Conserved Protein Domain Family
RING-HC_TRIM60-like_C-IV
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cd16607: RING-HC_TRIM60-like_C-IV 
RING finger, HC subclass, found in tripartite motif-containing proteins TRIM60, TRIM61, TRIM75 and similar proteins
TRIM60, also known as RING finger protein 129 (RNF129) or RING finger protein 33 (RNF33), is a cytoplasmic protein expressed in the testis. It may play an important role in the spermatogenesis process, the development of the preimplantation embryo, and in testicular functions. RNF33 interacts with the cytoplasmic kinesin motor proteins KIF3A and KIF3B suggesting possible contribution to cargo movement along the microtubule in the expressed sites. It is also involved in spermatogenesis in Sertoli cells under the regulation of nuclear factor-kappaB (NF-kappaB). TRIM75 mainly localizes within spindles, suggesting it may function in spindle organization and thereby affect meiosis. Both TRIM60 and TRIM75 belong the C-IV subclass of the TRIM (tripartite motif) family of proteins that are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, a B2-box, and two coiled coil domains, as well as a PRY domain and a B30.2/SPRY (SplA and ryanodine receptor) domain positioned C-terminal to the RBCC domain. In contrast, TRIM61 belongs to the C-V subclass of the TRIM family that contains RBCC domains only. Its biological function remains unclear.
Links
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Statistics
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PSSM-Id: 438269
Aligned: 10 rows
Threshold Bit Score: 89.7892
Created: 21-Apr-2016
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #  #           # #  #  #             #  #    
Q5EBN2        13 EASCPICLDYLKDPVTISCGHNFCLSCIIMswkdlhdsFPCPFCHFCC 60  human
Q495X7        13 ESSCPICLEYLKDPVTINCGHNFCRSCLSVswkdlddtFPCPVCRFCF 60  human
XP_011823155  13 EASCPICLDYLKDPVTISCGHNFCLSCIIMswkdlddsFPCPFCHFCC 60  drill
XP_004606286  13 EIICPICLEYFNNPLTINCGHNFCASCIKFswlyqretFPCPVCRYPH 60  European shrew
VCX42053      13 GASCPICLDYLKEPVTINCGHNFCLSCISMfwkdlngtFPCPFCRYCS 60  wolverine
VFV29113      13 ESNCPICLDYLKDPVTINCGHNFCRSCINMmwkdledtFPCPVCRFCF 60  Spanish lynx
XP_003803177  24 EASCPICLDYLTDPVTICCGHNFCHSCISMswkdlegsFPCPSCRFCC 71  small-eared galago
A6NK02        13 EAKCSICLDYLSDPVTIECGHNFCRSCIQQswldlqelFPCPVCRHQC 60  human
XP_006727295  13 EANCPICLDYLRDPVTTECGHNFCRCCIQQswadrkdrFPCPVCRHTY 60  Weddell seal
XP_005860609  13 EASCPICLDYLRDPVTTECGHNFCSSCIHQrweglqdtFPCPVCLHHC 60  Brandt's bat

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