alpha-1,3/1,6-mannosyltransferase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38374, updated on 26-Apr-2024

Summary

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Official Symbol
Alg2provided by FlyBase
Official Full Name
ALG2, alpha-1,3/1,6-mannosyltransferaseprovided by FlyBase
Primary source
FLYBASE:FBgn0035401
Locus tag
Dmel_CG1291
See related
AllianceGenome:FB:FBgn0035401
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1291; dAlg2; Dmel\CG1291
Summary
Predicted to enable alpha-1,3-mannosyltransferase activity. Predicted to be involved in oligosaccharide-lipid intermediate biosynthetic process and protein glycosylation in endoplasmic reticulum. Located in endomembrane system. Is expressed in several structures, including adult head; embryonic/larval digestive system; and presumptive embryonic/larval digestive system. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ii and congenital myasthenic syndrome 14. Orthologous to human ALG2 (ALG2 alpha-1,3/1,6-mannosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
63B5-63B6; 3-6 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3143808..3145284)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3143808..3145284)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene prominin-like Neighboring gene transfer RNA:Methionine-CAT 2-1 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45819 Neighboring gene Ubiquitin specific protease 5 Neighboring gene BTB-protein-VII

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Diversity and functions of protein glycosylation in insects. Walski T, et al. Insect Biochem Mol Biol, 2017 Apr. PMID 28232040
  2. Protein correlation profiles identify lipid droplet proteins with high confidence. Krahmer N, et al. Mol Cell Proteomics, 2013 May. PMID 23319140, Free PMC Article
  3. The RNA-Binding ATPase, Armitage, Couples piRNA Amplification in Nuage to Phased piRNA Production on Mitochondria. Ge DT, et al. Mol Cell, 2019 Jun 6. PMID 31076285, Free PMC Article
  4. Genes and biological processes controlled by the Drosophila FOXA orthologue Fork head. Liu Y, et al. Insect Mol Biol, 2008 Apr. PMID 18353099
  5. A large-scale RNAi screen reveals that mitochondrial function is important for meiotic chromosome organization in oocytes. Nieken KJ, et al. Chromosoma, 2023 Mar. PMID 36648541, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables alpha-1,3-mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in oligosaccharide-lipid intermediate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endomembrane system HDA PubMed 

General protein information

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Preferred Names
ALG2, alpha-1,3/1,6-mannosyltransferase
Names
A-1,3/A-1,6-mannosyltransferase
Alg2-PA
CG1291-PA
NP_647772.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    3143808..3145284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139515.5 → NP_647772.1  ALG2, alpha-1,3/1,6-mannosyltransferase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647772.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95SA2, Q9VZU8
    Related
    FBpp0072887
    Conserved Domains (2) summary
    cd03805
    Location:2 → 404
    GT1_ALG2_like; This family is most closely related to the GT1 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2) ...
    COG0438
    Location:1 → 412
    RfaB; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95SA2 Q95SA2
Q9VZU8 Q9VZU8

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