GEO DataSets

Analysis of patient-derived colorectal cancer explants (PDCCE), generated by direct transplantation of human colorectal cancer (CRC) tissues into NOD-SCID mice, and matched patient CRC primary tumors. Results provide insight into the degree to which PDCCEs represent their primary human counterparts.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 tissue sets

Platform:

GPL570

Series:

GSE35144

64 Samples

Download data: CEL

(Submitter supplied) Mouse models have been developed to investigate colorectal cancer etiology and evaluate new anti-cancer therapies. While genetically engineered and carcinogen-induced mouse models have provided important information with regard to the mechanisms underlying the oncogenic process, xenograft models remain the standard for the evaluation of new chemotherapy and targeted drug treatments for clinical use. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4381

Platform:

GPL570

64 Samples

Download data: CEL

(Submitter supplied) The Illumina GoldenGate® methylation array was used to evaluate DNA methylation at 1,505 CpG sites in 807 cancer-related genes in 91 consecutive CRC samples and 28 matched normal colonic mucosa.

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL9183

119 Samples

Download data

(Submitter supplied) Despite advances in contemporary chemotherapeutic strategies, long term survival still remains elusive for patients with metastatic colorectal cancer. A better understanding of the molecular markers of drug sensitivity to match therapy with patient is needed to improve clinical outcomes. In this study, we used in vitro drug sensitivity data from the NCI-60 cell lines together with their Affymetrix microarray data to develop a gene expression signature to predict sensitivity to oxaliplatin. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

42 Samples

Download data: CEL