ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif 1 [Pongo abelii (Sumatran orangutan)] - Gene

Summary

Gene symbol: ADAMTS1
Gene description: ADAM metallopeptidase with thrombospondin type 1 motif 1
Locus tag: CR201_G0027191
See related: Ensembl:ENSPPYG00000011310
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Pongo abelii
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPonAbe1-v2.0_pri (GCF_028885655.2)	22	NC_072007.2 (36994554..37004452, complement)
RS_2023_04	previous assembly	NHGRI_mPonAbe1-v1.1-hic.freeze_pri (GCF_028885655.1)	21	NC_072006.1 (31197809..31207136, complement)

Chromosome 22 - NC_072007.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D21S1964 (e-PCR)
- UniSTS:63269

A005R14 (e-PCR)
- UniSTS:61779

SHGC-51859 (e-PCR)
- UniSTS:61021

STS-R76276 (e-PCR)
- UniSTS:32124

G32278 (e-PCR)
- UniSTS:116876

MARC_10651-10652:1000474642:1 (e-PCR)
- UniSTS:267184

ADAMTS1_209 (e-PCR)
- UniSTS:276969

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: A disintegrin and metalloproteinase with thrombospondin motifs 1

NP_001126571.1

EC 3.4.24.-

XP_063576855.1

EC 3.4.24.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001133099.1 → NP_001126571.1 A disintegrin and metalloproteinase with thrombospondin motifs 1

See identical proteins and their annotated locations for NP_001126571.1

Status: PROVISIONAL

Source sequence(s)

CR860556

UniProtKB/TrEMBL

A0A2J8UKL2, Q5R6D5

Related

ENSPPYP00000012633.2, ENSPPYT00000013133.3

Conserved Domains (6) summary

smart00209
Location:562 → 614

TSP1; Thrombospondin type 1 repeats

cd04273
Location:258 → 463

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01421
Location:258 → 467

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:73 → 166

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:725 → 842

ADAM_spacer1; ADAM-TS Spacer 1

cl15456
Location:468 → 548

ADAM_CR; ADAM cysteine-rich

RefSeqs of Annotated Genomes: GCF_028885655.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

Genomic

NC_072007.2 Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

Range

36994554..37004452 complement

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GenBank, FASTA, Sequence Viewer (Graphics)