2L2L


Conserved Protein Domain Family
P66_CC
?
pfam16563: P66_CC (this model, PSSM-Id:374633 is obsolete and has been replaced by 465178)
Click on image for an interactive view with Cn3D
Coiled-coil and interaction region of P66A and P66B with MBD2
This family is a short coiled-coil interaction region on the transcriptional repressors P66A and P66B. The P66A and B, or alpha and beta, complex with MBDs or methyl-binding domain-containing proteins via a coiled-coil region on each. This P66-MBD2 complex forms part of an assembly with NuRD, nucleosome remodelling and deacetylation protein. MBD2-NuRD binds methylated DNA and regulates transcription of eg, the foetal beta-globin gene during development.
Links
?
Statistics
?
PSSM-Id: 374633
Aligned: 16 rows
Threshold Bit Score: 37.3436
Created: 25-Apr-2019
Updated: 18-Jul-2019
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
2L2L_A          2 SPEERERMIKQLKEELRLEEAKLVLLKKLRQSQI------QKE 38   human
EFA06839      107 ELKQRDRGLRRLREDLRAEEMKLVLLKKLKQSQQ------LKE 143  red flour beetle
EEB10367      198 DLNEKEKLLRKLREDLRNEEMKLVLLKKLRQSQ-------MKE 233  human body louse
ETN61652      165 EIWERERGLRKLREELRSEETKLVLLKKLKQSQQv----mMKE 203  Anopheles darlingi
EKC41807      157 EIRKRRKVVKRLQAELRNEEAKLILLRKMRQSQV------SSP 193  Pacific oyster
XP_784127     388 QHEARSIIMKKLQEELRNEETKLLLLKKLRLNQQ------QPV 424  purple sea urchin
EFO19194      187 QKKEREMMVKALEAELRREEAKLSMLRKLRISQQhsvkqiQEA 229  eye worm
PDM66359      234 QKEERTRMIKQAEADLRNEEAKLTMLKKMRASQI------PKH 270  Pristionchus pacificus
NP_001038440  164 TGEERQQMIKALREELRLEEAKLVLLKKLRQSQM------QKE 200  zebrafish
XP_012552065  141 EIWERDRRLRALREKLRAEETRLVLLRKIRQSQQatglppAKE 183  domestic silkworm
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap