2NRF,3ODJ


Conserved Protein Domain Family
Rhomboid

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pfam01694: Rhomboid 
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Rhomboid family
This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.
Statistics
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PSSM-Id: 426384
Aligned: 60 rows
Threshold Bit Score: 82.2699
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2NRF_A    39 PTLKFEFWRYFTHALMHFSLMHILFNLLWWWYLGGAVEKRL-----GSGKLIVITLI-----SALLSGYVQQKFSGP--- 105 Escherichia coli
Q12270    47 SLFKLQMSRLSLYPLIHLSLPHLLFNVLAIWAPLNLFEETH-----GTVYTGVFLNL-----SALFAGILYCLLGKLlyp 116 Saccharomyces cerev...
Q9M1B5    45 TAIEGHYWRMITSALSHISVLHLVFNMSALWSLGVV--EQLghvglGTAYYLHYTLVlv-vfSGVLVIGIYHLLIARfki 121 thale cress
O74926    50 LLQKRQLYEIITYVTLHLSMLHIVFNFVSLLPAMSQFEKKQ-----GTLACILVTVIpytlfPGIMHLIVYHFFLRKdy- 123 Schizosaccharomyces...
EHH17235  54 ALRNWQVYRLVTYIFVYENPISLLCGAIIIWRFAGNFERTV-----GTVRHCFFTVI-----FAIFSAIIFLSFEAVssl 123
Q8LB17    58 IISRFQVYRFYTAIIFHGSLLHVLFNMMALVPMGSELERIM-----GSVRLLYLTVL-----LATTNAVLHLLIASLagy 127 thale cress
Q9RSX7    86 PRQVGTFWHVFTAPFLHAGFPHLIANTVPLAVLAFMTAVR------SVSRFLVATFL-----IALIGGGLVWLLGRSg-- 152 Deinococcus radiodu...
P9WM21    71 PLKTDGLWGVIFAPLLHANWHHLMANTIPLLVLGFLMTLA------GLSRFVWATAI-----IWILGGLGTWLIGNVgss 139 Mycobacterium tuber...
P53426    83 LLKTDVLWGISFAPVLHANWQHLVANTIPLLVLGFLIALA------GLSRFIWVTAM-----VWIFGGSATWLIGNMgss 151 Mycobacterium lepra...
P74553    49 PRSLEGLRGIVFAPFLHADFGHLIANSVPFVVLAWLVMLQ------EVSDFWIVTII-----TMVVGGLGVWLIAPPn-- 115 Synechocystis sp. P...
2NRF_A   106 ------------WFGGLSGVVYALMGYVWLRGERDPQSGIYLQRG------LIIFALIWIVAGWFDLFgm--sMANGAHI 165 Escherichia coli
Q12270   117 ----------eaLVAGASGWCFTLFAYYSFKESQIRPRTRIFRTDysiptlYTPLVLLVAIAVVIPGS------SFWGHF 180 Saccharomyces cerev...
Q9M1B5   122 dy------frrvTAVGYSCVVFGWMTILSVKQPSSKLNLFGLLSLpi---sFAPFESLIFTSIIVPQA------SFLGHL 186 thale cress
O74926   124 -----------vSIAGLSGWAFAFISASCVHSPQRLISFFNLFSIpa---yCFPIIYLIMTTILVPKA------SFIGHA 183 Schizosaccharomyces...
EHH17235 124 sk-----lgeveDARGFTPVAFAMLGVTTVRSRMRRALVFGMVVPs----vLVPWLLLGASWLIp-------qTSFLSNV 187
Q8LB17   128 npfyqydhlmneCAIGFSGILFSMIVIETSLSGVTSRSVFGLFNVpa---kLYPWILLIVFQLLMTn------VSLLGHL 198 thale cress
Q9RSX7   153 -----------sVHLGASELVFGYLAYLLGVGWWERTPLSVVIAV------IAFALYGGVLWGVLPSNp---aISWEAHL 212 Deinococcus radiodu...
P9WM21   140 c--------gptDHIGASGLIFGWLAFLLVFGLFVRKGWDIVIGL------VVLFVYGGILLGAMPVLgqcggVSWQGHL 205 Mycobacterium tuber...
P53426   152 f--------gptDHIGVSGLIFGWLAFLLVFGLFVRRGWDIIGCM-------VLFAYGGVLLGVMPVLgrcggVSWQGHL 216 Mycobacterium lepra...
P74553   116 -----------tVTVGASILIFGYLGFLLFRGWFQKNLASIVLSI------VVLVLYGSALWGLLPGRa---gVSWQGHL 175 Synechocystis sp. P...
2NRF_A   166 AGLAVGLAMAFVDSLNA 182 Escherichia coli
Q12270   181 FGLCVGYAIGYKESWFN 197 Saccharomyces cerevisiae S288C
Q9M1B5   187 SGILVGYAISWGLIGGM 203 thale cress
O74926   184 SGAVMGYCTPFMLGSIP 200 Schizosaccharomyces pombe 972h-
EHH17235 188 CGLSIGLAYgltycysi 204
Q8LB17   199 CGILSGFSYSYGLFNFL 215 thale cress
Q9RSX7   213 FGFIGGLVAAALLHRKV 229 Deinococcus radiodurans
P9WM21   206 SGAVAGVVAAYLLSAPE 222 Mycobacterium tuberculosis H37Rv
P53426   217 CGAISGVVAAYLLSAPE 233 Mycobacterium leprae TN
P74553   176 FGFIGGAIAAWLIAREK 192 Synechocystis sp. PCC 6803
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