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Conserved domains on  [gi|47085927|ref|NP_998321|]
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actin-related protein 2/3 complex subunit 1B [Danio rerio]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
15-264 1.83e-20

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.90  E-value: 1.83e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085927  15 AWNKDRTQIALCPNNHEVHIYNKAgnNWNKIHVLKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLkgDAWKPTLVILR 94
Cdd:COG2319 127 AFSPDGKTLASGSADGTVRLWDLA--TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL--ATGKLLRTLTG 202

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085927  95 INRAARCVKWSPKENKFAVGSGSRLISVcyfeqdndWWV----CKHIKKPIRSTILCLDWHPNNVLLAAGSCDFKCRIFS 170
Cdd:COG2319 203 HTGAVRSVAFSPDGKLLASGSADGTVRL--------WDLatgkLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085927 171 AyikeveekpaPTawgskmpfGEVMFESTGTSGWVHGVCFSDSGNRVAWASHDSTVAVAEGGKTAVCTSLTSETLPLLCV 250
Cdd:COG2319 275 L----------AT--------GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                       250
                ....*....|....
gi 47085927 251 TFITENSLVAAGHD 264
Cdd:COG2319 337 AFSPDGKTLASGSD 350
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
15-264 1.83e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.90  E-value: 1.83e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085927  15 AWNKDRTQIALCPNNHEVHIYNKAgnNWNKIHVLKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLkgDAWKPTLVILR 94
Cdd:COG2319 127 AFSPDGKTLASGSADGTVRLWDLA--TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL--ATGKLLRTLTG 202

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085927  95 INRAARCVKWSPKENKFAVGSGSRLISVcyfeqdndWWV----CKHIKKPIRSTILCLDWHPNNVLLAAGSCDFKCRIFS 170
Cdd:COG2319 203 HTGAVRSVAFSPDGKLLASGSADGTVRL--------WDLatgkLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085927 171 AyikeveekpaPTawgskmpfGEVMFESTGTSGWVHGVCFSDSGNRVAWASHDSTVAVAEGGKTAVCTSLTSETLPLLCV 250
Cdd:COG2319 275 L----------AT--------GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                       250
                ....*....|....
gi 47085927 251 TFITENSLVAAGHD 264
Cdd:COG2319 337 AFSPDGKTLASGSD 350
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-273 6.84e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.85  E-value: 6.84e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085927  45 IHVLKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGDAWKPTLVILRInrAARCVKWSPKENKFAVGSGSRLISVcy 124
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG--PVRDVAASADGTYLASGSSDKTIRL-- 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085927 125 feqdndWWV----CKHIKKPIRSTILCLDWHPNNVLLAAGSCDFKCRIFSayikeveekpaptawgskMPFGEVMFESTG 200
Cdd:cd00200  78 ------WDLetgeCVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD------------------VETGKCLTTLRG 133

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47085927 201 TSGWVHGVCFSDSGNRVAWASHDSTVAVAEGGKTAVCTSLTSETLPLLCVTFI-TENSLVAAGHDCypVLFVYD 273
Cdd:cd00200 134 HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSpDGEKLLSSSSDG--TIKLWD 205
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 41-79 2.05e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 2.05e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 47085927     41 NWNKIHVLKEHNGQVTGIDWAPESNRIVTCGTDRNAYVW 79
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
42-79 3.69e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 3.69e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 47085927    42 WNKIHVLKEHNGQVTGIDWAPESNRIVTCGTDRNAYVW 79
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PRK08861 PRK08861
O-succinylhomoserine (thiol)-lyase;
223-279 4.50e-03

O-succinylhomoserine (thiol)-lyase;


Pssm-ID: 181567 [Multi-domain]  Cd Length: 388  Bit Score: 38.72  E-value: 4.50e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47085927  223 DSTVAVAEGGKTAVCTSLTSETLPLLCVTFITENSLVAAGHDCY----------------PVLFVYDSNNAAL 279
Cdd:PRK08861  59 EQTLSELESGKGAVVTNCGTSALNLWVSALLGPDDLIVAPHDCYggtyrlfntrankgdfKVQFVDQSDAAAL 131
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
15-264 1.83e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.90  E-value: 1.83e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085927  15 AWNKDRTQIALCPNNHEVHIYNKAgnNWNKIHVLKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLkgDAWKPTLVILR 94
Cdd:COG2319 127 AFSPDGKTLASGSADGTVRLWDLA--TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL--ATGKLLRTLTG 202

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085927  95 INRAARCVKWSPKENKFAVGSGSRLISVcyfeqdndWWV----CKHIKKPIRSTILCLDWHPNNVLLAAGSCDFKCRIFS 170
Cdd:COG2319 203 HTGAVRSVAFSPDGKLLASGSADGTVRL--------WDLatgkLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085927 171 AyikeveekpaPTawgskmpfGEVMFESTGTSGWVHGVCFSDSGNRVAWASHDSTVAVAEGGKTAVCTSLTSETLPLLCV 250
Cdd:COG2319 275 L----------AT--------GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                       250
                ....*....|....
gi 47085927 251 TFITENSLVAAGHD 264
Cdd:COG2319 337 AFSPDGKTLASGSD 350
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-273 6.84e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.85  E-value: 6.84e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085927  45 IHVLKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGDAWKPTLVILRInrAARCVKWSPKENKFAVGSGSRLISVcy 124
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG--PVRDVAASADGTYLASGSSDKTIRL-- 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085927 125 feqdndWWV----CKHIKKPIRSTILCLDWHPNNVLLAAGSCDFKCRIFSayikeveekpaptawgskMPFGEVMFESTG 200
Cdd:cd00200  78 ------WDLetgeCVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD------------------VETGKCLTTLRG 133

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47085927 201 TSGWVHGVCFSDSGNRVAWASHDSTVAVAEGGKTAVCTSLTSETLPLLCVTFI-TENSLVAAGHDCypVLFVYD 273
Cdd:cd00200 134 HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSpDGEKLLSSSSDG--TIKLWD 205
WD40 COG2319
WD40 repeat [General function prediction only];
15-262 1.49e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.12  E-value: 1.49e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085927  15 AWNKDRTQIALCPNNHEVHIYNKAgnNWNKIHVLKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGDAWKPTLVilR 94
Cdd:COG2319 169 AFSPDGKLLASGSDDGTVRLWDLA--TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT--G 244

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085927  95 INRAARCVKWSPKENKFAVGSGSRLISVCyfeqDNDWWVCKHIKKPIRSTILCLDWHPNNVLLAAGSCDFKCRIFSAyik 174
Cdd:COG2319 245 HSGSVRSVAFSPDGRLLASGSADGTVRLW----DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL--- 317

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085927 175 eveekpaptawgskmPFGEVMFESTGTSGWVHGVCFSDSGNRVAWASHDSTVAVAEGGKTAVCTSLTSETLPLLCVTFIT 254
Cdd:COG2319 318 ---------------ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382


                ....*...
gi 47085927 255 ENSLVAAG 262
Cdd:COG2319 383 DGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
15-228 2.77e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.65  E-value: 2.77e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085927  15 AWNKDRTQIALCPNNHEVHIYNKAGNNWnkIHVLKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGDAWKPTLVilR 94
Cdd:COG2319 211 AFSPDGKLLASGSADGTVRLWDLATGKL--LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT--G 286

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085927  95 INRAARCVKWSPKENKFAVGSGSRLISVcyfeqdndWWV----CKHIKKPIRSTILCLDWHPNNVLLAAGSCDFKCRIFS 170
Cdd:COG2319 287 HSGGVNSVAFSPDGKLLASGSDDGTVRL--------WDLatgkLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 47085927 171 AyikeveekpaptawgskmPFGEVMFESTGTSGWVHGVCFSDSGNRVAWASHDSTVAV 228
Cdd:COG2319 359 L------------------ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-228 8.77e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.69  E-value: 8.77e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085927   9 EPISCHAWNKDRTQIALCPNNHEVHIYNkaGNNWNKIHVLKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKgdAWKP 88
Cdd:cd00200  94 SYVSSVAFSPDGRILSSSSRDKTIKVWD--VETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR--TGKC 169

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085927  89 TLVILRINRAARCVKWSPKENKFAVGSGSRLISVcyFEQDNDWWVCKHIKKpiRSTILCLDWHPNNVLLAAGSCDFKCRI 168
Cdd:cd00200 170 VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKL--WDLSTGKCLGTLRGH--ENGVNSVAFSPDGYLLASGSEDGTIRV 245

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085927 169 fsayikeveekpaptaWGSKMpfGEVMFESTGTSGWVHGVCFSDSGNRVAWASHDSTVAV 228
Cdd:cd00200 246 ----------------WDLRT--GECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
15-264 6.52e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.33  E-value: 6.52e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085927  15 AWNKDRTQIALCPNNHEVHIYNKAGNNWnkIHVLKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLkgDAWKPTLVILR 94
Cdd:COG2319  85 AFSPDGRLLASASADGTVRLWDLATGLL--LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL--ATGKLLRTLTG 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085927  95 INRAARCVKWSPKENKFAVGSGSRLISVcyfeqdndWWV----CKHIKKPIRSTILCLDWHPNNVLLAAGSCDFKCRIFS 170
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGTVRL--------WDLatgkLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD 232

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085927 171 ayikeveekpAPTawgskmpfGEVMFESTGTSGWVHGVCFSDSGNRVAWASHDSTVAV--AEGGKTAvcTSLTSETLPLL 248
Cdd:COG2319 233 ----------LAT--------GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLwdLATGELL--RTLTGHSGGVN 292

                       250
                ....*....|....*.
gi 47085927 249 CVTFITENSLVAAGHD 264
Cdd:COG2319 293 SVAFSPDGKLLASGSD 308
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-265 7.81e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.21  E-value: 7.81e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085927  10 PISCHAWNKDRTQIALCPNNHEVHIYNKAGNNwnKIHVLKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGDawKPT 89
Cdd:cd00200  53 PVRDVAASADGTYLASGSSDKTIRLWDLETGE--CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG--KCL 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085927  90 LVILRINRAARCVKWSPkENKFAVGSGS-RLISVCyfeqDNDWWVCKHIKKPIRSTILCLDWHPNNVLLAAGSCDFKCRI 168
Cdd:cd00200 129 TTLRGHTDWVNSVAFSP-DGTFVASSSQdGTIKLW----DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKL 203

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085927 169 FSayikeveekpaptawgskMPFGEVMFESTGTSGWVHGVCFSDSGNRVAWASHDSTVAVAEGGKTAVCTSLTSETLPLL 248
Cdd:cd00200 204 WD------------------LSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVT 265

                       250
                ....*....|....*...
gi 47085927 249 CVTFITENS-LVAAGHDC 265
Cdd:cd00200 266 SLAWSPDGKrLASGSADG 283
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 41-79 2.05e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 2.05e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 47085927     41 NWNKIHVLKEHNGQVTGIDWAPESNRIVTCGTDRNAYVW 79
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
42-79 3.69e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 3.69e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 47085927    42 WNKIHVLKEHNGQVTGIDWAPESNRIVTCGTDRNAYVW 79
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 COG2319
WD40 repeat [General function prediction only];
15-83 1.01e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.13  E-value: 1.01e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47085927  15 AWNKDRTQIALCPNNHEVHIYNKAGnnWNKIHVLKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKG 83
Cdd:COG2319 337 AFSPDGKTLASGSDDGTVRLWDLAT--GELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
59-264 1.78e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.36  E-value: 1.78e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085927  59 DWAPESNRIVTCGTDRNAYVWTLKGDAWKPTLVILRinRAARCVKWSPKENKFAVGSGSRLISVcyfeQDNDWWVCKHIK 138
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLA--AAVASLAASPDGARLAAGAGDLTLLL----LDAAAGALLATL 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085927 139 KPIRSTILCLDWHPNNVLLAAGSCDFKCRIFSAyikeveekpaptawgskmPFGEVMFESTGTSGWVHGVCFSDSGNRVA 218
Cdd:COG2319  75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWDL------------------ATGLLLRTLTGHTGAVRSVAFSPDGKTLA 136

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 47085927 219 WASHDSTVAV--AEGGKTAvcTSLTSETLPLLCVTFITENSLVAAGHD 264
Cdd:COG2319 137 SGSADGTVRLwdLATGKLL--RTLTGHSGAVTSVAFSPDGKLLASGSD 182
PRK08861 PRK08861
O-succinylhomoserine (thiol)-lyase;
223-279 4.50e-03

O-succinylhomoserine (thiol)-lyase;


Pssm-ID: 181567 [Multi-domain]  Cd Length: 388  Bit Score: 38.72  E-value: 4.50e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47085927  223 DSTVAVAEGGKTAVCTSLTSETLPLLCVTFITENSLVAAGHDCY----------------PVLFVYDSNNAAL 279
Cdd:PRK08861  59 EQTLSELESGKGAVVTNCGTSALNLWVSALLGPDDLIVAPHDCYggtyrlfntrankgdfKVQFVDQSDAAAL 131
PRK08045 PRK08045
cystathionine gamma-synthase; Provisional
 226-279 5.45e-03

cystathionine gamma-synthase; Provisional


Pssm-ID: 169194 [Multi-domain]  Cd Length: 386  Bit Score: 38.34  E-value: 5.45e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085927  226 VAVAEGGKTAVCTSLTSETLPLLCVTFITENSLVAAGHDCY----------------PVLFVYDSNNAAL 279
Cdd:PRK08045  61 LAELEGGAGAVLTNTGMSAIHLVTTVFLKPGDLLVAPHDCYggsyrlfdslakrgcyRVLFVDQGDEQAL 130
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 192-228 8.32e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 8.32e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 47085927    192 GEVMFESTGTSGWVHGVCFSDSGNRVAWASHDSTVAV 228
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKL 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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