Sema3e sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sema3eprovided by MGI
Official Full Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Eprovided by MGI
Primary source: MGI:MGI:1340034
See related: Ensembl:ENSMUSG00000063531 AllianceGenome:MGI:1340034
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Semah; mKIAA0331; 6430702L12
Summary: Enables semaphorin receptor binding activity. Involved in several processes, including angiogenesis; negative regulation of angiogenesis; and regulation of actin cytoskeleton reorganization. Located in extracellular space. Is expressed in several structures, including hemolymphoid system gland; nervous system; nose; palatal shelf mesenchyme; and trunk mesenchyme. Human ortholog(s) of this gene implicated in CHARGE syndrome. Orthologous to human SEMA3E (semaphorin 3E). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in lung adult (RPKM 7.6), placenta adult (RPKM 3.8) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 A1; 5 5.66 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (14075290..14306703)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (14025276..14256689)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Vascular Sema3E-Plexin-D1 Signaling Reactivation Promotes Post-stroke Recovery through VEGF Downregulation in Mice.
Title: Vascular Sema3E-Plexin-D1 Signaling Reactivation Promotes Post-stroke Recovery through VEGF Downregulation in Mice.
CRMP4-mediated fornix development involves Semaphorin-3E signaling pathway.
Title: CRMP4-mediated fornix development involves Semaphorin-3E signaling pathway.
Semaphorin 3E deficiency dysregulates dendritic cell functions: In vitro and in vivo evidence.
Title: Semaphorin 3E deficiency dysregulates dendritic cell functions: In vitro and in vivo evidence.
Semaphorin 3E Promotes Susceptibility to Leishmania major Infection in Mice by Suppressing CD4(+) Th1 Cell Response.
Title: Semaphorin 3E Promotes Susceptibility to Leishmania major Infection in Mice by Suppressing CD4(+) Th1 Cell Response.
Semaphorin 3E Protects against Chlamydial Infection by Modulating Dendritic Cell Functions.
Title: Semaphorin 3E Protects against Chlamydial Infection by Modulating Dendritic Cell Functions.
data show that Sema3E plays an essential role in dampening the early inflammatory response to LPS by regulating macrophage function, suggesting an essential role of this pathway in macrophage inflammatory response
Title: Semaphorin 3E Regulates the Response of Macrophages to Lipopolysaccharide-Induced Systemic Inflammation.
SEMA3E deficiency could be a predisposing factor that makes airway smooth muscle cells prone to a hypercontractile phenotype and leading to heightened airway narrowing and hyperresponsiveness.
Title: Genetic Deletion of Semaphorin 3E Aggravates Airway Contraction in a Mouse Model of Allergic Asthma.
Our current work revealed a novel role of Sema-3E in limiting NK-cell migrations toward immature DC in NK-DC crosstalk.
Title: Semaphorin-3E Produced by Immature Dendritic Cells Regulates Activated Natural Killer Cells Migration.
Results describe new roles of Sema3E/PlexinD1 signaling during development and in adult hippocampal formation and provide evidence for an implication of Sema3E/PlexinD1 in the layer-specific development of the entorhino-hippocampal connection.
Title: New functions of Semaphorin 3E and its receptor PlexinD1 during developing and adult hippocampal formation.
that retinoic acid receptor-related orphan receptor alpha is a novel transcriptional regulator of SEMA3E-mediated neurovascular coupling in pathological retinal angiogenesis
Title: RORα modulates semaphorin 3E transcription and neurovascular interaction in pathological retinal angiogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2)
Targeted (4) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sema3e (e-PCR), detects polymorphism
- UniSTS:166293

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chemorepellent activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables semaphorin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables semaphorin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables semaphorin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in branching involved in blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in gonadotrophin-releasing hormone neuronal migration to the hypothalamus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neural crest cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in semaphorin-plexin signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in semaphorin-plexin signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in semaphorin-plexin signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: semaphorin-3E

Names: sema H; semaphorin-H

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011348.2 → NP_035478.2 semaphorin-3E precursor

See identical proteins and their annotated locations for NP_035478.2

Status: VALIDATED

Source sequence(s)

AC120420, AF034744, AK141295, AK142340, BE947109

Consensus CDS

CCDS19093.1

UniProtKB/Swiss-Prot

O09078, O09079, P70275, Q9QX23

Related

ENSMUSP00000073612.7, ENSMUST00000073957.8

Conserved Domains (3) summary

cd05871
Location:585 → 675

Ig_Semaphorin_classIII; Immunoglobulin (Ig)-like domain of class III semaphorin

cd11253
Location:49 → 519

Sema_3E; The Sema domain, a protein interacting module, of semaphorin 3E (Sema3E)

smart00423
Location:518 → 566

PSI; domain found in Plexins, Semaphorins and Integrins