U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C [ Felis catus (domestic cat) ]

Gene ID: 100144583, updated on 16-Nov-2023

Summary

Go to the top of the page Help
Gene symbol
APOBEC3C
Gene description
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Felis catus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Also known as
APOBEC3; APOBEC3CA
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: B4
Exon count:
4
Annotation release Status Assembly Chr Location
105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) B4 NC_058374.1 (132502418..132508873)

Chromosome B4 - NC_058374.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC109501928 Neighboring gene uncharacterized LOC123386743 Neighboring gene DNA dC->dU-editing enzyme APOBEC-3Ca Neighboring gene apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3Z3

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_058374.1 Chromosome B4 Reference F.catus_Fca126_mat1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Expression of APOBEC3 Lentiviral Restriction Factors in Cats. Troyer RM, et al. Viruses, 2019 Sep 7. PMID 31500260, Free PMC Article
  2. Absence of A3Z3-Related Hypermutations in the env and vif Proviral Genes in FIV Naturally Infected Cats. Cano-Ortiz L, et al. Viruses, 2018 May 31. PMID 29857485, Free PMC Article
  3. Feline Immunodeficiency Virus Evolutionarily Acquires Two Proteins, Vif and Protease, Capable of Antagonizing Feline APOBEC3. Yoshikawa R, et al. J Virol, 2017 Jun 1. PMID 28331087, Free PMC Article
  4. Determinants of FIV and HIV Vif sensitivity of feline APOBEC3 restriction factors. Zhang Z, et al. Retrovirology, 2016 Jul 1. PMID 27368163, Free PMC Article
  5. Species-specific differences in the ability of feline lentiviral Vif to degrade feline APOBEC3 proteins. Yoshikawa R, et al. Microbiol Immunol, 2016 Apr. PMID 26935128, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of APOBEC3 Lentiviral Restriction Factors in Cats.
    Title: Expression of APOBEC3 Lentiviral Restriction Factors in Cats.
  2. The correlation between APOBEC A3Z3 haplotypes in domestic cats and the frequency of hypermutations in the FIV vif and env genes were assessed.
    Title: Absence of A3Z3-Related Hypermutations in the env and vif Proviral Genes in FIV Naturally Infected Cats.
  3. findings demonstrate that FIV, a pathogenic lentivirus in domestic cats, antagonizes feline APOBEC3 proteins by both Vif and a viral protease.
    Title: Feline Immunodeficiency Virus Evolutionarily Acquires Two Proteins, Vif and Protease, Capable of Antagonizing Feline APOBEC3.
  4. study identified in feline APOBEC3 residues important for binding of FIV Vif and a unique protein domain insertion (linker)
    Title: Determinants of FIV and HIV Vif sensitivity of feline APOBEC3 restriction factors.
  5. Non-primate lentiviral Vif being incapable of counteracting a natural host's anti-viral activity mediated via APOBEC3 protein.
    Title: Species-specific differences in the ability of feline lentiviral Vif to degrade feline APOBEC3 proteins.
  6. Authors show that the Bel2 domain of feline foamy virus Bet is essential for the inactivation of APOBEC3 cytidine deaminase restriction factors.[APOBEC3]
    Title: Identification of the feline foamy virus Bet domain essential for APOBEC3 counteraction.
  7. The FFV accessory protein Bet protein binds to cat APOBEC3 proteins. [APOBEC3]
    Title: Molecular and functional interactions of cat APOBEC3 and feline foamy and immunodeficiency virus proteins: different ways to counteract host-encoded restriction.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytidine deaminase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables deoxycytidine deaminase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA cytosine deamination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in DNA demethylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytidine to uridine editing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in P-body IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
DNA dC->dU-editing enzyme APOBEC-3Ca
Names
Antiviral cytidine deaminase A3Ca
apolipoprotein B editing enzyme catalytic polypeptide-like 3C
probable DNA dC->dU-editing enzyme APOBEC-3C
NP_001116508.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001123036.1 → NP_001116508.1  DNA dC->dU-editing enzyme APOBEC-3Ca

    See identical proteins and their annotated locations for NP_001116508.1

    Status: PROVISIONAL

    Source sequence(s)
    EU057981
    UniProtKB/TrEMBL
    A9QGZ8, A9QGZ9
    Conserved Domains (3) summary
    cd01283
    Location:29 → 143
    cytidine_deaminase; Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on ...
    pfam05240
    Location:132 → 172
    APOBEC_C; APOBEC-like C-terminal domain
    pfam08210
    Location:20 → 189
    APOBEC_N; APOBEC-like N-terminal domain

RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference F.catus_Fca126_mat1.0 Primary Assembly

Genomic

  1. NC_058374.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

    Range
    132502418..132508873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.