Adam1a a disintegrin and metallopeptidase domain 1a [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adam1aprovided by MGI
Official Full Name: a disintegrin and metallopeptidase domain 1aprovided by MGI
Primary source: MGI:MGI:2429504
See related: Ensembl:ENSMUSG00000072647 AllianceGenome:MGI:2429504
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ftna; Adam1
Summary: Predicted to enable metal ion binding activity and metalloendopeptidase activity. Acts upstream of or within binding activity of sperm to zona pellucida. Located in membrane raft. Orthologous to human ADAM1A (ADAM metallopeptidase domain 1A (pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 5 F; 5 61.84 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (121656667..121659758, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (121518604..121521695, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Localization of ADAM1a in the endoplasmic reticulum of testicular germ cells and on the surface of epididymal sperm.
Title: Differential localization of ADAM1a and ADAM1b in the endoplasmic reticulum of testicular germ cells and on the surface of epididymal sperm.
ADAM1a/ADAM2 Fertilin complex has roles in expression of ADAM3 on the cell surface of mouse sperm
Title: Possible function of the ADAM1a/ADAM2 Fertilin complex in the appearance of ADAM3 on the sperm surface.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Markers

U22056 (e-PCR)
- UniSTS:125697

AW050088 (e-PCR)
- UniSTS:179254

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	NAS Non-traceable Author Statement more info	PubMed
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in binding of sperm to zona pellucida	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within binding of sperm to zona pellucida	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fusion of sperm to egg plasma membrane involved in single fertilization	NAS Non-traceable Author Statement more info	PubMed
involved_in male gonad development	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in sperm head plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: disintegrin and metalloproteinase domain-containing protein 1a

Names: ADAM 1a; PH-30 alpha; a disintegrin and metalloproteinase domain 1a (fertilin alpha); fertilin alpha; fertilin subunit alpha-a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172126.2 → NP_742124.2 disintegrin and metalloproteinase domain-containing protein 1a precursor

See identical proteins and their annotated locations for NP_742124.2

Status: PROVISIONAL

Source sequence(s)

BC052093

Consensus CDS

CCDS19637.1

UniProtKB/Swiss-Prot

Q60617, Q60813, Q80WR7, Q8R533

UniProtKB/TrEMBL

Q3V0B1, Q3V0H1

Related

ENSMUSP00000098320.5, ENSMUST00000100757.6

Conserved Domains (5) summary

smart00050
Location:447 → 519

DISIN; Homologues of snake disintegrins

smart00608
Location:521 → 657

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:235 → 427

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam01421
Location:235 → 429

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:95 → 190

Pep_M12B_propep; Reprolysin family propeptide