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Vcpkmt valosin containing protein lysine (K) methyltransferase [ Mus musculus (house mouse) ]

Gene ID: 207965, updated on 2-May-2024

Summary

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Official Symbol
Vcpkmtprovided by MGI
Official Full Name
valosin containing protein lysine (K) methyltransferaseprovided by MGI
Primary source
MGI:MGI:2684917
See related
Ensembl:ENSMUSG00000049882 AllianceGenome:MGI:2684917
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm71; VCP-KMT; Mettl21d; Mettl221d
Summary
Predicted to enable ATPase binding activity and protein-lysine N-methyltransferase activity. Predicted to be involved in negative regulation of ATPase activity and peptidyl-lysine trimethylation. Predicted to act upstream of or within methylation. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Orthologous to human VCPKMT (valosin containing protein lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 4.9), cerebellum adult (RPKM 4.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 C2; 12 28.92 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (69623504..69629883, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (69576735..69583017, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31512 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:70602988-70603097 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:70617614-70617767 Neighboring gene predicted gene, 46353 Neighboring gene STARR-positive B cell enhancer ABC_E7141 Neighboring gene STARR-seq mESC enhancer starr_32372 Neighboring gene predicted gene, 24449 Neighboring gene SOS Ras/Rho guanine nucleotide exchange factor 2 Neighboring gene predicted gene, 31679

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice. Fusser M, et al. PLoS One, 2015. PMID 26544960, Free PMC Article
  2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice
    Title: Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein-lysine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-lysine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of ATP-dependent activity ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-lysine methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-lysine trimethylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-lysine trimethylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-lysine trimethylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein N-lysine methyltransferase METTL21D
Names
VCP lysine methyltransferase
methyltransferase like 21D
methyltransferase-like protein 21D
protein-lysine methyltransferase METTL21D
valosin-containing protein lysine methyltransferase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033236.3 → NP_001028408.2  protein N-lysine methyltransferase METTL21D isoform 2

    See identical proteins and their annotated locations for NP_001028408.2

    Status: VALIDATED

    Source sequence(s)
    AC153658
    Consensus CDS
    CCDS36464.1
    UniProtKB/Swiss-Prot
    B2RSP0, Q3UML0, Q8C436
    Related
    ENSMUSP00000055002.10, ENSMUST00000058639.11
    Conserved Domains (1) summary
    pfam10294
    Location:22 → 194
    Methyltransf_16; Lysine methyltransferase

  2. NM_001379044.1 → NP_001365973.1  protein N-lysine methyltransferase METTL21D isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC153658
    Conserved Domains (1) summary
    pfam10294
    Location:22 → 194
    Methyltransf_16; Lysine methyltransferase

RNA

  1. NR_166433.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153658

  2. NR_166434.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153658

  3. NR_166435.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153658

  4. NR_166437.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153658

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    69623504..69629883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157295.1 → XP_036013188.1  protein N-lysine methyltransferase METTL21D isoform X1

    Conserved Domains (1) summary
    pfam10294
    Location:54 → 226
    Methyltransf_16; Lysine methyltransferase

RNA

  1. XR_004937479.1 RNA Sequence

    Related
    ENSMUST00000238220.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C436.2 GenPept UniProtKB/Swiss-Prot:Q8C436

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