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Papln papilin, proteoglycan-like sulfated glycoprotein [ Mus musculus (house mouse) ]

Gene ID: 170721, updated on 5-Mar-2024

Summary

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Official Symbol
Paplnprovided by MGI
Official Full Name
papilin, proteoglycan-like sulfated glycoproteinprovided by MGI
Primary source
MGI:MGI:2386139
See related
Ensembl:ENSMUSG00000021223 AllianceGenome:MGI:2386139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E030033C16Rik
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization. Predicted to act upstream of or within negative regulation of peptidase activity. Located in basement membrane. Is expressed in alimentary system; male reproductive gland or organ; skin; and vagina. Orthologous to human PAPLN (papilin, proteoglycan like sulfated glycoprotein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in mammary gland adult (RPKM 17.7), ovary adult (RPKM 6.3) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 D1; 12 38.87 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (83809769..83841914)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (83762994..83795140)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7159 Neighboring gene presenilin 1 Neighboring gene STARR-positive B cell enhancer ABC_E3061 Neighboring gene farnesyl diphosphate synthetase pseudogene Neighboring gene NUMB endocytic adaptor protein Neighboring gene STARR-seq mESC enhancer starr_32718 Neighboring gene predicted gene, 46367 Neighboring gene endothelin converting enzyme 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Papilin in development; a pericellular protein with a homology to the ADAMTS metalloproteinases. Kramerova IA, et al. Development, 2000 Dec. PMID 11076767
  2. O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Du J, et al. Dev Biol, 2010 Oct 1. PMID 20637190, Free PMC Article
  3. Transcriptome-based systematic identification of extracellular matrix proteins. Manabe R, et al. Proc Natl Acad Sci U S A, 2008 Sep 2. PMID 18757743, Free PMC Article
  4. The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Naba A, et al. Mol Cell Proteomics, 2012 Apr. PMID 22159717, Free PMC Article
  5. Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. Desai J, et al. Hum Mol Genet, 2006 Apr 15. PMID 16537572

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basement membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
papilin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205343.1 → NP_001192272.1  papilin isoform 1 precursor

    See identical proteins and their annotated locations for NP_001192272.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC132954, AK053198, BC144975
    Consensus CDS
    CCDS56847.1
    UniProtKB/TrEMBL
    B7ZN28
    Related
    ENSMUSP00000113806.2, ENSMUST00000121733.8
    Conserved Domains (7) summary
    smart00209
    Location:30 → 81
    TSP1; Thrombospondin type 1 repeats
    pfam00014
    Location:771 → 822
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam05986
    Location:184 → 299
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam07679
    Location:1070 → 1141
    I-set; Immunoglobulin I-set domain
    pfam08686
    Location:1257 → 1289
    PLAC; PLAC (protease and lacunin) domain
    pfam16626
    Location:831 → 922
    Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
    cl11960
    Location:1157 → 1241
    Ig; Immunoglobulin domain

  2. NM_130887.3 → NP_570957.2  papilin isoform 2 precursor

    See identical proteins and their annotated locations for NP_570957.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC132954, BC132475
    Consensus CDS
    CCDS26031.1
    UniProtKB/Swiss-Prot
    A2RTE8, B2RQC4, Q99JQ8, Q9EPX2
    Related
    ENSMUSP00000021646.6, ENSMUST00000021646.6
    Conserved Domains (9) summary
    smart00209
    Location:30 → 81
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:184 → 299
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam16626
    Location:809 → 900
    Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
    pfam00014
    Location:749 → 801
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam07679
    Location:1048 → 1119
    I-set; Immunoglobulin I-set domain
    pfam08686
    Location:1235 → 1267
    PLAC; PLAC (protease and lacunin) domain
    pfam19030
    Location:367 → 425
    TSP1_ADAMTS; Thrombospondin type 1 domain
    cd00096
    Location:1059 → 1066
    Ig; Ig strand B [structural motif]
    cl11960
    Location:1135 → 1219
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    83809769..83841914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515505.5 → XP_006515568.1  papilin isoform X1

    See identical proteins and their annotated locations for XP_006515568.1

    UniProtKB/TrEMBL
    B7ZN28
    Conserved Domains (7) summary
    smart00209
    Location:30 → 81
    TSP1; Thrombospondin type 1 repeats
    pfam00014
    Location:771 → 822
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam05986
    Location:184 → 299
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam07679
    Location:1070 → 1141
    I-set; Immunoglobulin I-set domain
    pfam08686
    Location:1257 → 1289
    PLAC; PLAC (protease and lacunin) domain
    pfam16626
    Location:831 → 922
    Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
    cl11960
    Location:1157 → 1241
    Ig; Immunoglobulin domain

  2. XM_011244005.4 → XP_011242307.1  papilin isoform X1

    See identical proteins and their annotated locations for XP_011242307.1

    UniProtKB/TrEMBL
    B7ZN28
    Conserved Domains (7) summary
    smart00209
    Location:30 → 81
    TSP1; Thrombospondin type 1 repeats
    pfam00014
    Location:771 → 822
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam05986
    Location:184 → 299
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam07679
    Location:1070 → 1141
    I-set; Immunoglobulin I-set domain
    pfam08686
    Location:1257 → 1289
    PLAC; PLAC (protease and lacunin) domain
    pfam16626
    Location:831 → 922
    Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
    cl11960
    Location:1157 → 1241
    Ig; Immunoglobulin domain

  3. XM_036157202.1 → XP_036013095.1  papilin isoform X2

    UniProtKB/Swiss-Prot
    A2RTE8, B2RQC4, Q99JQ8, Q9EPX2
    Conserved Domains (9) summary
    smart00209
    Location:30 → 81
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:184 → 299
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam16626
    Location:809 → 900
    Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
    pfam00014
    Location:749 → 801
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam07679
    Location:1048 → 1119
    I-set; Immunoglobulin I-set domain
    pfam08686
    Location:1235 → 1267
    PLAC; PLAC (protease and lacunin) domain
    pfam19030
    Location:367 → 425
    TSP1_ADAMTS; Thrombospondin type 1 domain
    cd00096
    Location:1059 → 1066
    Ig; Ig strand B [structural motif]
    cl11960
    Location:1135 → 1219
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EPX2.2 GenPept UniProtKB/Swiss-Prot:Q9EPX2

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