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ahsa-1 Activator of Hsp90 ATPase AHSA1-like N-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 180017, updated on 5-May-2024

Summary

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Gene symbol
ahsa-1
Gene description
Activator of Hsp90 ATPase AHSA1-like N-terminal domain-containing protein
Primary source
WormBase:WBGene00007235
Locus tag
CELE_C01G10.8
See related
AllianceGenome:WB:WBGene00007235
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATPase activator activity. Predicted to be involved in positive regulation of ATPase activity and protein folding. Predicted to be active in cytosol. Orthologous to several human genes including AHSA1 (activator of HSP90 ATPase activity 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (15084059..15085382, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene J domain-containing protein Neighboring gene MitMem_reg domain-containing protein;UNC-76 Neighboring gene putative tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial Neighboring gene Methylthioribose-1-phosphate isomerase Neighboring gene HpcH/HpaI aldolase/citrate lyase domain-containing protein Neighboring gene FIP (Fungus-Induced Protein) Related Neighboring gene FIP (Fungus-Induced Protein) Related Neighboring gene FIP (Fungus-Induced Protein) Related

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Challenging muscle homeostasis uncovers novel chaperone interactions in Caenorhabditis elegans. Frumkin A, et al. Front Mol Biosci, 2014. PMID 25988162, Free PMC Article
  2. Cdc37-Hsp90 complexes are responsive to nucleotide-induced conformational changes and binding of further cofactors. Gaiser AM, et al. J Biol Chem, 2010 Dec 24. PMID 20880838, Free PMC Article
  3. Downregulation of the Hsp90 system causes defects in muscle cells of Caenorhabditis elegans. Gaiser AM, et al. PLoS One, 2011. PMID 21980476, Free PMC Article
  4. Hsp90 in non-mammalian metazoan model systems. Haslbeck V, et al. Biochim Biophys Acta, 2012 Mar. PMID 21983200
  5. A Differentiation Transcription Factor Establishes Muscle-Specific Proteostasis in Caenorhabditis elegans. Bar-Lavan Y, et al. PLoS Genet, 2016 Dec. PMID 28036392, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-folding chaperone binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of ATP-dependent activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Activator of Hsp90 ATPase AHSA1-like N-terminal domain-containing protein
NP_506715.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    15084059..15085382 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_074314.7 → NP_506715.1  Activator of Hsp90 ATPase AHSA1-like N-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506715.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q93168
    Conserved Domains (2) summary
    cd08892
    Location:212 → 338
    SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins
    smart01000
    Location:29 → 160
    Aha1_N; Activator of Hsp90 ATPase, N-terminal
Nucleotide Protein
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