ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: ADAMTS5provided by VGNC
Official Full Name: ADAM metallopeptidase with thrombospondin type 1 motif 5provided by VGNC
Primary source: VGNC:VGNC:50085
See related: BGD:BT21940; Ensembl:ENSBTAG00000000648
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	1	NC_037328.1 (9441018..9491324)

Chromosome 1 - NC_037328.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:: NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The delayed activation of proMMPs and the relatively low cleavage efficiency of MMPs compared to ADAMTS5 (aggrecanase) explains the minor contribution of the MMP enzymes to aggrecan catabolism in vivo.
Title: MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein.
Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production.
Title: Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production.
identified multiple conserved amino acids within regions N- and C-terminal to the site of scission that may influence enzyme-substrate recognition, and may interact with exosites on ADAMTS-4 and ADAMTS-5
Title: Conserved sequence in the aggrecan interglobular domain modulates cleavage by ADAMTS-4 and ADAMTS-5.
ADAMTS4 and ADAMTS5 are inhibited by alpha2-macroglobulin
Title: Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: A disintegrin and metalloproteinase with thrombospondin motifs 5

Names: ADAM-TS 5; ADAM-TS5; ADAMTS-5; ADMP-2; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5; aggrecanase-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166515.1 → NP_001159987.1 A disintegrin and metalloproteinase with thrombospondin motifs 5 precursor

See identical proteins and their annotated locations for NP_001159987.1

Status: PROVISIONAL

Source sequence(s)

NKLS02000001

UniProtKB/TrEMBL

F1MRZ2

Related

ENSBTAP00000000849.3, ENSBTAT00000000849.5

Conserved Domains (5) summary

smart00209
Location:574 → 626

TSP1; Thrombospondin type 1 repeats

cd04273
Location:273 → 477

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01421
Location:273 → 480

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:70 → 181

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:736 → 856

ADAM_spacer1; ADAM-TS Spacer 1

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

Range

9441018..9491324

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024993812.2 → XP_024849580.1 A disintegrin and metalloproteinase with thrombospondin motifs 5 isoform X1

Conserved Domains (3) summary

smart00209
Location:574 → 626

TSP1; Thrombospondin type 1 repeats

cd04273
Location:273 → 477

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01562
Location:91 → 170

Pep_M12B_propep; Reprolysin family propeptide