U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Muc6 mucin 6, gastric [ Mus musculus (house mouse) ]

Gene ID: 353328, updated on 9-May-2024

Summary

Go to the top of the page Help
Official Symbol
Muc6provided by MGI
Official Full Name
mucin 6, gastricprovided by MGI
Primary source
MGI:MGI:2663233
See related
Ensembl:ENSMUSG00000118661 AllianceGenome:MGI:2663233
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be active in extracellular matrix and extracellular space. Is expressed in stomach. Orthologous to human MUC6 (mucin 6, oligomeric mucus/gel-forming). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum adult (RPKM 354.4), small intestine adult (RPKM 153.2) and 1 other tissue See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
7 F5; 7 87.03 cM
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141212404..141241659, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141633459..141655393, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene adaptor-related protein complex 2, alpha 2 subunit Neighboring gene predicted gene, 16982 Neighboring gene microRNA 7063 Neighboring gene mucin 2 Neighboring gene mucin 5, subtypes A and C, tracheobronchial/gastric

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. High-fat Diet Alters the Glycosylation Patterns of Duodenal Mucins in a Murine Model. Mastrodonato M, et al. J Histochem Cytochem, 2020 Apr. PMID 32141795, Free PMC Article
  2. Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity. Gavanescu I, et al. Proc Natl Acad Sci U S A, 2007 Mar 13. PMID 17360567, Free PMC Article
  3. The characterization of the first anti-mouse Muc6 antibody shows an increased expression of the mucin in pancreatic tissue of Cftr-knockout mice. Gouyer V, et al. Histochem Cell Biol, 2010 May. PMID 20309575
  4. The mouse secreted gel-forming mucin gene cluster. Escande F, et al. Biochim Biophys Acta, 2004 Feb 20. PMID 14984930
  5. Characterization of mouse muc6 and evidence of conservation of the gel-forming mucin gene cluster between human and mouse. Desseyn JL, et al. Genomics, 2003 Apr. PMID 12676567

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High-fat Diet Alters the Glycosylation Patterns of Duodenal Mucins in a Murine Model.
    Title: High-fat Diet Alters the Glycosylation Patterns of Duodenal Mucins in a Murine Model.
  2. Cftr-/- mice showed a higher expression of Muc6 at both protein and RNA levels compared with their control Cftr+/+ littermates, suggesting that Muc6 may contribute to blocking of pancreatic acini and ducts in mouse models of cystic fibrosis.
    Title: The characterization of the first anti-mouse Muc6 antibody shows an increased expression of the mucin in pancreatic tissue of Cftr-knockout mice.
  3. transcription of the Mucin 6 gene in thymic medullary epithelial cells is indeed Aire-dependent
    Title: Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity.
  4. organization of the secreted gel-forming mucin gene cluster and the complete gene structure of its different members
    Title: The mouse secreted gel-forming mucin gene cluster.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
mucin-6
Names
MUC-6
gastric mucin-6
gastric mucin-like protein
secreted gel-forming mucin-6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330001.2 → NP_001316930.1  mucin-6 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC102524, LXEJ02004842
    Consensus CDS
    CCDS90352.1
    UniProtKB/TrEMBL
    Q0VAV1, Q80Z18
    Conserved Domains (4) summary
    smart00215
    Location:360 → 404
    VWC_out; von Willebrand factor (vWF) type C domain
    pfam00094
    Location:869 → 1020
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:303 → 358
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:1058 → 1128
    C8; C8 domain

  2. NM_001368953.3 → NP_001355882.2  mucin-6 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC102524, LXEJ02004842
    UniProtKB/TrEMBL
    A0A7N9VSS4
    Related
    ENSMUSP00000159382.2, ENSMUST00000239500.1
    Conserved Domains (12) summary
    smart00041
    Location:4847 → 4926
    CT; C-terminal cystine knot-like domain (CTCK)
    smart00215
    Location:360 → 404
    VWC_out; von Willebrand factor (vWF) type C domain
    smart00216
    Location:387 → 550
    VWD; von Willebrand factor (vWF) type D domain
    smart00832
    Location:1057 → 1129
    C8; This domain contains 8 conserved cysteine residues
    PHA03247
    Location:4320 → 4742
    PHA03247; large tegument protein UL36; Provisional
    COG3889
    Location:3886 → 4052
    COG3889; Predicted periplasmic protein [Function unknown]
    COG5422
    Location:1406 → 1624
    ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
    pfam05109
    Location:2791 → 3187
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00094
    Location:869 → 1020
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:303 → 358
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:232 → 298
    C8; C8 domain
    cd19941
    Location:765 → 828
    TIL; trypsin inhibitor-like cysteine rich domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    141212404..141241659 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153192.1 → XP_036009085.1  mucin-6 isoform X8

    Conserved Domains (7) summary
    smart00041
    Location:2151 → 2230
    CT; C-terminal cystine knot-like domain (CTCK)
    smart00215
    Location:360 → 404
    VWC_out; von Willebrand factor (vWF) type C domain
    smart00832
    Location:1058 → 1130
    C8; This domain contains 8 conserved cysteine residues
    pfam05109
    Location:1652 → 2041
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00094
    Location:869 → 1021
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:303 → 358
    TIL; Trypsin Inhibitor like cysteine rich domain
    cd19941
    Location:765 → 828
    TIL; trypsin inhibitor-like cysteine rich domain

  2. XM_036153186.1 → XP_036009079.1  mucin-6 isoform X2

    UniProtKB/TrEMBL
    A0A7N9VSS4
    Conserved Domains (13) summary
    smart00041
    Location:4233 → 4312
    CT; C-terminal cystine knot-like domain (CTCK)
    smart00215
    Location:360 → 404
    VWC_out; von Willebrand factor (vWF) type C domain
    smart00216
    Location:387 → 550
    VWD; von Willebrand factor (vWF) type D domain
    smart00832
    Location:1058 → 1130
    C8; This domain contains 8 conserved cysteine residues
    PHA03247
    Location:3706 → 4128
    PHA03247; large tegument protein UL36; Provisional
    COG3889
    Location:3272 → 3438
    COG3889; Predicted periplasmic protein [Function unknown]
    COG5422
    Location:1407 → 1625
    ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
    pfam05109
    Location:2177 → 2573
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl17735
    Location:830 → 887
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:869 → 1021
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:303 → 358
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:232 → 298
    C8; C8 domain
    cd19941
    Location:765 → 828
    TIL; trypsin inhibitor-like cysteine rich domain

  3. XM_036153188.1 → XP_036009081.1  mucin-6 isoform X4

    UniProtKB/TrEMBL
    A0A7N9VSS4
    Conserved Domains (13) summary
    smart00041
    Location:4164 → 4243
    CT; C-terminal cystine knot-like domain (CTCK)
    smart00215
    Location:360 → 404
    VWC_out; von Willebrand factor (vWF) type C domain
    smart00216
    Location:387 → 550
    VWD; von Willebrand factor (vWF) type D domain
    smart00832
    Location:1058 → 1130
    C8; This domain contains 8 conserved cysteine residues
    PHA03247
    Location:3637 → 4059
    PHA03247; large tegument protein UL36; Provisional
    COG3889
    Location:3203 → 3369
    COG3889; Predicted periplasmic protein [Function unknown]
    COG5422
    Location:1407 → 1625
    ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
    pfam05109
    Location:1727 → 2176
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl17735
    Location:830 → 887
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:869 → 1021
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:303 → 358
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:232 → 298
    C8; C8 domain
    cd19941
    Location:765 → 828
    TIL; trypsin inhibitor-like cysteine rich domain

  4. XM_036153187.1 → XP_036009080.1  mucin-6 isoform X3

    UniProtKB/TrEMBL
    A0A7N9VSS4
    Conserved Domains (12) summary
    smart00041
    Location:4233 → 4312
    CT; C-terminal cystine knot-like domain (CTCK)
    smart00215
    Location:360 → 404
    VWC_out; von Willebrand factor (vWF) type C domain
    smart00216
    Location:387 → 550
    VWD; von Willebrand factor (vWF) type D domain
    smart00832
    Location:1058 → 1130
    C8; This domain contains 8 conserved cysteine residues
    PHA03247
    Location:3706 → 4128
    PHA03247; large tegument protein UL36; Provisional
    COG5422
    Location:1407 → 1625
    ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
    pfam05109
    Location:1727 → 2176
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl17735
    Location:830 → 887
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:869 → 1021
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:303 → 358
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:232 → 298
    C8; C8 domain
    cd19941
    Location:765 → 828
    TIL; trypsin inhibitor-like cysteine rich domain

  5. XM_036153189.1 → XP_036009082.1  mucin-6 isoform X5

    UniProtKB/TrEMBL
    A0A7N9VSS4
    Conserved Domains (12) summary
    smart00041
    Location:4164 → 4243
    CT; C-terminal cystine knot-like domain (CTCK)
    smart00215
    Location:360 → 404
    VWC_out; von Willebrand factor (vWF) type C domain
    smart00216
    Location:387 → 550
    VWD; von Willebrand factor (vWF) type D domain
    smart00832
    Location:1058 → 1130
    C8; This domain contains 8 conserved cysteine residues
    PHA03247
    Location:3637 → 4059
    PHA03247; large tegument protein UL36; Provisional
    COG5422
    Location:1407 → 1625
    ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
    pfam05109
    Location:1727 → 2176
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl17735
    Location:830 → 887
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:869 → 1021
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:303 → 358
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:232 → 298
    C8; C8 domain
    cd19941
    Location:765 → 828
    TIL; trypsin inhibitor-like cysteine rich domain

  6. XM_036153185.1 → XP_036009078.1  mucin-6 isoform X1

    UniProtKB/TrEMBL
    A0A7N9VSS4
    Conserved Domains (13) summary
    smart00041
    Location:4506 → 4585
    CT; C-terminal cystine knot-like domain (CTCK)
    smart00215
    Location:360 → 404
    VWC_out; von Willebrand factor (vWF) type C domain
    smart00216
    Location:387 → 550
    VWD; von Willebrand factor (vWF) type D domain
    smart00832
    Location:1058 → 1130
    C8; This domain contains 8 conserved cysteine residues
    PHA03247
    Location:3979 → 4401
    PHA03247; large tegument protein UL36; Provisional
    COG3889
    Location:3545 → 3711
    COG3889; Predicted periplasmic protein [Function unknown]
    COG5422
    Location:1407 → 1625
    ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
    pfam05109
    Location:1727 → 2176
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl17735
    Location:830 → 887
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:869 → 1021
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:303 → 358
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:232 → 298
    C8; C8 domain
    cd19941
    Location:765 → 828
    TIL; trypsin inhibitor-like cysteine rich domain

  7. XM_036153191.1 → XP_036009084.1  mucin-6 isoform X7

    UniProtKB/Swiss-Prot
    Q80T03, Q80Z22
    Conserved Domains (7) summary
    smart00041
    Location:2220 → 2299
    CT; C-terminal cystine knot-like domain (CTCK)
    smart00215
    Location:360 → 404
    VWC_out; von Willebrand factor (vWF) type C domain
    smart00832
    Location:1058 → 1130
    C8; This domain contains 8 conserved cysteine residues
    pfam05109
    Location:1464 → 1901
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00094
    Location:869 → 1021
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:303 → 358
    TIL; Trypsin Inhibitor like cysteine rich domain
    cd19941
    Location:765 → 828
    TIL; trypsin inhibitor-like cysteine rich domain

  8. XM_036153190.1 → XP_036009083.1  mucin-6 isoform X6

    Conserved Domains (3) summary
    smart00041
    Location:3327 → 3406
    CT; C-terminal cystine knot-like domain (CTCK)
    PHA03247
    Location:2789 → 3222
    PHA03247; large tegument protein UL36; Provisional
    TIGR00927
    Location:1162 → 1511
    2A1904; K+-dependent Na+/Ca+ exchanger

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_181729.3: Suppressed sequence

    Description
    NM_181729.3: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80T03.1 GenPept UniProtKB/Swiss-Prot:Q80T03

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous