2L2L


Conserved Protein Domain Family
P66_CC
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pfam16563: P66_CC 
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Coiled-coil and interaction region of P66A and P66B with MBD2
This family is a short coiled-coil interaction region on the transcriptional repressors P66A and P66B. The P66A and B, or alpha and beta, complex with MBDs or methyl-binding domain-containing proteins via a coiled-coil region on each. This P66-MBD2 complex forms part of an assembly with NuRD, nucleosome remodelling and deacetylation protein. MBD2-NuRD binds methylated DNA and regulates transcription of eg, the foetal beta-globin gene during development.
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Statistics
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PSSM-Id: 465178
Aligned: 14 rows
Threshold Bit Score: 42.7922
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2L2L_A          2 SPEERERMIKQLKEELRLEEAKLVLLKKLRQSQI------QKEATA 41  
EKC41807      157 EIRKRRKVVKRLQAELRNEEAKLILLRKMRQSQV------SSPSIP 196 
EDX09986      183 ELKEREKSLRKLRQDLRNEETKLMLLKKLKQSQQv-----MKENLV 223 
EFA06839      107 ELKQRDRGLRRLREDLRAEEMKLVLLKKLKQSQQ------LKENVA 146 
XP_002423105  198 DLNEKEKLLRKLREDLRNEEMKLVLLKKLRQSQ-------MKENIA 236 
XP_012552065  141 EIWERDRRLRALREKLRAEETRLVLLRKIRQSQQatglppAKESga 186 
ETN61652      165 EIWERERGLRKLREELRSEETKLVLLKKLKQSQQv----mMKENLI 206 
XP_019466607   63 SIEERQQLIKQLRDELRLEEARLVLLKKLRQSQL------QKENVV 102 
NP_001038440  164 TGEERQQMIKALREELRLEEAKLVLLKKLRQSQM------QKENVV 203 
XP_007237798  170 SVAERQRVIKALREELRLEEARLVLLKKLRQSQL------QKENLS 209
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