GEO DataSets

Analysis of lateral cortices of brains from Wistar males for up to 48 hours following traumatic brain injury (TBI). TBI induced by lateral moderate fluid percussion. Results provide insight into the nature of temporal events that occur at the molecular level following TBI.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 2 shock, 4 time sets

Platform:

GPL1355

Series:

GSE24047

16 Samples

Download data: CEL

(Submitter supplied) Time dependent-profiles in the gene expression level following lateral moderate fluid percussion injury in the rat brain We used microarray to elucidate relationship between the alteration of gene expression levels and the progression of brain damages following traumatic brain injury.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS4911

Platform:

GPL1355

16 Samples

Download data: CEL

(Submitter supplied) Traumatic brain injury (TBI) can lead to significant neuropsychiatric problemsand neurodegenerative pathologies, which develop and persist years after injury. Neuroinflammatory processes evolve over this same period. Cortical mRNA analysis showed a robust contribution of microglia to neuroinflammatory pathways that persisted over time post-injury. These data also indicate that inflammation persists in the subacute and chronic time points after TBI, which may affect surrounding neurons, oligodendrocytes and astrocytes. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

8 Samples

Download data: MTX, TSV

(Submitter supplied) Traumatic brain injury (TBI) can lead to significant neuropsychiatric problems and neurodegenerative pathologies, which develop and persist years after injury. Neuroinflammatory processes evolve over this same period. Therefore, we aimed to determine the contribution of microglia to neuropathology at acute (1-day post-injury; dpi), subacute (7 dpi), and chronic (30 dpi) time-points. Microglia were depleted with PLX5622, a CSF1R antagonist, prior to midline fluid percussion injury in male mice and cortical neuropathology/inflammation was assessed using a neuropathology mRNA panel. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL29331

55 Samples

Download data: RCC

(Submitter supplied) Renal ischemia reperfusion injury (I/R) has great clinical relevance and many treatments and hospitalizations are associated with this pathological process. Animal models are widely used in the development of kidney I/R studies and numerous papers have been published in this field in recent years suggesting that the nature of the animal species used in these models can lead to a different response to ischemic insult. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL2996

12 Samples

Download data: TXT

(Submitter supplied) Traumatic brain injury (TBI) initiates a complex sequence of destructive and neuroprotective cellular responses. The initial mechanical injury is followed by an extended time period of secondary brain damage. Due to the complicated pathological picture a better understanding of the molecular events occurring during this secondary phase of injury is needed. This study was aimed at analysing gene expression patterns following cerebral cortical contusion in rat using high throughput microarray technology with the goal of identifying genes involved in an early and in a more delayed phase of trauma, as genomic responses behind secondary mechanisms likely are time-dependent. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1921

7 Samples

Download data

(Submitter supplied) Summary: Brain trauma is a major cause of morbidity and mortality, both in adult and pediatric populations. Much of the functional deficit derives from delayed cell death resulting from induction of neurotoxic factors that overwhelm endogenous neuroprotective responses. Hypothesis: Gene expression profiling across species and models may help identify candidate molecular pathways induced by brain injury, some of which may provide novel targets for therapeutic intervention. more...

Organism:

Mus musculus; Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS2850 GDS2851

Platforms:

GPL85 GPL81

61 Samples

Download data: CEL

Analysis of brain at various time points up to 21 days following lateral fluid percussion-induced brain injury. Delayed cell death following trauma results in brain damage. Results provide insight into the mechanisms underlying brain damage after traumatic injury.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 protocol, 7 time sets

Platform:

GPL85

Series:

GSE2392

39 Samples

Download data: CEL

Analysis of brain at various time points up to 72 hours following lateral controlled cortical impact injury. Delayed cell death following trauma results in brain damage. Results provide insight into the mechanisms underlying brain damage after traumatic injury.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 protocol, 5 time sets

Platform:

GPL81

Series:

GSE2392

22 Samples

Download data: CEL

(Submitter supplied) RNA samples were prepared from ipsilateral rat hippocampi 3 hr and 24 hr following lateral cortical impact injury and compared to samples from sham-operated controls. For details please see Matzilevich et al., J Neurosci Res 2002 Mar 1;67(5):646-63. Keywords = Brain injury Keywords: time-course

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

3 Samples

Download data

(Submitter supplied) Comparison of gene expression in the hippocampus of 10 day old sham-injured and brain-injured BALB-c mice, and examine the effects of high dose Epo on these conditions at 24 hours following injury.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6096

24 Samples

Download data: CEL

(Submitter supplied) In contrast to the considerable in vitro and in vivo data demonstrating a decrease in cytochrome P450 (CYP) activity in inflammation and infection, clinically, traumatic brain injury (TBI) results in an increase in CYP and UDP glucuronosyltransferases (UGT) activity. The objective of this study was to determine the effects of TBI alone and along with treatment with either erythropoietin (EPO) or anakinra on gene expression of hepatic inflammatory proteins and drug metabolizing enzymes and transporters in a cortical contusion impact (CCI) injury animal model. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6247

50 Samples

Download data: CEL

(Submitter supplied) To address the hypothesis that silencing deleterious or protective injury-induced genes in the rat hippocampus will reduce or increase the numbers of injured hippocampal neurons, alter cellular pathways essential for neuronal function and improve or worsen functional outcome after traumatic brain injury (TBI), we evaluated the effects of silencing neuronal nitric oxide synthase (nNOS) and glutathione peroxidase-1 (GPx-1) expression in the injured rat hippocampus.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL14746

15 Samples

Download data: TXT

(Submitter supplied) Expression of 59 complemet genes at day 3, day 7, day 28, year 1, and year 2 post injury

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL30084

24 Samples

Download data: RCC

(Submitter supplied) Expression of 757 neuroinflammaiton-associated genes in vehicle and complement inhibitor treated TBI brains at days 3, 7 and 28 post injury

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL30083

21 Samples

Download data: RCC

(Submitter supplied) Abstract Background Traumatic brain injury (TBI) results in irreversible damage at the site of impact and initiates cellular and molecular processes that lead to secondary neural injury in the surrounding tissue. We used microarray analysis to determine which genes, pathways and networks were significantly altered using a rat model of TBI. Adult rats received a unilateral controlled cortical impact (CCI) and were sacrificed 24h post-injury. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

9 Samples

Download data: CEL

(Submitter supplied) White blood cells (WBCs) express tens of thousands of genes. Their expression levels are modified by genetic and external factors. The purpose of the present study was to investigate the effects of acute exercise on gene expression profiles (GEPs) of WBCs and to identify suitable genes which may serve as surrogate markers for monitoring exercise and training load. Five male probands performed an exhaustive treadmill test (ET) at 80% of their VO2max, and a moderate treadmill test (MT) at 60% VO2max for exactly the same time one to two week later. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2310

Platform:

GPL571

20 Samples

Download data

Analysis of white blood cells (WBCs) from 5 males following exhaustive or moderate exercise. Results provide insight into the effects of exercise at the molecular level and the feasibility of using gene expression profiles of WBCs to monitor exercise and training load.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 5 individual, 4 time sets

Platform:

GPL571

Series:

GSE3606

20 Samples

Download data

(Submitter supplied) To investigate genome-wide gene expression changes induced by an NMDA receptor positive allosteric modulator in neuronal cultures using next-generation sequencing

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24688

8 Samples

Download data: CSV, TXT

(Submitter supplied) Gene expression analysisis of NR2A and NR2B containing NMDA receptors after treatment with AP5, NVP-AAM077 and Ro25-6981

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7202

20 Samples

Download data: TXT