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Pcsk7 proprotein convertase subtilisin/kexin type 7 [ Mus musculus (house mouse) ]

Gene ID: 18554, updated on 11-Apr-2024

Summary

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Official Symbol
Pcsk7provided by MGI
Official Full Name
proprotein convertase subtilisin/kexin type 7provided by MGI
Primary source
MGI:MGI:107421
See related
Ensembl:ENSMUSG00000035382 AllianceGenome:MGI:107421
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PC7; SPC7
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein processing. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in membrane and trans-Golgi network. Predicted to be integral component of Golgi membrane. Is expressed in early conceptus and oocyte. Orthologous to human PCSK7 (proprotein convertase subtilisin/kexin type 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 616.5), stomach adult (RPKM 205.4) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A5.2; 9 25.32 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (45817745..45843405)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (45906447..45932107)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:45655339-45655522 Neighboring gene beta-site APP cleaving enzyme 1 Neighboring gene ring finger protein 214 Neighboring gene predicted gene, 24646 Neighboring gene STARR-seq mESC enhancer starr_24009 Neighboring gene transgelin Neighboring gene microRNA 7087 Neighboring gene SID1 transmembrane family, member 2 Neighboring gene RIKEN cDNA A830035O19 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Proprotein convertase 7 (PCSK7) reduces apoA-V levels. Ashraf Y, et al. FEBS J, 2020 Aug. PMID 31945259
  2. Prohormone convertase 7 is necessary for the normal processing of cholecystokinin in mouse brain. Anyetei-Anum EN, et al. Biochem Biophys Res Commun, 2017 Jan 22. PMID 27923657
  3. Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion. Refaie S, et al. J Biol Chem, 2012 Apr 27. PMID 22396549, Free PMC Article
  4. Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study. Villeneuve P, et al. J Neurochem, 2002 Aug. PMID 12358783
  5. cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases. Seidah NG, et al. Proc Natl Acad Sci U S A, 1996 Apr 16. PMID 8622945, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PCSK7: A novel regulator of apolipoprotein B and a potential target against non-alcoholic fatty liver disease.
    Title: PCSK7: A novel regulator of apolipoprotein B and a potential target against non-alcoholic fatty liver disease.
  2. PC7 has a critical role in normal processing of cholecystokinin in mouse brain
    Title: Prohormone convertase 7 is necessary for the normal processing of cholecystokinin in mouse brain.
  3. PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation.
    Title: PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation.
  4. Data show that BDNF and PC7 mRNAs are colocalized in hippocampus and amygdala and that mature BDNF protein levels are reduced in these brain areas in proprotein convertase PC7 knockout mice.
    Title: Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice.
  5. overexpression of PCs, furin and PC5, but not PC7, which are all expressed in SMC, increase PKGI cleavage in a dose-dependent manner
    Title: Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport.
  6. Proprotein convertase PC7 enhances the activation of the EGF receptor pathway through processing of the EGF precursor.
    Title: Proprotein convertase PC7 enhances the activation of the EGF receptor pathway through processing of the EGF precursor.
  7. in binding VEGFR-2, furin and PC5 promote cleavage of N-and C-terminal VEGF-D propeptides, whereas PC7 promotes cleavage of the C-terminal propeptide only
    Title: Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein processing ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
proprotein convertase subtilisin/kexin type 7
Names
prohormone convertase 7
prohormone convertase PC7
proprotein convertase 7
proprotein convertase PC7
subtilisin-like proprotein convertase 7
subtilisin/kexin-like protease PC7
NP_001268863.1
NP_032820.2
XP_006510151.1
XP_006510152.1
XP_036010579.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281934.1 → NP_001268863.1  proprotein convertase subtilisin/kexin type 7 precursor

    See identical proteins and their annotated locations for NP_001268863.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC126804, AK165389, BC056456
    Consensus CDS
    CCDS40609.1
    UniProtKB/Swiss-Prot
    O08577, Q61139, Q922W4
    UniProtKB/TrEMBL
    Q3U920
    Related
    ENSMUSP00000150393.2, ENSMUST00000216672.2
    Conserved Domains (3) summary
    cd04059
    Location:144 → 438
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    pfam01483
    Location:524 → 611
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:52 → 140
    S8_pro-domain; Peptidase S8 pro-domain

  2. NM_008794.2 → NP_032820.2  proprotein convertase subtilisin/kexin type 7 precursor

    See identical proteins and their annotated locations for NP_032820.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK148416, BC056456
    Consensus CDS
    CCDS40609.1
    UniProtKB/Swiss-Prot
    O08577, Q61139, Q922W4
    UniProtKB/TrEMBL
    Q3U920
    Related
    ENSMUSP00000047508.7, ENSMUST00000039059.8
    Conserved Domains (3) summary
    cd04059
    Location:144 → 438
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    pfam01483
    Location:524 → 611
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:52 → 140
    S8_pro-domain; Peptidase S8 pro-domain

RNA

  1. NR_104055.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate internal exon and uses an alternate splice junction in the first exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC126804, BC056456
    Related
    ENSMUST00000215189.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    45817745..45843405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510089.3 → XP_006510152.1  proprotein convertase subtilisin/kexin type 7 isoform X3

    Conserved Domains (2) summary
    cd04059
    Location:144 → 377
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    pfam16470
    Location:52 → 140
    S8_pro-domain; Peptidase S8 pro-domain

  2. XM_036154686.1 → XP_036010579.1  proprotein convertase subtilisin/kexin type 7 isoform X1

    UniProtKB/Swiss-Prot
    O08577, Q61139, Q922W4
    UniProtKB/TrEMBL
    Q3U920
    Conserved Domains (3) summary
    cd04059
    Location:144 → 438
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    pfam01483
    Location:524 → 611
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:52 → 140
    S8_pro-domain; Peptidase S8 pro-domain

  3. XM_006510088.5 → XP_006510151.1  proprotein convertase subtilisin/kexin type 7 isoform X2

    Conserved Domains (2) summary
    cd04059
    Location:2 → 223
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    pfam01483
    Location:309 → 396
    P_proprotein; Proprotein convertase P-domain

RNA

  1. XR_004935338.1 RNA Sequence

  2. XR_001778808.3 RNA Sequence

  3. XR_001778807.3 RNA Sequence

  4. XR_870526.4 RNA Sequence

  5. XR_001778810.3 RNA Sequence

  6. XR_001778809.3 RNA Sequence

  7. XR_001778811.3 RNA Sequence

  8. XR_004935342.1 RNA Sequence

  9. XR_004935341.1 RNA Sequence

  10. XR_004935340.1 RNA Sequence

  11. XR_004935339.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61139.2 GenPept UniProtKB/Swiss-Prot:Q61139

Gene LinkOut

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