4DLQ


Conserved Protein Domain Family
GAIN
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pfam16489: GAIN (this model, PSSM-Id:374574 is obsolete and has been replaced by 465137)
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GPCR-Autoproteolysis INducing (GAIN) domain
The GAIN a domain of alpha-helices and beta-strands that is found in cell-adhesion GPCRs and precedes the GPS motif where the autoproteolysis occurs, family, pfam01825. The full GAIN domain, comprises the GPS and the GAIN, in cell-adhesion GPCRs, and is the functional unit for autoproteolysis. The GPS motif at the end of the GAIN domain is an ancient domain that exists in primitive ancestor organisms, and the full GAIN + GPS is conserved in all cell-adhesion GPCRs and all PKD1-related proteins.
Links
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Statistics
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PSSM-Id: 374574
Aligned: 110 rows
Threshold Bit Score: 105.798
Created: 25-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4DLQ_A        93 NAANIASELARHTRGSIYAGDVSSSVKLMEQLLDILDAQLQalrpieresagknynkmhkrertckDYIKAVVETVDNLL 172 Norway rat
EHB01762     138 EPVTLLQKIYRNSMTDISLMDIITYIEILAKSSPLLGYMNNtvsdk---------------dtfsnSTLTEFVKTMNNFI 202 naked mole-rat
Q923X1       187 EQTTLLQEIYRNSEAELSLMDIVTYIEILTESSSLLGHPNSttsyk---------------dahfnSTLTEFGETINNFV 251 house mouse
Q9ESC1       186 EQLTLLHEIYKNSEAELSLVDIVTYIEILTESSSLQGYIKNttspk---------------dayfgSALTEFGKTVNNFV 250 Norway rat
XP_023365550 186 EPVALLQEVYRSSAtDLSPMDIITYIEILAELSPLLGYMNNtvstk---------------dtppnTTLTEFVKTMNNFI 250 small-eared galago
XP_015211231 170 EPQSLLEEIRKQTSGDLSPVDMISYVEVLSRSVPSLSVMNDtvidk---------------ealtnATIKDFVNTVNNLV 234 spotted gar
XP_001362859 190 ELRNLLQEIYQNSEQVLFPIDVLTNVEALSASSSSLSYMNSnvsek---------------eafinTTINVFVNTINNLV 254 gray short-tail...
XP_023357504 190 EPLNLLQEIYQNSEQALFPIDILTNVEALSTFSPSLCFMSSnvsek---------------eaftnTTINVFVNTVNNLV 254 Tasmanian devil
XP_003411266 138 EPVALLQEVYRNSVTDLSPVDIITYIEVLAESSPFLGYMNStntak---------------dtlsnSILTELVKTMNNLV 202 African savanna...
XP_007665758 149 EPVTLLQEIYKGSAEELSPVDIITYIEVLALSSPLLSVMNNtisdk---------------elvtnTTINVFVNVANNLV 213 platypus

4DLQ_A       173 RPEALESWKDMNATEQvHTAtmLLDVLEEGAFLLADNVREPARFLAAKQNVVLEVTVLSTEGQVqEL--VFPQeyasESS 250 Norway rat
EHB01762     203 QKDTFKIWDKLSSNHRrAHLtkLMHTAEQATLRISQNFQKTTQFDTNSTDIALKVFFFDSYHMKhTh-pHMNVd---GDY 278 naked mole-rat
Q923X1       252 ERSTHKMWDQLPTNHRrLHLtkLMHTAELVTLQIAQNTQKNSQFDMNSTDLALKVFAFDSTHMKhAh-pHMNVd---GGY 327 house mouse
Q9ESC1       251 EKNTHEMWDQLPTNRRrLHLtkLMHAAEHVTLQISQNIQKNTQFDMNSTDLALKVFVFDSVHMKhTh-pHMNVd---GGY 326 Norway rat
XP_023365550 251 QKDTFMIWDKLPTHRRqTHLtkLMHTAEQATLRITQSFQKTTQFDANSSDVALKVFFLDPNHMThIh-pHMKVd---GDY 326 small-eared galago
XP_015211231 235 ERDELVAWNRINTEDRkKTVtkLLHTVEEATLNISQNFKKATEMEVNASDIALKLYIFDTQQIKsNVsaNVNIe---GDF 311 spotted gar
XP_001362859 255 QKDKITVWDKLSADNRrTSLtkLMHTAEQTMLSMSQNFKKTTQLEINSSDMGLKLFAFDSHHMKhIh-pHMNMe---GNH 330 gray short-tail...
XP_023357504 255 QKDKITIWDKLSADNRrTSLtkLMHTAEQTMLNMSQNFKKTTQLEINSSDMGLKLLAFDSHHMKhIh-pHVNMe---GNY 330 Tasmanian devil
XP_003411266 203 QTDTFTVWNKLSTNNRrTHLtkLMHTAEQVTLSISQNLQKTTQLDTNSSDVALKIFFFDSHQMQhMh-pQMNVd---GDY 278 African savanna...
XP_007665758 214 QKDKITIWNKLSTDNRrKSLtkLMHTVEQAILNVSQNFKKTTQIEVNSSDMALKVFAFDSHHIKhIh-hHVSMe---GDY 289 platypus

4DLQ_A       251 IQLSANTIKQ-NsrngvVKVVFIL----YNNLGLFLStenatvklA----GEAGTGGPGGASL-VVNSQVIAASINK 317 Norway rat
EHB01762     279 IKVFPKRKAAyNle-gnVAVAFLY----YKSIGSLLSssd---nfS----LEPQFSDNSEEQE-RVISSVISVSINS 342 naked mole-rat
Q923X1       328 VKISPRRKAAhGtt-gnVVVAFLC----YKSIGPLLSssd---nfL----LDTQN-DNSEGKE-KVISSVISASISS 390 house mouse
Q9ESC1       327 VKISPRRKSAyDpn-gnVIVAFLC----YRSIGPLLSssd---dfL----LGAQS-DNSKGKE-KVISSVISASISS 389 Norway rat
XP_023365550 327 INIFPKKRASfDsd-gnVAVAFLY----YKSMGPLLSs-------SntifLEPQNYDNSEEEEkvissvisvsissn 391 small-eared galago
XP_015211231 312 IALTQKYDKDiDtn-gsVSIVFLR----YNSIRVLLEtn----nvL----VETDNSQAIETSDfTVNSQVVAAAIKA 375 spotted gar
XP_001362859 331 IKIYPKRKDEyDsn-grKT----WcfcdYKSIGALLLspe---saS----QETESHESPEQEE-IVISSVVSVSISA 394 gray short-tailed ...
XP_023357504 331 IKIYPKKKDEnYsn-gtVVVVFLH----YKSIGAMLSssl---saS----QETESNNNPEQEE-IVISSIVSVSVSA 394 Tasmanian devil
XP_003411266 279 IKILPKGKPAyNsd-gnVAVAFLY----YKSIGPLLSss----dnL----LEPQNSDHSEEEE-RVISPVISVSISS 341 African savanna el...
XP_007665758 290 IKIYSRKKDVhDsn-gtVAVVFLR----YDSIGSLLSsse---nsF----LEIQNSDSSEQQE-IVISSIIAVTISS 353 platypus
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