arpc1b actin related protein 2/3 complex, subunit 1B [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: arpc1bprovided by ZNC
Official Full Name: actin related protein 2/3 complex, subunit 1Bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7414
See related: Ensembl:ENSDARG00000027063 AllianceGenome:ZFIN:ZDB-GENE-030131-7414
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb871; arpc1a; fj15h02; zgc:64056; wu:fj08e12; wu:fj15h02
Summary: Predicted to enable actin filament binding activity. Acts upstream of or within T cell differentiation and thrombocyte differentiation. Predicted to be located in actin cytoskeleton; cytoplasm; and nucleus. Predicted to be part of Arp2/3 protein complex. Is expressed in blood; blood island; pectoral fin musculature; pharyngeal arch 3-7 skeleton; and ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in gastritis; immunodeficiency 71; and myelodysplastic syndrome. Orthologous to human ARPC1B (actin related protein 2/3 complex subunit 1B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (40809048..40820479)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (40667190..40678621)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb09e12.x1 (e-PCR)
- UniSTS:189985

fj08e12.x1 (e-PCR)
- UniSTS:198465

AW184554 (e-PCR)
- UniSTS:205754

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Arp2/3 complex-mediated actin nucleation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thrombocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Arp2/3 protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Arp2/3 protein complex	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: actin-related protein 2/3 complex subunit 1B

Names: actin related protein 2/3 complex, subunit 1A, 41kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213156.1 → NP_998321.1 actin-related protein 2/3 complex subunit 1B

See identical proteins and their annotated locations for NP_998321.1

Status: PROVISIONAL

Source sequence(s)

BC053229

UniProtKB/TrEMBL

B2GPS5, Q7T372

Related

ENSDARP00000038520.4, ENSDART00000033713.5

Conserved Domains (3) summary

COG2319
Location:2 → 360

WD40; WD40 repeat [General function prediction only]

sd00039
Location:11 → 50

7WD40; WD40 repeat [structural motif]

cl02567
Location:45 → 273

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...