GEO DataSets

Analysis of 2, 6, and 10 month old transgenic (Tg) thyroids expressing RET/PTC3 fusion gene or E7 human papillomavirus 16 oncoprotein. The two Tg populations with different initiating mutations both develop thyroid carcinoma. Results provide insight into the different steps leading to carcinoma.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 age, 3 strain sets

Platform:

GPL1261

Series:

GSE10743

9 Samples

Download data: CEL

(Submitter supplied) The RET/PTC3 (RP3) fusion gene is the most frequent mutation found in radiation-induced papillary thyroid cancers (PTC). Several studies suggest that the RET/PTC rearrangement is an initiating event in tumorigenesis. E7 is an oncoprotein derived from the Human Papilllomavirus 16 (HPV16) responsible for most cervical carcinoma in women. We studied here the sequence of events leading to thyroid cancer in Tg-RP3 and Tg-E7 mice expressing the transgene exclusively in the thyroid under the control of thyroglobulin (Tg) promoter. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3319

Platform:

GPL1261

9 Samples

Download data: CEL

(Submitter supplied) We show that numerous miRNAs are transcriptionally up-regulated in papillary thyroid carcinoma (PTC) tumors compared with unaffected thyroid tissue. Among the predicted target genes of the three most upregulated miRNAs (miRs 221, 222 and 146b), only less than 15% showed significant downexpression in transcript level between tumor and unaffected tissue. The KIT gene which is known to be downregulated by miRNAs 221 and 222 displayed dramatic loss of transcript and protein in those tumors that had abundant mir-221, mir-222, and mir-146b transcript. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1665

Platform:

GPL570

18 Samples

Download data: CEL

Analysis of papillary thyroid carcinoma (PTC) tumors from 9 patients. PTC accounts for about 80% of all thyroid cancers. These results, together with those obtained from custom miRNA chips, indicate the involvement of several miRNAs and the receptor tyrosine kinase KIT in PTC pathogenesis.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state, 9 individual sets

Platform:

GPL570

Series:

GSE3467

18 Samples

Download data: CEL

(Submitter supplied) Side population (SP) cells are enriched with genes involved in stem cell activity and/or lineage specifications. Stem cell marker genes are upregulated after partial thyroidectomy.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7202

18 Samples

Download data: TXT

(Submitter supplied) Mutations of the thyrotropin receptor leading to constitutive activation of the cAMP cascade are responsible for the development of hot nodules, if arising in a somatic cell, and non-auto-immune hyperthyroidism, when occurring in a germinal cell. An animal model of constitutive activation of the thyroid cAMP cascade has been obtained by generating transgenic mice expressing the adenosine receptor (Tg-A2aR) under the control of the thyroglobulin promoter. more...

Organism:

Mus musculus

Type:

Expression profiling by array

5 related Platforms

10 Samples

Download data

(Submitter supplied) Mutations of the thyrotropin receptor leading to constitutive activation of the cAMP cascade are responsible for the development of hot nodules, if arising in a somatic cell, and non-auto-immune hyperthyroidism, when occurring in a germinal cell. An animal model of constitutive activation of the thyroid cAMP cascade has been obtained by generating transgenic mice expressing the adenosine receptor (Tg-A2aR) under the control of the thyroglobulin promoter. more...

Organism:

Mus musculus

Type:

Expression profiling by array

5 related Platforms

5 Samples

Download data

(Submitter supplied) Mutations of the thyrotropin receptor leading to constitutive activation of the cAMP cascade are responsible for the development of hot nodules, if arising in a somatic cell, and non-auto-immune hyperthyroidism, when occurring in a germinal cell. An animal model of constitutive activation of the thyroid cAMP cascade has been obtained by generating transgenic mice expressing the adenosine receptor (Tg-A2aR) under the control of the thyroglobulin promoter. more...

Organism:

Mus musculus

Type:

Expression profiling by array

5 related Platforms

5 Samples

Download data

(Submitter supplied) The HPV16-E7 oncoprotein and 17β-estradiol are import factors for the induction of premalignant lesions and cervical cancer. The study of these factors is crucial for a better understanding of cervical tumorigenesis. In this study, we performed a microarray analysis to obtain a global gene expression profile induced by both, HPV16-E7 and 17β-estradiol in cervical tissue of K14E7 transgenic mice. We found that 17β-estradiol is the main cause of the up-regulation of a large number of cellular genes involved in the immune response whereas E7 oncoprotein mainly affects the cellular metabolism. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

15 Samples

Download data: CEL