2L2L


Conserved Protein Domain Family
P66_CC
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pfam16563: P66_CC (this model, PSSM-Id:406867 is obsolete and has been replaced by 465178)
Coiled-coil and interaction region of P66A and P66B with MBD2
This family is a short coiled-coil interaction region on the transcriptional repressors P66A and P66B. The P66A and B, or alpha and beta, complex with MBDs or methyl-binding domain-containing proteins via a coiled-coil region on each. This P66-MBD2 complex forms part of an assembly with NuRD, nucleosome remodelling and deacetylation protein. MBD2-NuRD binds methylated DNA and regulates transcription of eg, the foetal beta-globin gene during development.
Links
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Statistics
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PSSM-Id: 406867
Aligned: 15 rows
Threshold Bit Score: 38.5019
Created: 27-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2L2L_A          2 SPEERERMIKQLKEELRLEEAKLVLLKKLRQSQI------QKE 38   human
EDX09986      183 ELKEREKSLRKLRQDLRNEETKLMLLKKLKQSQQv-----MKE 220  Drosophila simulans
ETN61652      165 EIWERERGLRKLREELRSEETKLVLLKKLKQSQQv----mMKE 203  Anopheles darlingi
EFA06839      107 ELKQRDRGLRRLREDLRAEEMKLVLLKKLKQSQQ------LKE 143  red flour beetle
XP_002423105  198 DLNEKEKLLRKLREDLRNEEMKLVLLKKLRQSQ-------MKE 233  human body louse
EKC41807      157 EIRKRRKVVKRLQAELRNEEAKLILLRKMRQSQV------SSP 193  Pacific oyster
XP_784127     388 QHEARSIIMKKLQEELRNEETKLLLLKKLRLNQQ------QPV 424  purple sea urchin
EFO19194      187 QKKEREMMVKALEAELRREEAKLSMLRKLRISQQhsvkqiQEA 229  eye worm
XP_007237798  170 SVAERQRVIKALREELRLEEARLVLLKKLRQSQL------QKE 206  Mexican tetra
NP_001038440  164 TGEERQQMIKALREELRLEEAKLVLLKKLRQSQM------QKE 200  zebrafish
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