GEO DataSets

Comparison of septal myocardial tissue samples from 13 patients with dilated cardiomyopathy (DCM) to those from 15 patients with non-failing (NF) hearts. DCM is a common cause of heart failure. Results contribute to the identification of a gene expression signature for DCM.

Organism:

Homo sapiens

Type:

Expression profiling by array, log2 ratio, 2 disease state sets

Platform:

GPL3050

Series:

GSE3586

28 Samples

Download data: GPR

(Submitter supplied) Dilated cardiomyopathy (DCM) is a common cause of heart failure and a leading cause of cardiac transplantation in western countries. The robust predictive expression profile of cardiomyopathic and NF hearts as well as the functional classification can help to identify promising candidates for DCM and may improve the early diagnosis of cardiomyopathy. Keywords: disease state analysis

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2206

Platform:

GPL3050

28 Samples

Download data: GPR

(Submitter supplied) Dilated cardiomyopathy (DCM) is a common cause of heart failure and a leading cause of cardiac transplantation in western countries. The robust predictive expression profile of cardiomyopathic and NF hearts as well as the functional classification can help to identify promising candidates for DCM and may improve the early diagnosis of cardiomyopathy. Keywords: disease state analysis

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2205

Platform:

GPL96

12 Samples

Download data: CEL, EXP

Comparison of subendocardial left ventricular tissue samples from 7 patients with dilated cardiomyopathy (DCM) to those from 5 patients with non-failing (NF) hearts. DCM is a common cause of heart failure. Results contribute to the identification of a gene expression signature for DCM.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state sets

Platform:

GPL96

Series:

GSE3585

12 Samples

Download data: CEL, EXP

(Submitter supplied) Microarrays have been widely used for the analysis of gene expression and several commercial platforms are available. The combined use of multiple platforms can overcome the inherent biases of each approach, and may represent an alternative that is complementary to RT-PCR for identification of the more robust changes in gene expression profiles. In this paper, we combined statistical and functional analysis for the cross platform validation of two oligonucleotide-based technologies, Affymetrix (AFFX) and Applied Biosystems (ABI), and for the identification of differentially expressed genes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL1426 GPL570

12 Samples

Download data: CEL

(Submitter supplied) Using a canine custom retinal cDNA microarray our aim is to identify normal gene expression profiling for retina and frontal, occipital and temporal brain cortices Keywords: retina-brain comparisons

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platforms:

GPL3951 GPL3957

11 Samples

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(Submitter supplied) GPL9743 represents two different print sets, v1 and v2. While the order of the clones are not exactly the same in v1 and v2, the clones themselves are identical. The Platform data table reflects a condensed representation of the print sets' replicate features. The v1 and v2 full array layout (.gal) files, representing all of the individual features, are linked below as supplementary files. Protocol: EST clones were obtained from a normalized canine retinal library cloned into pGEM 11ZF(+) vector (Promega). more...

Organism:

Canis lupus familiaris

1 Series

12 Samples

Download data: GAL

(Submitter supplied) Pre-LVAD and explanted ischemic and nonischemic cardiomyopathy and nonfailing hearts all normalized with RMA Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1362

Platform:

GPL96

37 Samples

Download data: CEL

Analysis of myocardial tissues from nonischemic (NICM) and ischemic cardiomyopathy (ICM) patients. NICM and ICM, major forms of dilated cardiomyopathy leading to congestive heart failure, have similar presentations but differ in pathophysiology, prognosis, and response to therapy.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 disease state sets

Platform:

GPL96

Series:

GSE1869

37 Samples

Download data: CEL

(Submitter supplied) Study of atherosclerosis using 51 human coronary artery segments Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1597

Platform:

GPL1790

51 Samples

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(Submitter supplied) Cardiovascular specific human oligonucleotide array (20433 unique probes) developed between Agilent Technologies and the Quertermous Lab at Stanford University.

Organism:

Homo sapiens

1 DataSet

1 Series

51 Samples

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Analysis of 51 coronary artery segments from the explanted hearts of 22 cardiac patients. Results provide insight into the pathogenesis and progression of atherosclerotic disease.

Organism:

Homo sapiens

Type:

Expression profiling by array, log2 ratio, 22 individual sets

Platform:

GPL1790

Series:

GSE2143

51 Samples

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(Submitter supplied) The goal of this dataset was to use RNA-seq in human heart tissue to delineate etiology-specific gene expression signatures in heart failure.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

64 Samples

Download data: TXT

(Submitter supplied) Microarray technology is a powerful tool able to measure RNA expression for thousands of genes at once. Various studies have been published comparing competing platforms with mixed results: some find agreement, others do not. As the number of researchers starting to use microarrays and the number of cross platform meta-analysis studies rapidly increase, appropriate platform assessments become more important. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

4 related Platforms

32 Samples

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(Submitter supplied) A consortium of ten labs from the DC and Baltimore area was formed to compare three leading platforms. Each lab was given identical RNA samples (A1 and B1) which were processed according to what each lab considered best practice. Five of the labs used Affymetrix GeneChips, three used two-color spotted cDNA arrays, and two used two-color long oligo arrays. Keywords: repeat sample

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL1953

4 Samples

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(Submitter supplied) Oligonucleotide microarray analysis of left ventricular tissues from 3 Great dane dogs with dilated cardiomyopathy and 3 control dogs was performed. Three hundred and twenty three differentially expressed transcripts were detected. The transcript demonstrating the highest degree of upregulation was FKBP12.6 (calstabin2) and the transcript with the greatest amount of down regulation was triadin. Both of these transcripts are critical to proper functioning of the cardiac ryanodine receptor. more...

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3738

6 Samples

Download data: CEL, CHP

(Submitter supplied) A comparison of epigenetic nuclear DNA methylation and gene expression changes between human dialated cardiomypathy left ventricle samples and non-failing cardiac left ventricule samples This study addresses how depletion of huaman cardiac left ventricle mitochondrial DNA and epigentic nuclear DNA methylation promote cardiac dysfunction in human dilated cardiomyopathy.

Organism:

Homo sapiens

Type:

Expression profiling by array; Methylation profiling by genome tiling array

Platforms:

GPL16284 GPL15338

40 Samples

Download data: CALLS, GFF, PAIR, TXT

(Submitter supplied) Dilated cardiomyopathy (DCM) is characterized by left ventricular or biventricular enlargement with systolic dysfunction. To date, the underlying molecular mechanisms of dilated cardiomyopathy pathogenesis have not been fully elucidated, although some insights have been presented. In this study, we combined public database resources and a doxorubicin-induced DCM mouse model to explore the significant genes of DCM in full depth. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28330

6 Samples

Download data: TXT

(Submitter supplied) RNA form the heart a goupe of 9 patients with end stage cardiomyopathy (CAD) and 11 patiensts with coronary artery disease (CAD) was hybridized against pooled RNA form 4 normal nonfailing hearts. Keywords: repeat sample

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL1707

25 Samples

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(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Methylation profiling by array

Platforms:

GPL10558 GPL13534

57 Samples

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