GEO DataSets

Analysis of diaphragms of alpha2-laminin deficient dy/dy animals. Alpha-2 laminin is important in muscle cell attachment, and its deficiency underlies classical congenital muscular dystrophy. Results provide insight into the events that link alpha2-laminin deficiency with muscle fiber necrosis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL339

Series:

GSE3252

8 Samples

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(Submitter supplied) Laminin (merosin) deficient muscular dystrophy in dy/dy mouse diaphragm muscle, 8 weeks old Keywords: muscle, muscular dystrophy, laminin, merosin, diaphragm, mouse

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1778

Platform:

GPL339

8 Samples

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(Submitter supplied) Determination of gene expression changes in extraocular muscle of mdx (dystrophin-deficient) mice at postnatal ages 7, 14, 23, 28, 56, and 112 days. 3 independent replicates/age/strain. Data form part of publication: Human Molecular Genetics 13:257-269, 2004. Keywords = microarray Keywords = muscle Keywords: time-course

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS638

Platform:

GPL81

36 Samples

Download data: CEL

Temporal analysis of diaphram muscle from dystrophin-deficient mdx mice, a Duchenne muscular dystrophy (DMD) model. Postnatal ages 7 to 112 days examined. Results provide insight into mechanisms of muscular dystrophy pathogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 6 age, 2 strain sets

Platform:

GPL81

Series:

GSE1026

36 Samples

Download data: CEL

(Submitter supplied) Three subjects with Duchenne muscular dystrophy (8.3, 10.4, and 16.7 years old) were studied. Baseline studies included stable isotope infusion followed by gastrocnemius muscle biopsy to determine myosin heavy chain synthesis rates. RNA was isolated from the muscle biopsy as well. The subjects were then treated for 3 months with oxandrolone (a synthetic anabolic steroid, 0.1 mg/kg/day) and the studies repeated. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS1333 GDS1334

Platforms:

GPL96 GPL97

12 Samples

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Analysis of gastrocnemius muscle biopsy specimens from Duchenne muscular dystrophy (DMD) patients before and after 3 months of treatment with 0.1mg/kg/day oxandrolone, a synthetic anabolic steroid. Results provide insight into mechanisms underlying the beneficial effect of oxandrolone in DMD.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 3 individual sets

Platform:

GPL97

Series:

GSE1764

6 Samples

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Analysis of gastrocnemius muscle biopsy specimens from Duchenne muscular dystrophy (DMD) patients before and after 3 months of treatment with 0.1mg/kg/day oxandrolone, a synthetic anabolic steroid. Results provide insight into mechanisms underlying the beneficial effect of oxandrolone in DMD.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 3 individual sets

Platform:

GPL96

Series:

GSE1764

6 Samples

Download data

(Submitter supplied) By comparing the transcriptome from proximal (quadriceps femoris, QF) and distal (tibialis anterior, TA)muscle groups in dysferlin deficient mouse muscle (the SJL mutation bred onto C57BL/10 to produces C57BL/10-SJL.Dysf) with proximal and distal muscle groups from control C57BL/10 mice of an equivalent age (3-weeks old, prior to the onset of overt pathology) we aim to address the issues of muscle selectivity in this this form of muscular dystrophy. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1233

Platform:

GPL81

12 Samples

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Comparison of the proximal quadriceps femoris muscle to the distal tibialis anterior muscle of 3 week old dysferlin deficient mutants. Dysferlin mutations can result in the neuromuscular disorders Limb-Girdle muscular dystrophy type 2B and Myoshi myopathy.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 2 tissue sets

Platform:

GPL81

Series:

GSE2629

12 Samples

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(Submitter supplied) Muscle biopsies taken from vastus lateralis muscle of 30 normal subjects and 19 FSHD subjects (see PubMed ID 17151338) Affymetrix U133A and U133B arrays were scanned both before (S1) and after (S2) antibody enhancement. Effects of age and sex in normal subjects reported previously under GSE362, GSE674, and GSE9676. Keywords: facioscapulohumeral dystrophy, skeletal muscle

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL96 GPL97

196 Samples

Download data: CEL

(Submitter supplied) Genome-wide expression profiling of the retinoschisin deficient retina in C57CL/6 mice. Keywords: Genetic modification

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2636

Platform:

GPL339

6 Samples

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Analysis of retinas from postnatal day 7 mutants lacking retinoschisin (RS1h), an animal model for retinoschisis (RS). RS is a recessive retinal dystrophy accompanied by macular disease often resulting in early-onset vision loss. Results provide insight into the pathogenesis of RS.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL339

Series:

GSE5581

6 Samples

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(Submitter supplied) Molecular definition of human extraocular muscles (EOM). Human EOM were compared with limb (quadriceps femoris) muscle. Keywords = Eye Keywords = EOM Keywords = Muscle Keywords = DMD Keywords = Myasthenia Gravis Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS525

Platform:

GPL96

5 Samples

Download data: CEL

Molecular definition of extraocular muscle (EOM). Autopsy superior rectus EOM compared with biopsy limb quadriceps femoris muscle.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 tissue sets

Platform:

GPL96

Series:

GSE873

5 Samples

Download data: CEL

(Submitter supplied) It is unknown how soon the diaphragm begins to start the process of atrophy following the start of MV. We hypothesized that genes responsible for maintaining diaphragmatic contractile function, stress response, energy transduction would be altered over the course of a 5 hour cardiothoracic surgery.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4308

Platform:

GPL570

10 Samples

Download data: CEL

Analysis of paired diaphragm biopsies from 5 patients during cardiothoracic surgery: the 1st as soon as diaphragm was exposed, the 2nd as late in surgery as possible (4.9 ± 1.8 hrs between biopsies). Results provide insight into diaphragm muscle biology after prolonged cardiothoracic procedures.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 5 age, 5 individual, 2 specimen sets

Platform:

GPL570

Series:

GSE19533

10 Samples

Download data: CEL

(Submitter supplied) Gene expression profiling with microarrays was used to identify genes differentially expressed in the lungs of B6 and BALB CF mice compared to non-CF littermates Keywords: disease state analysis

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1941

Platform:

GPL1261

23 Samples

Download data: CEL

Analysis of lungs of C57BL/6J (B6) or BALB/c (BALB) animals deficient for cystic fibrosis transmembrane conductance regulator (CFTR). B6 background animals have a higher propensity to develop CF lung disease. Results suggest the variable severity of CF is controlled by multiple genetic factors.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 gender, 2 genotype/variation, 2 strain sets

Platform:

GPL1261

Series:

GSE3100

23 Samples

Download data: CEL

(Submitter supplied) Mutations in the gene encoding laminin a2 chain cause congenital muscular dystrophy, MDC1A. In skeletal muscle, laminin a2 chain binds at least two receptor complexes; the dystrophin-glycoprotein complex and integrin a7b1. To gain insight into the molecular mechanisms underlying this disorder, we performed gene expression profiling of laminin a2 chain deficient mouse limb muscle. One of the down-regulated genes encodes a protein called calcium and integrin binding protein 2 (Cib2) whose expression and function is unknown. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3371

Platform:

GPL1261

6 Samples

Download data: CEL

Analysis of hind limb skeletal muscle from 4-week old dy3K/dy3K animals, which completely lack expression of laminin α2 chain. Mutations in the laminin alpha2 chain gene cause congenital muscular dystrophy type 1A (MDC1A). Results provide insight into molecular mechanisms underlying this disorder.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE12049

6 Samples

Download data: CEL