3T3M,4UM9,7NWL


Conserved Protein Domain Family
I-EGF_1

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pfam18372: I-EGF_1 
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Integrin beta epidermal growth factor like domain 1
This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.
Statistics
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PSSM-Id: 465729
Aligned: 117 rows
Threshold Bit Score: 30.921
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3T3M_B        437 CQAQAEPNSHRCNnGNGTFE-----------CGVC-----------RCG-PGW 466  human
KPP66336      407 CEKNPEKNAKWCS-NNGDLI-----------CGMC-----------KCY-AGW 435 
XP_005448019  458 CEKSPIRNAPRCN-GKGDLV-----------CGKC-----------RCH-SGW 486 
CAG02568      417 CEKIRVENAPRCH-GNGRLV-----------CGKC-----------ECY-SGW 445 
6_pfamImport    1 CEKSAIPAAAKCH-GHGDLV-----------CGRC-----------QCY-DGW 29  
XP_023804990  458 CEMTPILKSDRCH-RNGDLV-----------CGKC-----------QCH-SGW 486 
XP_015212019  457 CEETPIKKAVRCN-RNGDLV-----------CGVC-----------TCN-PGW 485 
XP_012548363  176 CSAQPEPNSETCH-KNGQLI-----------CGIC-----------ECY-DGW 204 
XP_011409489  234 CESQPTRGSTECS--NGNLT-----------CGLC-----------NCD-EGW 261 
XP_023196223  457 CEKTPTLKASRCH-GNGKLVcgkclcddgwaGAFCncsknsglskdQCIgPGV 508  southern platyfish
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