GEO DataSets

Analysis of ankle joints of wild type animals following treatment with sera from K/BxN mice to induce arthritis. Results compared to arthritic ankles from Mmp-8 deficient mutants (GDS5243) and provide insight into the role of Mmp-8 in the pathogenesis of arthritis.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 disease state sets

Platform:

GPL6246

Series:

GSE22971

6 Samples

Download data: CEL

(Submitter supplied) Rheumatoid arthritis is an autoimmune disease in which joint inflammation lead to progressive cartilage and bone destruction. Matrix metalloproteinases (MMP) implicated in homeostasis of extracellular matrix (ECM) play a central role in cartilage degradation. The aim of this study was to investigate the role of MMP-8 (collagenase-2) suppression in the K/BxN serum-transfer arthritis model.

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS5243 GDS5244

Platform:

GPL6246

12 Samples

Download data: CEL

Analysis of ankle joints of Mmp-8 deficient mutants following treatment with sera from K/BxN mice to induce arthritis. Mmp-8 encodes a metalloproteinase. Results compared to arthritic ankles from wild type animals (GDS5244) and provide insight into the role of Mmp-8 in the pathogenesis of arthritis.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 disease state sets

Platform:

GPL6246

Series:

GSE22971

6 Samples

Download data: CEL

(Submitter supplied) Transcriptional profiling of mouse chondrocytes comparing chondrocytes infected with empty adenovirus and Epas1 adenovirus. RNA was extracted from each chondrocytes. We used microarrays to determine the effect of Epas1 overexpression on chondrocytes and identify the noble regulatory molecules during osteoarthritic pathogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7202

4 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling of mouse fibroblast-like synoviocytes (FLS) comparing FLS infected with empty adenovirus and Epas1 adenovirus. RNA was extracted from each FLS. We used microarrays to determine the effect of Epas1 overexpression on FLS and identifying the noble regulatory molecules during rheumatoid arthritic pathogenesis

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL16570

6 Samples

Download data: CEL

(Submitter supplied) Purpose: The goal of this study is to evaluate Il1rn-/- Tregs features by bulk RNA sequencing (RNA-seq) of Tregs from WT and Il1rn-/- lymph nodes. Methods: mRNA profiles of isolated CD4+Foxp3eGFP+ from lymph nodes of three 35-day-old wild-type (WT) and three Il1rn-/- mice were generated by deep sequencing. RNA was extracted from sorted cells (5X10^4) using a Qiagen RNeasy Micro Kit. RNA-seq was performed using the Smart-Seq2 platform. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

14 Samples

Download data: CSV

(Submitter supplied) Gene expression profiles in the tarsal bones and joints of mice that performed treadmill exercise vs. those who were not exercised were compared. Exercise induced the downregulation of genes and signaling pathways that mediates and promotes the inflammatory process and triggered the upregulation of genes associated to cartilage remodeling and bone mineralization.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL18099

1 Sample

Download data: XLSX