Conserved Protein Domain Family
PKK
?
pfam12474: PKK (this model, PSSM-Id:372134 is obsolete and has been replaced by 463600)
Polo kinase kinase
This domain family is found in eukaryotes, and is approximately 140 amino acids in length. The family is found in association with pfam00069. Polo-like kinase 1 (Plx1) is essential during mitosis for the activation of Cdc25C, for spindle assembly, and for cyclin B degradation. This family is Polo kinase kinase (PKK) which phosphorylates Polo kinase and Polo-like kinase to activate them. PKK is a serine/threonine kinase.
Links
?
Statistics
?
PSSM-Id: 372134
Aligned: 74 rows
Threshold Bit Score: 77.9592
Created: 1-May-2019
Updated: 18-Jul-2019
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
EDO48741      575 QWETQEQRFEQELLELERKYEIELDNLSRNQKRDIEKLELTQNADLRTSSRKMRQDQEKELKKFKENLKEEQKRSKKEV- 653  starlet sea a...
CBY20137      893 AKSQLKDQFLLQKMLLMARHDKEMEQMIEHNDRLIKSLQERQRLEKLKLPKWQRNDARTRENMFKQSIRIQNPAILDKEi 972  Oikopleura di...
EEN47597      897 TKQHQKDQFFLQRQQLLKRHEKEIEQVNRINNREQDELVRRHTSEKRRLPKIQRSEGKVREQMFKKSLRISSM-STPQQd 975  Florida lancelet
XP_003383893  691 qkqqVREAFHMQRHQMQMRHQKEYDQQLRRDNFRLDELKQTQLFEKKQLPKQLNAEFKVQL----NELRKTMGLRRTAEd 766  Amphimedon qu...
XP_011679132  843 KKNQLKDMFFLQRHHLvlgqekEVQQLKNYFDREEEELNQKHVLDQRQLPRRLRNEKQARLSMFKKSLQIHKPGYTAEQe 922  purple sea ur...
XP_005155384 1089 FKQQVKEQYSLQRQQLTKRHNKDKERASRFQQSLLEEQKSLQAQERASFLKTQKAEAKSRLNQLKMELRKQG--LSGPEq 1166 zebrafish
XP_022536437 1208 FKQQVKEQYSLQRQQLSKRHNKDMERASRFQQSLVEEQKSAQAQERGRLLKAQRAESKTRLTQYRQELRKQG--LTGPEq 1285 Mexican tetra
XP_015197419 1113 FKQQVKEQFSLQRQQLIKRHSKDKERAMRFHQSLLEEQRSLFAQERARLPRTQRPEAKNRLAQFKLRLKSQG--LNSQEm 1190 spotted gar
XP_017948158 1117 FRQHITEQHSLQRQQLRKRHEKDMERLKHYQSLLVDDMKSKHTQERSQWQKAQRTEARARQAMFKERVKSQG--LSASEq 1194 tropical claw...
XP_005996976 1405 FKQQVKEQFSLQRQQLLKRHEKETERMNRFHQFLLEDLKGKQAQEKGRLPKFQRNDAKTRLAMFKESLKIQA--ISAPEq 1482 coelacanth

EDO48741      654 -DKLPRNQRKDAWKKKKEELDLSHQQ-A-EHEFQAMQQVEFEKFYKQMIDLHRQKMFEME 710  starlet sea anemone
CBY20137      973 nEKLKDFKYSEDKRQRNEKTRQEDKH-ErQLKELHTKCENYISEMKQIQSEKKRLLVETE 1031 Oikopleura dioica
EEN47597      976 kEKLKQFQTQETKRMKAEQQRQEQKH-TkQLEELRSRHDVTMQELQQMQNEKRHMLIEHE 1034 Florida lancelet
XP_003383893  767 kAKLKKLEQRYIIKEESERSLMKEKHtR-DLETQKAEMENNIREMVEIQNEKKLTLTQQE 825  Amphimedon queenslandica
XP_011679132  923 rEKIKEFQDNETARFKAEIAHQKAKQ-EkKLHNERQNSEAIMQELLSDHNEKRKVLMEQE 981  purple sea urchin
XP_005155384 1167 rQHLTQLLSEEEARQKQEKQSLQESH-EsQLKAVQEQCDASTAELQQLQNEKLQVLVDME 1225 zebrafish
XP_022536437 1286 rHKITQFLAEEESRQKQERSQLQETQ-EsQLKEVQEQCDANITELQQLQNEKLQVLVEME 1344 Mexican tetra
XP_015197419 1191 rQRLTQFLAEEESRQKEERLSLQQSQ-ErQLRELQEQCDSNIAELQHIQNEKLHVLVEWE 1249 spotted gar
XP_017948158 1195 kERSKQFLLQETAYQKSETQRQQQRQ-EeEMKKLQQHLEETCNELQQIQEEKIQTL-QAQ 1252 tropical clawed frog
XP_005996976 1483 rEQIKQFHQQEEARQKAEIQQQQQKH-EaQLTELQEQLNSNISELQQLQNEKLHLLVDRE 1541 coelacanth
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap