GSE198906[Accession] - GEO DataSets - NCBI

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Select item 2001989061.

Control of pancreatic islet function and glucose homeostasis by a novel microexon program misregulated in type 2 diabetes

(Submitter supplied) Pancreatic islets control glucose homeostasis by the balanced secretion of insulin and other hormones, and its abnormal function causes diabetes or hypoglycemia. Here, we uncover a conserved program of alternative microexons included in mRNAs of islet cells, particularly in genes involved in vesicle transport and exocytosis. Islet microexons (IsletMICs) are regulated by the RNA binding protein SRRM3 and represent a subset of the larger neural program that are particularly sensitive to the levels of this protein. more...

Organism:: Homo sapiens; Mus musculus; Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL16791 GPL17021 GPL18694
25 Samples

Download data: TXT

Series

Accession:: GSE198906

ID:: 200198906

PubMed Similar studies

Select item 1000186942.

Illumina HiSeq 2500 (Rattus norvegicus)

Organism:: Rattus norvegicus

485 Series
13105 Samples

Platform

Accession:: GPL18694

ID:: 100018694

Select item 1000170213.

Illumina HiSeq 2500 (Mus musculus)

Organism:: Mus musculus

10784 Series
293965 Samples

Platform

Accession:: GPL17021

ID:: 100017021

Select item 1000167914.

Illumina HiSeq 2500 (Homo sapiens)

Organism:: Homo sapiens

11859 Series
340151 Samples

Platform

Accession:: GPL16791

ID:: 100016791

Select item 3059599085.

INS1E cells siRNA Srrm3 replicate 3

Organism:: Rattus norvegicus

Source name:: INS1E cells

Platform:: GPL18694
Series:: GSE198906

Download data: TXT

Sample

Accession:: GSM5959908

ID:: 305959908

SRA Run Selector

Select item 3059599076.

INS1E cells siRNA Srrm3 replicate 2

Organism:: Rattus norvegicus

Source name:: INS1E cells

Platform:: GPL18694
Series:: GSE198906

Download data: TXT

Sample

Accession:: GSM5959907

ID:: 305959907

SRA Run Selector

Select item 3059599067.

INS1E cells siRNA Srrm3 replicate 1

Organism:: Rattus norvegicus

Source name:: INS1E cells

Platform:: GPL18694
Series:: GSE198906

Download data: TXT

Sample

Accession:: GSM5959906

ID:: 305959906

SRA Run Selector

Select item 3059599058.

INS1E cells siRNA control replicate 3

Organism:: Rattus norvegicus

Source name:: INS1E cells

Platform:: GPL18694
Series:: GSE198906

Download data: TXT

Sample

Accession:: GSM5959905

ID:: 305959905

SRA Run Selector

Select item 3059599049.

INS1E cells siRNA control replicate 2

Organism:: Rattus norvegicus

Source name:: INS1E cells

Platform:: GPL18694
Series:: GSE198906

Download data: TXT

Sample

Accession:: GSM5959904

ID:: 305959904

SRA Run Selector

Select item 30595990310.

INS1E cells siRNA control replicate 1

Organism:: Rattus norvegicus

Source name:: INS1E cells

Platform:: GPL18694
Series:: GSE198906

Download data: TXT

Sample

Accession:: GSM5959903

ID:: 305959903

SRA Run Selector

Select item 30595990211.

Mouse islets Srrm3+/+ female 12 week-old

Organism:: Mus musculus

Source name:: Islets

Platform:: GPL17021
Series:: GSE198906

Download data: TXT

Sample

Accession:: GSM5959902

ID:: 305959902

SRA Run Selector

Select item 30595990112.

Mouse islets Srrm3-/- female 12 week-old

Organism:: Mus musculus

Source name:: Islets

Platform:: GPL17021
Series:: GSE198906

Download data: TXT

Sample

Accession:: GSM5959901

ID:: 305959901

SRA Run Selector

Select item 30595990013.

Mouse islets Srrm3+/- female 12 week-old

Organism:: Mus musculus

Source name:: Islets

Platform:: GPL17021
Series:: GSE198906

Download data: TXT

Sample

Accession:: GSM5959900

ID:: 305959900

SRA Run Selector

Select item 30595989914.

Mouse islets Srrm3+/+ male 10 week-old

Organism:: Mus musculus

Source name:: Islets

Platform:: GPL17021
Series:: GSE198906

Download data: TXT

Sample

Accession:: GSM5959899

ID:: 305959899

SRA Run Selector

Select item 30595989815.

Mouse islets Srrm3+/+ female 10 week-old

Organism:: Mus musculus

Source name:: Islets

Platform:: GPL17021
Series:: GSE198906

Download data: TXT

Sample

Accession:: GSM5959898

ID:: 305959898

SRA Run Selector

Select item 30595989716.

Mouse islets Srrm3-/- male 10 week-old

Organism:: Mus musculus

Source name:: Islets

Platform:: GPL17021
Series:: GSE198906

Download data: TXT

Sample

Accession:: GSM5959897

ID:: 305959897

SRA Run Selector

Select item 30595989617.

Mouse islets Srrm3-/- female 10 week-old

Organism:: Mus musculus

Source name:: Islets

Platform:: GPL17021
Series:: GSE198906

Download data: TXT

Sample

Accession:: GSM5959896

ID:: 305959896

SRA Run Selector

Select item 30595989518.

Mouse islets Srrm3+/- male 10 week-old

Organism:: Mus musculus

Source name:: Islets

Platform:: GPL17021
Series:: GSE198906

Download data: TXT

Sample

Accession:: GSM5959895

ID:: 305959895

SRA Run Selector

Select item 30595989419.

Mouse islets Srrm3+/- female 10 week-old

Organism:: Mus musculus

Source name:: Islets

Platform:: GPL17021
Series:: GSE198906

Download data: TXT

Sample

Accession:: GSM5959894

ID:: 305959894

SRA Run Selector

Select item 30595989320.

EndoC-BH1 cells siRNA SRRM3 replicate 3

Organism:: Homo sapiens

Source name:: EndoC-BH1 cells

Platform:: GPL16791
Series:: GSE198906

Download data: TXT

Sample

Accession:: GSM5959893

ID:: 305959893

SRA Run Selector

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