4DLQ


Conserved Protein Domain Family
GAIN
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pfam16489: GAIN 
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GPCR-Autoproteolysis INducing (GAIN) domain
The GAIN a domain of alpha-helices and beta-strands that is found in cell-adhesion GPCRs and precedes the GPS motif where the autoproteolysis occurs, family, pfam01825. The full GAIN domain, comprises the GPS and the GAIN, in cell-adhesion GPCRs, and is the functional unit for autoproteolysis. The GPS motif at the end of the GAIN domain is an ancient domain that exists in primitive ancestor organizms, and the full GAIN + GPS is conserved in all cell-adhesion GPCRs and all PKD1-related proteins.
Links
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Statistics
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PSSM-Id: 465137
Aligned: 92 rows
Threshold Bit Score: 117.368
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4DLQ_A         93 NAANIASELARHTR-GSIYAGDVSSSVKLMEQL---------LDILDAQLQalrpieresagknynkmhkrertckDYIK 162  Norway rat
XP_002921796  188 EPVTLLQEVYRDSV-KDLSPTDIITYVEILAES---------SPLLGDMNStnsak---------------dalsnATLT 242 
XP_019812783   54 EPVALLREVYRNSL-KDLSPMDIIAYTEVLAES---------SPLLGYMNSsnsak---------------dtssnSTLT 108 
Q9HBW9        138 EPVALLQEVYRNSV-TDLSPTDIITYIEILAES---------SSLLGYKNNtisak---------------dtlsnSTLT 192  human
XP_023365550  186 EPVALLQEVYRSSA-TDLSPMDIITYIEILAEL---------SPLLGYMNNtvstk---------------dtppnTTLT 240 
EHB01762      138 EPVTLLQKIYRNSM-TDISLMDIITYIEILAKS---------SPLLGYMNNtvsdk---------------dtfsnSTLT 192 
Q923X1        187 EQTTLLQEIYRNSE-AELSLMDIVTYIEILTES---------SSLLGHPNSttsyk---------------dahfnSTLT 241  house mouse
Q9ESC1        186 EQLTLLHEIYKNSE-AELSLVDIVTYIEILTES---------SSLQGYIKNttspk---------------dayfgSALT 240  Norway rat
EKC38753      280 SIEDVANKLKEQTGtENLGAGDLKKVSDIITKMgrgfkipgsVDKkekr-----------------------ekleKFSM 336 
EGT35073      317 GLPEFLRKLGSETR-RPLVGGDLPRVIRLLEKT---------VDVIAEEPWafk--------------------hlQLTN 366 

4DLQ_A        163 AVV-ETVDNLLRPEALESWKDMNATEQVHTAtmLLDVLEEGAFLLADNVREPA-RFLAAKQNVVLEVTVLSTEGQVQEL- 239  Norway rat
XP_002921796  243 EFV-KTVNNFVQKDAFIVWDKLSMNHRRTHLtkLMHVAEQATLRISQNFQKTI-QFDTNSSDIALKTFFFDSHHIKHTh- 319 
XP_019812783  109 EFV-KTLNNFVQKDTFTVWDKLSTNQRITHLtkLIHTAEQATLRISQNFQKTT-QFDTNSSDIALKAFFFDSHHIK-YIh 185 
Q9HBW9        193 EFV-KTVNNFVQRDTFVVWDKLSVNHRRTHLtkLMHTVEQATLRISQSFQKTT-EFDTNSTDIALKVFFFDSYNMKHIh- 269  human
XP_023365550  241 EFV-KTMNNFIQKDTFMIWDKLPTHRRQTHLtkLMHTAEQATLRITQSFQKTT-QFDANSSDVALKVFFLDPNHMTHIh- 317 
EHB01762      193 EFV-KTMNNFIQKDTFKIWDKLSSNHRRAHLtkLMHTAEQATLRISQNFQKTT-QFDTNSTDIALKVFFFDSYHMKHTh- 269 
Q923X1        242 EFG-ETINNFVERSTHKMWDQLPTNHRRLHLtkLMHTAELVTLQIAQNTQKNS-QFDMNSTDLALKVFAFDSTHMKHAh- 318  house mouse
Q9ESC1        241 EFG-KTVNNFVEKNTHEMWDQLPTNRRRLHLtkLMHAAEHVTLQISQNIQKNT-QFDMNSTDLALKVFVFDSVHMKHTh- 317  Norway rat
EKC38753      337 SIA-ETGSNILSEKQSSSWEELPENNKTQVAasFLVSMETTGFNIADNLEEAD-SIVSSNENLFMEVSAVKVTRDKQAV- 413 
EGT35073      367 KRLvEVMNYML--RNQEIWGSWEVRKRKEFAsqFILATEKAMIVSAKGMQSSVeSNVLVQPAITVEISHKIKMSSQPTDy 444 

4DLQ_A        240 -VFPQe----YASESSIQLSANTIKQ-NsrngvVKVVFILYNNLGLFLSTenatvklAGEAGTGGPGGASL-VVNSQVIA 312  Norway rat
XP_002921796  320 pYMNVd-------GDYIKIFPKRKAAyDsy-gnVAVAFLYYKSIGPLFSSsd---nfLSEPQSSDNSEEEE-RVISSVIS 387 
XP_019812783  186 pHMNMd-------GDNIKIFPKRKTAyDsn-gsVAVAFLYYKSIGPLFSSsd----nlLEPQSYDKAEEEG-RVISSVIS 252 
Q9HBW9        270 pHMNMd-------GDYINIFPKRKAAyDsn-gnVAVAFVYYKSIGPLLSSsd---nfLLKPQNYDNSEEEE-RVISSVIS 337  human
XP_023365550  318 pHMKVd-------GDYINIFPKKRASfDsd-gnVAVAFLYYKSMGPLLSSsn---tiFLEPQNYDNSEEEE-KVISSVIS 385 
EHB01762      270 pHMNVd-------GDYIKVFPKRKAAyNle-gnVAVAFLYYKSIGSLLSSsd---nfSLEPQFSDNSEEQE-RVISSVIS 337 
Q923X1        319 pHMNVd-------GGYVKISPRRKAAhGtt-gnVVVAFLCYKSIGPLLSSsd---nfLLDTQN-DNSEGKE-KVISSVIS 385  house mouse
Q9ESC1        318 pHMNVd-------GGYVKISPRRKSAyDpn-gnVIVAFLCYRSIGPLLSSsd---dfLLGAQS-DNSKGKE-KVISSVIS 384  Norway rat
EKC38753      414 -TYPSse-nqKWKDDQITIPMEDIEA-LseggiTKVVVFVYQNMDELMT------------TKRN----TS-FINSNILS 473 
EGT35073      445 iLFPSaalwngqnVDNVNIPRDAILkvs--qdeTQVFFSSFDNIGHQMTPld----vTVPITGTDKTEVRKrRVVSRIVG 518 

4DLQ_A        313 ASINK 317  Norway rat
XP_002921796  388 VSISS 392 
XP_019812783  253 LSISS 257 
Q9HBW9        338 VSMSS 342  human
XP_023365550  386 VSISS 390 
EHB01762      338 VSINS 342 
Q923X1        386 ASISS 390  house mouse
Q9ESC1        385 ASISS 389  Norway rat
EKC38753      474 ASIMS 478 
EGT35073      519 ASLIE 523
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