3NO8,3GBW,3HWJ


Conserved Protein Domain Family
PHR
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pfam08005: PHR 
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PHR domain
This domain is called PHR as it was original found in the proteins PAM, highwire and RPM. This domain can be duplicated in the highwire, PFAM and PRM sequence. The C-terminal region of the protein BTBD1 includes the PHR domain and is known to interact with Topoisomerase I, an enzyme which relaxes DNA supercoils.
Links
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Statistics
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PSSM-Id: 462339
Aligned: 62 rows
Threshold Bit Score: 91.145
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3NO8_A         18 NRFQQVESRWGYSGTs-DRIRFSVNKRIFVVGFGLYGSIHGPTDYQVNIQI-----IHTD----SNTVLGQNDTGFSCDG 87  
EKC41654     1913 NRFESHGGGWGYSGHsiEAVRFMSDTDILLGGFGLFGGRGE---YYGRIKLfd-lgPDGGdnegDGELIGETDEVAFECG 1988
XP_018949695   13 NRFESHGGGWGYSAHsvEAIRFCADADILLGGLGLFGGRGE---YTAKIKLfe-lgPDGGdhetDGALLAETDVLAYDCA 88  
EFN81005     1178 SRFESHGGGWGYSPHsiEAIRFMPDTDILLGGYGLFGGRGE---YTAKIKLfd-igIDGGdqenDGELLAETEEIPYECG 1253
XP_002430461 1647 NRFESHGGGWGYSGHsvEAIRFMADADIILGGFGLFGGRGE---YTAKIKLld-igVDGGeqesDGEVIAETDDIPYECG 1722
EFX74318     1227 NRFESHGGGWGYSGHsvEAIRFMSDTDILLGGFSLFGGRGE---YMGKIKVfd-lgIGGGdqegDGELLAETDEVVYECG 1302
CDP93813     1140 NRFDGYGGGWGYSAHsvEAIQFRTSRDIRFFGVGLYGGRGE---YIAKLKLyrlcpPDYne--qNVELLSESDEMLYECA 1214
Q17551       1056 NRFDGTGGGWGYSANsvEAIQFKVSKEIRLVGVGLYGGRGE---YISKLKLyrqigTEAde--lYVEQITETDETVYDCG 1130 Caenorhabditi...
XP_004998670 1312 SRYSSQGGGWGYGGSspDAIGFKVNQPIAICGFGLYGQDSMs--FNATMKL--------FvdgkAEEPLATKTTTYSSNC 1381
3GBW_A          9 NRFESHGGGWGYSAHsvEAIRFSADTDILLGGLG---LFGGRGEYTAKIKLfe-lgPDGGdhetDGDLLAETDVLAYDCA 84  

3NO8_A         88 SAS-TFRVMFKEPVEVLPNVNYTACATLKGPD-SHYGTKGMRKVTHESpttgaKTcFTFCYAAGNNNGTSVEDGQIPEVI 165 
EKC41654     1989 ARE-KYAMLFDEPIPIHANSWYVAWARISGPS-SDCGSTGQSVVTTDD-----QViFKFKSSKKSNNGTDVNAGQIPQLL 2061
XP_018949695   89 ARE-KYAMMFDEPVLLQLGWWYVAWARVSGPS-SDCGSHGQATITTDD-----GVvFQFKSSKKSNNGTDVNAGQIPQLL 161 
EFN81005     1254 PRQ-KYSILFDEPVALQANRWYVAWVKVSGPS-SDCGSGGQGMVTAED-----QVmFYFKSSKRSNNGTDVNAGQIPQLL 1326
XP_002430461 1723 PRQ-KYPMLFEEPLLLQGNRWYIAWARISGPS-SDCGSNGQAVIVTED-----QIsFYFKSSKKSNNGTDVNAGQIPQLL 1795
EFX74318     1303 ARQ-RFPILFSQPLRLQANRWYLAWARVNGPS-SDCGSGGQSTVTTED-----QVtFTFKPSKKSNNGTDVNAGQLPQIL 1375
CDP93813     1215 AHE-KAQLLFSRCVLIKSNLWHVICAQINGPS-SDCGSNGQSNVIGDD-----GVqFFFRNSRMSNNGTDVNVGQIPEFL 1287
Q17551       1131 AHE-TATLLFSQPIVIQPNHWHVVSAKISGPS-SDCGANGKRHVEC-D-----GVtFQFRKSAVSNNGTDVDVGQIPELY 1202 Caenorhabditi...
XP_004998670 1382 PGRnYAAILFDEPVTVEPHQLYIAWALIQSPHsSICGSSGQSVVEE-D-----GVqFNFVSTHHGSNGTDVSSGQVPAIL 1455
3GBW_A         85 ARE-KYAXXFDEPVLLQAGWWYVAWARVSGPS-SDCGSHGQASITTDD-----GViFQFKSSKKSNNGTDVNAGQIPQLL 157 

3NO8_A        166 FY 167 
EKC41654     2062 YR 2063
XP_018949695  162 YR 163 
EFN81005     1327 YR 1328
XP_002430461 1796 YK 1797
EFX74318     1376 FR 1377
CDP93813     1288 YV 1289
Q17551       1203 YQ 1204 Caenorhabditis elegans
XP_004998670 1456 FC 1457
3GBW_A        158 YR 159
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