pfam18372: I-EGF_1 (this model, PSSM-Id:375798 is obsolete and has been replaced by 465729)
Integrin beta epidermal growth factor like domain 1
This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.
Jiyao W et al.(2023). "The conserved domain database in 2023.",