GEO DataSets

Analysis of five brain regions closely connected to the emotion-regulating parts of the limbic system, isolated by LCM from CD-1 males selectively bred for high (HAB), normal (NAB), or low (LAB) anxiety-related behavior. Results provide insight into the molecular mechanisms underlying anxiety.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 disease state, 5 tissue sets

Platform:

GPL6481

Series:

GSE29015

75 Samples

Download data

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS4001 GDS4002

Platforms:

GPL7467 GPL6481

148 Samples

Download data: TXT

(Submitter supplied) Investigating the molecular basis and correlates of anxiety-related and depression-like behaviors, we generated a mouse model consisting of high (HAB), normal (NAB) and low (LAB) anxiety-related behavior mice. We utilized the elevated plus-maze for testing the genetic predisposition to anxiety-related behavior and, consequently, used this as selection criterion for the inbreeding of our animals. In depression-related tests, HAB mice display a more passive, depression-like coping strategy than LAB mice, resembling clinical comorbidity of anxiety and depression as observed in psychiatric patients. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6481

78 Samples

Download data: TXT

(Submitter supplied) Investigating the molecular basis and correlates of anxiety-related and depression-like behaviors, we generated a mouse model consisting of high (HAB) and low (LAB) anxiety-related behavior mice. We utilized the elevated plus-maze for testing the genetic predisposition to anxiety-related behavior and, consequently, used this as selection criterion for the inbreeding of our animals. In depression-related tests, HAB mice display a more passive, depression-like coping strategy than LAB mice, resembling clinical comorbidity of anxiety and depression as observed in psychiatric patients. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7467

70 Samples

Download data: TXT

Analysis of seven brain regions closely connected to the emotion-regulating parts of the limbic system, isolated by micropunching from CD-1 males selectively bred for high (HAB) or low (LAB) anxiety-related behavior. Results provide insight into the molecular mechanisms underlying anxiety.

Organism:

Mus musculus

Type:

Expression profiling by array, log2 ratio, 7 tissue sets

Platform:

GPL7467

Series:

GSE29015

70 Samples

Download data: TXT

(Submitter supplied) The early-life environment critically influences neurodevelopment and later psychological health. To elucidate neural and environmental elements that shape emotional behavior, we developed a rat model of individual differences in temperament and environmental reactivity. We selectively bred rats for high versus low behavioral response to novelty and found that high-reactive (bred high-responder, bHR) rats displayed greater risk-taking, impulsivity and aggression relative to low-reactive (bred low-responder, bLR) rats, which showed high levels of anxiety/depression-like behavior and certain stress vulnerability. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL19519

160 Samples

Download data: PAIR

(Submitter supplied) prenatal stress response, genetic modification Background: Prenatal stress (PS) exposure has been shown to increase the risk for emotional disorders in later life. Furthermore, the serotonin transporter (5-HTT) genotype is suggested to exert a modulating effect on the association between early life stress and the risk for depression. In the present study, we use a 5-HTT x PS paradigm to investigate whether the effects of PS are dependent upon the 5-HTT genotype. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4524

Platform:

GPL1261

12 Samples

Download data: CEL

Analysis of hippocampi of prenatally-stressed (PS), female offspring of serotonin transporter (5-Htt) +/- parents. Depressive behavior of PS, 5-Htt +/- mice is most pronounced in female offspring. Results provide insight into molecular basis of behavioral effects of gene × environment interactions.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation, 2 stress sets

Platform:

GPL1261

Series:

GSE26025

12 Samples

Download data: CEL

(Submitter supplied) The molecular etiology of invididual differences in complex behavior traits and susceptibility to psychiatric illness remains incomplete. Using an unbiased genetic approach in a mouse model, Quantitative Trait Loci (QTL) influencing anxiety-like behaviors and beta-carboline-induced seizure vulnerability have been mapped to the distal portion of mouse chromosome 10 and an interval specific congenic strain (ISCS; A.B6chr10; 66 cM to telomere) was developed. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL340 GPL4055 GPL339

36 Samples

Download data: CEL, CHP, TXT

(Submitter supplied) MAP kinase signaling has been implicated in brain development, long-term memory, and the response to antidepressants. Inducible Braf knockout mice enabled us to unravel a new role of neuronal MAPK signaling for emotional behavior. Braf mice that were induced during adulthood showed normal anxiety but increased depression-like behavior, in accordance with pharmacological findings. In contrast, the inactivation of Braf in the juvenile brain leads to normal depression-like behavior but decreased anxiety in adults. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6105

36 Samples

Download data: TXT

(Submitter supplied) Purpose: To investigate the effect that selective breeding for high and low OFA has on gene expression Methods: Male and female High and Low Activity mice (n=4 per strain/sex) were euthanized at postnatal day 70 and hippocampi were immediately collected. Paired-end RNA-seq methods were employed to assess hippocampal mRNA expression. Results: The expression of thousands of transcripts were altered by selective breeding for high and low OFA.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

16 Samples

Download data: XLSX