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ADAM2 ADAM metallopeptidase domain 2 [ Bos taurus (cattle) ]

Gene ID: 281599, updated on 16-Jan-2024

Summary

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Official Symbol
ADAM2provided by VGNC
Official Full Name
ADAM metallopeptidase domain 2provided by VGNC
Primary source
VGNC:VGNC:55029
See related
BGD:BT30422; Ensembl:ENSBTAG00000009408
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
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Genomic context

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Location:
chromosome: 27
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 27 NC_037354.1 (34592557..34693901, complement)

Chromosome 27 - NC_037354.1Genomic Context describing neighboring genes Neighboring gene disintegrin and metalloproteinase domain-containing protein 5-like Neighboring gene vasculin-like protein 1 Neighboring gene replication protein A 32 kDa subunit-like Neighboring gene ADAM metallopeptidase domain 3A (cyritestin 1) Neighboring gene ADAM metallopeptidase domain 18 Neighboring gene S-phase kinase-associated protein 1-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037354.1 Chromosome 27 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Biochemical and molecular characterization of bovine fertilin alpha and beta (ADAM 1 and ADAM 2): a candidate sperm-egg binding/fusion complex. Waters SI, et al. Biol Reprod, 1997 May. PMID 9160725
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in binding of sperm to zona pellucida IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
disintegrin and metalloproteinase domain-containing protein 2
Names
ADAM 2
ADAM metallopeptidase domain 2 (fertilin beta)
PH-30
PH30
PH30-beta
a disintegrin and metalloproteinase domain 2 (fertilin beta)
fertilin subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174228.1 → NP_776653.1  disintegrin and metalloproteinase domain-containing protein 2 precursor

    See identical proteins and their annotated locations for NP_776653.1

    Status: PROVISIONAL

    Source sequence(s)
    AF086808
    UniProtKB/Swiss-Prot
    O77780
    Related
    ENSBTAP00000012384.6, ENSBTAT00000012384.6
    Conserved Domains (5) summary
    smart00608
    Location:471 → 608
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:178 → 373
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:392 → 468
    Disintegrin; Disintegrin
    pfam01421
    Location:178 → 375
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:34 → 140
    Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037354.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    34592557..34693901 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024986188.2 → XP_024841956.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X1

    Conserved Domains (4) summary
    smart00050
    Location:392 → 469
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:471 → 608
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:178 → 375
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:34 → 141
    Pep_M12B_propep; Reprolysin family propeptide

  2. XM_024986190.2 → XP_024841958.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X3

    Conserved Domains (4) summary
    smart00050
    Location:288 → 365
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:367 → 504
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:74 → 271
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:1 → 37
    Pep_M12B_propep; Reprolysin family propeptide

  3. XM_024986189.2 → XP_024841957.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    G1K1H0
    Conserved Domains (4) summary
    smart00050
    Location:392 → 469
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:471 → 608
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:178 → 375
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:34 → 141
    Pep_M12B_propep; Reprolysin family propeptide
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O77780.1 GenPept UniProtKB/Swiss-Prot:O77780

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