Similar studies for GEO DataSets (Select 1486) - GEO DataSets

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Items: 19

Select item 14861.

Serum response factor null mutation effect on neonatal cardiomyocytes

Analysis of serum response factor (SRF)-null neonatal cardiomyocytes. SRF is a transcriptional regulator required for mesodermal development and implicated in myogenesis. Results provide insight into the role of SRF in regulating genetic programs important for controlling cardiomyocyte function.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 genotype/variation sets

Platform:: GPL1261
Series:: GSE3181
6 Samples

Download data

DataSet

Accession:: GDS1486

ID:: 1486

Select item 2000031812.

SRF-null neonatal cardiomyocytes

(Submitter supplied) Serum Response Factor (SRF) is a transcriptional regulator required for mesodermal development. Numerous studies have implicated SRF as a central regulator of muscle gene expression and myogenesis. In this present study we used a loss of function approach to delineate the role of SRF in cardiac myocyte gene expression and function. In SRF null neonatal cardiomyocytes, we observe severe defects in the contractile apparatus, including Z-disc and stress fiber formation, as well as mislocalization and/or attenuation of sarcomeric proteins. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS1486
Platform:: GPL1261
6 Samples

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Series

Accession:: GSE3181

ID:: 200003181

Select item 2000406773.

Gene expression analysis in mice with heart muscle-specific repression of CELF activity (MHC-CELFdelta)

(Submitter supplied) Members of the CUG-BP, Elav-like family (CELF) regulate alternative splicing in the heart. In MHC-CELFdelta transgenic mice, CELF splicing activity is inhibited postnatally in heart muscle via expression of a nuclear dominant negative CELF protein under an a-myosin heavy chain promoter. MHC-CELFdelta mice develop dilated cardiomyopathy characterized by alternative splicing defects, enlarged hearts, and severe contractile dysfunction. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6887
12 Samples

Download data: TXT

Series

Accession:: GSE40677

ID:: 200040677

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001160304.

Next Generation Sequencing Quantitative Analysis of Srf-regulated Transcriptomes in mouse cardiomyocytes during cardiomyocyte maturation [exp2]

(Submitter supplied) The goal of this study is to analyze the impact of Srf overexpression on transcription during cardiomyocyte maturation in mouse

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
6 Samples

Download data: TXT

Series

Accession:: GSE116030

ID:: 200116030

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Select item 2001095045.

Genome-wide SRF occupancy on chromatin in mouse heart ventricles

(Submitter supplied) The goal of this study is to analyze genome-wide Srf binding to chromatin in mouse heart during heart maturation

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL19057
7 Samples

Download data: BW

Series

Accession:: GSE109504

ID:: 200109504

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001094256.

Next Generation Sequencing Quantitative Analysis of Srf-regulated Transcriptomes in mouse cardiomyocytes during cardiomyocyte maturation [exp1]

(Submitter supplied) The goal of this study is to analyze the role of Srf in transcriptional analysis during cardiomyocyte maturation in mouse

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
12 Samples

Download data: TXT

Series

Accession:: GSE109425

ID:: 200109425

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000607727.

Genome-wide analysis of kainic acid-induced gene expression in dentate gyrus from CTR and SRF knockout mice.

(Submitter supplied) To identify genes regulated by SRF in response to increased neuronal activity whole-genome expression profiling (Illumina Mouse WG-6 microarrays) of kainic acid-induced genes were performed. We found that loss of SRF in DG leads to specific deficits in activity-induced gene expression. Identified genes functions are associated with synapse plasticity, epilepsy, outgrowth of neurites, behavior and MAPK signaling pathway.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL17543
22 Samples

Download data: TXT

Series

Accession:: GSE60772

ID:: 200060772

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Select item 2000550908.

SRF is required for neutrophil migration in response to inflammation

(Submitter supplied) RNA expression in Srf wildtype and knockout primary bone marrow derived mature neutrophils was determined via RNA sequencing

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
4 Samples

Download data: TXT

Series

Accession:: GSE55090

ID:: 200055090

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000074129.

The influence of the deletion of Serum Response Factor in B cells

(Submitter supplied) Serum response factor (SRF), a MADS-box transcription factor, is essential for murine embryonic development and for the function of muscle cells and neurons. SRF and its transcriptional co-factors are broadly expressed. To determine the in vivo role of SRF in developing lymphocytes we specifically inactivated the murine Srf gene during T or B cell development using lymphocyte-specific Cre transgenic mouse lines. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS2805
Platform:: GPL339
4 Samples

Download data: CEL

Series

Accession:: GSE7412

ID:: 200007412

Select item 280510.

Serum response factor deficient B cells

Analysis of IgM+ IgD+ B cells lacking the Serum response factor (SRF) gene. SRF is a MADS-box transcription factor that is essential in embryonic development and in neuron and muscle cell function. Results provide insight into the role of SRF in lymphocyte development.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 genotype/variation sets

Platform:: GPL339
Series:: GSE7412
4 Samples

Download data: CEL

DataSet

Accession:: GDS2805

ID:: 2805

Select item 20004440611.

Srf is essential for mesodermal cell migration during elongation of the embryonic body axis

(Submitter supplied) Timecourse analysis of SRF dependent genes in the nascent mesoderm of mouse embryos. Srf was conditionally deleted by a T::cre driver and the three embryonic stages analyzed represent embryos before onset of the phenotype (E8.5) and progressive appearance of the phenotype (E8.75 and E9.0).

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
24 Samples

Download data: TXT

Series

Accession:: GSE44406

ID:: 200044406

Select item 20001004512.

Disruption of the Circadian Clock within the Cardiomyocyte

(Submitter supplied) Disruption of the Circadian Clock within the Cardiomyocyte Influences Myocardial Contractie Function, Metabolism, and Gene Expression Virtually every mammalian cell, including cardiomyocytes, possesses an intrinsic circadian clock. The role of this transcriptionally-based molecular mechanism in cardiovascular biology is poorly understood. We hypothesized that the circadian clock within the cardiomyocyte influences diurnal variations in myocardial biology. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6333
130 Samples

Download data: XLS

Series

Accession:: GSE10045

ID:: 200010045

Select item 20005420913.

Serum Response Factor binding in Dstn-corn1 mutant and WT murine cornea

(Submitter supplied) We report the application of chromatin immunoprecipitation sequencing to identify binding sites of the transcription factor serum response factor (SRF) in the cornea of WT and Dstn-corn1 mutant mice

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
3 Samples

Download data: BW, TXT, XLS

Series

Accession:: GSE54209

ID:: 200054209

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20004968814.

Gene expression data from Dstncorn1 mutant, rescued and WT cornea after genetic ablation of Srf from the corneal epithelium

(Submitter supplied) The purpose of this study is to characterize gene expression changes that occur when conditional knock-out of Srf rescues mutant phenotypes in the cornea of Dstncorn1 mice. This study uses a unique model combining genetic and genomic approaches to identify genes that are regulated by SRF.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
9 Samples

Download data: CEL, CHP

Series

Accession:: GSE49688

ID:: 200049688

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Select item 20018662615.

RNA sequencing in iAM-1 differentiated cells and RnSbk2 knockdown

(Submitter supplied) RNA sequencing in iAM-1 differentiated cells and RnSbk2 knockdown

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25947
12 Samples

Download data: XLSX

Series

Accession:: GSE186626

ID:: 200186626

PubMed Similar studies SRA Run Selector

Select item 20016476316.

RNA sequencing of iAM-1 cells at different stages during one cycle of differentiation and subsequent dedifferentiation

(Submitter supplied) RNA sequencing of iAM-1 cells at different stages during one cycle of differentiation and subsequent dedifferentiation

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL22396
36 Samples

Download data: XLSX

Series

Accession:: GSE164763

ID:: 200164763

PubMed Similar studies SRA Run Selector

Select item 20019643917.

Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL22396 GPL20084
21 Samples

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Series

Accession:: GSE196439

ID:: 200196439

PubMed Full text in PMC Similar studies

Select item 20019643818.

Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart [ChIP-seq]

(Submitter supplied) Cardiac contractile strength is recognised as highly pH-sensitive, but less is known about the influence of pH on cardiac gene expression, which may be relevant during changes in myocardial metabolism or vascularization in development or disease. We sought evidence for pH-responsive cardiac genes and a context in which this has physiological relevance. pHLIP, a peptide-based reporter of acidity, revealed a non-uniform pH landscape in early-postnatal myocardium, dissipating in later life. more...