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Adam11 a disintegrin and metallopeptidase domain 11 [ Mus musculus (house mouse) ]

Gene ID: 11488, updated on 12-May-2024

Summary

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Official Symbol
Adam11provided by MGI
Official Full Name
a disintegrin and metallopeptidase domain 11provided by MGI
Primary source
MGI:MGI:1098667
See related
Ensembl:ENSMUSG00000020926 AllianceGenome:MGI:1098667
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mdc
Summary
This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. The protein encoded by this gene is believed to lack metalloproteinase activity due to the lack of a critical catalytic motif. Mice lacking the encoded protein exhibit defects in spatial learning, motor coordination and altered perception of pain. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing. [provided by RefSeq, May 2016]
Expression
Broad expression in cerebellum adult (RPKM 47.6), cortex adult (RPKM 21.6) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Adam11 in Genome Data Viewer
Location:
11 E1; 11 66.48 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102652261..102671089)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102761413..102780263)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 43 Neighboring gene STARR-seq mESC enhancer starr_30819 Neighboring gene DBF4 zinc finger B Neighboring gene proteasome (prosome, macropain) subunit, alpha type 1 pseudogene Neighboring gene gap junction protein, gamma 1 Neighboring gene predicted gene, 22683

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Altered nociceptive response in ADAM11-deficient mice. Takahashi E, et al. Brain Res, 2006 Jun 30. PMID 16729981
  2. Developmental regulation and neuronal expression of the cellular disintegrin ADAM11 gene in mouse nervous system. Rybnikova E, et al. Neuroscience, 2002. PMID 12088751
  3. Antioxidant enzymes, free-radical damage, and response to paraquat in liver and kidney of long-living growth hormone receptor/binding protein gene-disrupted mice. Hauck SJ, et al. Horm Metab Res, 2002 Sep. PMID 12384824
  4. Deficits in spatial learning and motor coordination in ADAM11-deficient mice. Takahashi E, et al. BMC Neurosci, 2006 Feb 26. PMID 16504143, Free PMC Article
  5. Cloning and initial characterization of mouse meltrin beta and analysis of the expression of four metalloprotease-disintegrins in bone cells. Inoue D, et al. J Biol Chem, 1998 Feb 13. PMID 9461614

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In the ADAM11 mutant, GABAergic release was not altered, but the ultrarapid electrical signal was absent, demonstrating that the dense presynaptic cluster of Kv1 ion channels at these terminals mediate electrical transmission.
    Title: Selective Loss of Presynaptic Potassium Channel Clusters at the Cerebellar Basket Cell Terminal Pinceau in Adam11 Mutants Reveals Their Role in Ephaptic Control of Purkinje Cell Firing.
  2. Interaction proteomics revealed the interactors of Caspr2, including CNTN2, KCNAs, members of the ADAM family (ADAM22, ADAM23 and ADAM11), members of LGI family and MAGUKs (DLGs and MPPs).
    Title: Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes.
  3. ADAM11 may have a role in learning and motor coordination.
    Title: Deficits in spatial learning and motor coordination in ADAM11-deficient mice.
  4. ADAM11 may play a role in pain transmission and in inflammatory regulation mechanisms underlying changes in the threshold for pain perception.
    Title: Altered nociceptive response in ADAM11-deficient mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in behavioral response to acetic acid induced pain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in behavioral response to formalin induced pain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in multicellular organismal response to stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
disintegrin and metalloproteinase domain-containing protein 11
Names
a disintegrin and metalloprotease domain (ADAM) 11
metalloproteinase-like, disintegrin-like, and cysteine-rich protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110778.2 → NP_001104248.1  disintegrin and metalloproteinase domain-containing protein 11 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001104248.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). This isoform (1) may undergo proteolytic processing similar to isoform 2.
    Source sequence(s)
    AK157926, BC054536
    Consensus CDS
    CCDS48946.1
    UniProtKB/TrEMBL
    Q3TZE2, Q7TQG7
    Related
    ENSMUSP00000069466.6, ENSMUST00000068150.7
    Conserved Domains (6) summary
    smart00608
    Location:534 → 672
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:243 → 440
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:457 → 531
    Disintegrin; Disintegrin
    pfam01421
    Location:243 → 442
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:80 → 192
    Pep_M12B_propep; Reprolysin family propeptide
    pfam07974
    Location:681 → 713
    EGF_2; EGF-like domain

  2. NM_001417290.1 → NP_001404219.1  disintegrin and metalloproteinase domain-containing protein 11 isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AL929067

  3. NM_001417291.1 → NP_001404220.1  disintegrin and metalloproteinase domain-containing protein 11 isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AL929067

  4. NM_009613.3 → NP_033743.2  disintegrin and metalloproteinase domain-containing protein 11 isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_033743.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal segment in the 3' region, as compared to variant 1. The encoded isoform (2) has a shorter and different C-terminus, as compared to isoform 1.
    Source sequence(s)
    AK157926, AL929067, BC054536, CD353697
    Consensus CDS
    CCDS25503.1
    UniProtKB/Swiss-Prot
    A2AUA8, Q9R1V4
    UniProtKB/TrEMBL
    Q3TZE2
    Related
    ENSMUSP00000099370.5, ENSMUST00000103081.10
    Conserved Domains (6) summary
    smart00608
    Location:534 → 672
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:243 → 440
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:457 → 531
    Disintegrin; Disintegrin
    pfam01421
    Location:243 → 442
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:80 → 192
    Pep_M12B_propep; Reprolysin family propeptide
    pfam07974
    Location:681 → 713
    EGF_2; EGF-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    102652261..102671089
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532017.4 → XP_006532080.1  disintegrin and metalloproteinase domain-containing protein 11 isoform X4

    UniProtKB/TrEMBL
    Q3TZE2
    Conserved Domains (5) summary
    smart00608
    Location:555 → 693
    ACR; ADAM Cysteine-Rich Domain
    pfam07974
    Location:702 → 734
    EGF_2; EGF-like domain
    pfam00200
    Location:478 → 551
    Disintegrin
    pfam01421
    Location:264 → 463
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:50 → 193
    Pep_M12B_propep; Reprolysin family propeptide

  2. XM_006532018.2 → XP_006532081.1  disintegrin and metalloproteinase domain-containing protein 11 isoform X6

    UniProtKB/TrEMBL
    Q3TZE2
    Conserved Domains (5) summary
    smart00608
    Location:555 → 693
    ACR; ADAM Cysteine-Rich Domain
    pfam07974
    Location:702 → 734
    EGF_2; EGF-like domain
    pfam00200
    Location:478 → 551
    Disintegrin
    pfam01421
    Location:264 → 463
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:50 → 193
    Pep_M12B_propep; Reprolysin family propeptide

  3. XM_006532014.2 → XP_006532077.1  disintegrin and metalloproteinase domain-containing protein 11 isoform X1

    UniProtKB/TrEMBL
    Q3TZE2
    Conserved Domains (5) summary
    smart00608
    Location:555 → 693
    ACR; ADAM Cysteine-Rich Domain
    pfam07974
    Location:702 → 734
    EGF_2; EGF-like domain
    pfam00200
    Location:478 → 551
    Disintegrin
    pfam01421
    Location:264 → 463
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:50 → 193
    Pep_M12B_propep; Reprolysin family propeptide

  4. XM_006532016.2 → XP_006532079.1  disintegrin and metalloproteinase domain-containing protein 11 isoform X3

    UniProtKB/TrEMBL
    Q3TZE2
    Conserved Domains (5) summary
    smart00608
    Location:555 → 693
    ACR; ADAM Cysteine-Rich Domain
    pfam07974
    Location:702 → 734
    EGF_2; EGF-like domain
    pfam00200
    Location:478 → 551
    Disintegrin
    pfam01421
    Location:264 → 463
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:50 → 193
    Pep_M12B_propep; Reprolysin family propeptide

  5. XM_030245479.2 → XP_030101339.1  disintegrin and metalloproteinase domain-containing protein 11 isoform X10

    Conserved Domains (3) summary
    smart00608
    Location:276 → 414
    ACR; ADAM Cysteine-Rich Domain
    pfam00200
    Location:199 → 272
    Disintegrin
    pfam01421
    Location:1 → 184
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease

  6. XM_006532020.4 → XP_006532083.1  disintegrin and metalloproteinase domain-containing protein 11 isoform X9

    Conserved Domains (3) summary
    smart00608
    Location:330 → 468
    ACR; ADAM Cysteine-Rich Domain
    pfam00200
    Location:253 → 326
    Disintegrin
    pfam01421
    Location:39 → 238
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease

  7. XM_017314225.2 → XP_017169714.1  disintegrin and metalloproteinase domain-containing protein 11 isoform X8

    Conserved Domains (3) summary
    smart00608
    Location:389 → 527
    ACR; ADAM Cysteine-Rich Domain
    pfam00200
    Location:312 → 385
    Disintegrin
    pfam01421
    Location:98 → 297
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease

  8. XM_006532019.2 → XP_006532082.1  disintegrin and metalloproteinase domain-containing protein 11 isoform X7

    Conserved Domains (3) summary
    smart00608
    Location:389 → 527
    ACR; ADAM Cysteine-Rich Domain
    pfam00200
    Location:312 → 385
    Disintegrin
    pfam01421
    Location:98 → 297
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease

RNA

  1. XR_388328.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R1V4.2 GenPept UniProtKB/Swiss-Prot:Q9R1V4

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