Alpha2-laminin deficient dy/dy model of muscular dystrophy: diaphragm
Summary:
Analysis of diaphragms of alpha2-laminin deficient dy/dy animals. Alpha-2 laminin is important in muscle cell attachment, and its deficiency underlies classical congenital muscular dystrophy. Results provide insight into the events that link alpha2-laminin deficiency with muscle fiber necrosis.
van Lunteren E, Moyer M, Leahy P. Gene expression profiling of diaphragm muscle in alpha2-laminin (merosin)-deficient dy/dy dystrophic mice. Physiol Genomics 2006 Mar 13;25(1):85-95. PMID: 16368874