Conserved Protein Domain Family
RRM_PRC

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cd12624: RRM_PRC 
RNA recognition motif (RRM) found in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
This subgroup corresponds to the RRM of PRC, also termed PGC-1-related coactivator, one of the members of PGC-1 transcriptional coactivators family, including peroxisome proliferator-activated receptor gamma coactivators PGC-1alpha and PGC-1beta. Unlike PGC-1alpha and PGC-1beta, PRC is ubiquitous and more abundantly expressed in proliferating cells than in growth-arrested cells. PRC has been implicated in the regulation of several metabolic pathways, mitochondrial biogenesis, and cell growth. It functions as a growth-regulated transcriptional cofactor activating many nuclear genes specifying mitochondrial respiratory function. PRC directly interacts with nuclear transcriptional factors implicated in respiratory chain expression including nuclear respiratory factors 1 and 2 (NRF-1 and NRF-2), CREB (cAMP-response element-binding protein), and estrogen-related receptor alpha (ERRalpha). It interacts indirectly with the NRF-2beta subunit through host cell factor (HCF), a cellular protein involved in herpes simplex virus (HSV) infection and cell cycle regulation. Furthermore, like PGC-1alpha and PGC-1beta, PRC can transactivate a number of NRF-dependent nuclear genes required for mitochondrial respiratory function, including those encoding cytochrome c, 5-aminolevulinate synthase, Tfam, and TFB1M, and TFB2M. Further research indicates that PRC may also act as a sensor of metabolic stress that orchestrates a redox-sensitive program of inflammatory gene expression. PRC is a multi-domain protein containing an N-terminal activation domain, an LXXLL coactivator signature, a central proline-rich region, a tetrapeptide motif (DHDY) responsible for HCF binding, a C-terminal arginine/serine-rich (SR) domain, and an RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain).
Statistics
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PSSM-Id: 410035
Aligned: 6 rows
Threshold Bit Score: 186.559
Created: 16-Feb-2012
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5VV67       1541 ERRVVFIGKIPgrMTRSELKQRFSVFGEIEECTIHFRvqGDNYGFVTYRYAeEAFAAIESGHKLRqADEQPFDLCFGGRR 1620 human
XP_002940617 1505 ERRVVYIGKINsrMTRSELKSRFSAFGEIEECTIHFReeGDNYGFVTYRYTcEAFAAIENGHKLRlPDELPFDLCFGGRR 1584 western clawe...
XP_421717    1481 ERRVVFIGKIPsrMTRSELRHRFSVFGDIEECTLHFRseGDNYGFVTYRYAeEAFAAIESGHKLRrPDEQPFDLCFGGRR 1560 chicken
XP_003199581  445 ERRVVYVGGIResMAPSDLKDRFSLFGKVEDCTVHLRshGDNYGFVTYYNTdDAYAAIENGGKLRrPDELPFDICFGGRR 524  zebrafish
XP_014352804 1646 ERRVVYIGKIHggMTRAELKERFSYFGEIEECTIHFReqGDNYGFVTYRYTtDAFAAIENGHKLRrPDELPFDLCFGGRR 1725 coelacanth
XP_007908758 1406 ERRVVYIGKIRngMMREELKRRFEVFGEIEDCNIYFReeGDNYGFVTYRYTcDAFAAIENGQTVRrPDELPFDLCFGGRR 1485 elephant shark
Q5VV67       1621 QFCKRSYSDLD 1631 human
XP_002940617 1585 QFCKSSYADLD 1595 western clawed frog
XP_421717    1561 QFCRRNYADLD 1571 chicken
XP_003199581  525 QFCKSNYADLD 535  zebrafish
XP_014352804 1726 QFCKTTYADLD 1736 coelacanth
XP_007908758 1486 QFCKTSYADLD 1496 elephant shark
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